Science Class Towers

These champions have the highest chance to clear a fight in towers with a disadvantage of 40 challenge rating. 

Silk - (sp3 rotation) build to three bars of power and use MLLLH knockdown throwing sp3 before the fury expires. After sp3 animation quickly dash for a MM and MLM followed by a full combo starting with a light attack and ending with a heavy (example LLMLH) throwing hulk relic after first hit of heavy attack. While opponent is stunned from relic quickly throw one light attack, dash backwards and quickly forwards into a MLLLH and launch sp2 after the first hit of the heavy attack. If done correctly silk will have three fury passives during the sp2 and wil have a massive burst to end. 
(Sp2 rotation) build combo until at sp1 then chain a heavy attack mid combo and throw sp1 after first hit of heavy. Build to sp2 and when slightly above a bar of power use a combo with heavy after four hits, use relic after first hit of heavy, chain another combo into heavy into sp2 for double fury passives and bursts. This can be done twice for a rhythm of sp1 sp2 sp1 sp2. This rotation is not nearly as potent as the sp3 rotation.
Hulk battlecast relic preferred. Offensive stat focus critical rating or special damage.

Spider woman (Jessica Drew) - While building between two and three bars of power, punish the defenders heavy and special attacks to gain fury buffs faster. Intercepting the defender will do the same. Throw sp2 followed by sp1 as frequently as possible up to 4 total. If possible hold block and bait opponents heavy attacks to avoid triggering power stings before they are all stacked. Any man battlecast relic preferred. Offensive stat focus critical rating or special damage.

Spider Ham - Parry and use MM or MLM combos to stack porker popper debuffs on the opponent. If the opponent is not throwing special attacks, use your heavy attack to knockdown or sp1 to knockdown and place a taunt debuff making them more likely to do throw specials. If the opponent is throwing specials somewhat frequently, build to sp2 and launch. RNG plays a role in deciding how many porker poppers are consumed and how many are reapplied when the opponent uses a special attacks. Ant man battlecast relic preferred. Offensive stat focus critical rating.

Red Guardian - Bait a heavy attack and take the first hit into block. This will stun the opponent and apply a trauma debuff. Through the fight use heavy attacks before the trauma expires to refresh it. Throw sp2 three times preferably as the shield durably returns each time. Hulk battlecast relic preferred. Offensive stat focus critical rating or special damage. 

These champions are some of the most solid in their class for towers. A 35 challenge rating disadvantage is nothing to them

Scorpion -

Hulk - 

Photon - 

Human Torch -  Use Flame On prefight. Best when used against a mystic opponent or one that deals energy damage. Use MLM combos and build to sp2 and use three times. Bait opponents special attacks frequently for the additional power sting damage. Ant man battlecast relic preferred. Offensive stat focus critical rating or special damage.

These champions are hard hitters but need optimized gameplay, rotations, or masteries for a good win at 35 challenge rating disadvantage

Lizard - 

Spot - 

Luke cage - Use heavy attacks to apply debilitate making debuffs last longer. Use light ending combos to apply more exhaustions. Order of specials is sp3 (use heavy right before, then sp2 followed by sp1. Hulk battlecast relic preferred. Offensive stat focus critical rating or special damage.

These champions have either unorthodox playstyle or specific requirements to win at a 35 challenge rating disadvantage such as relics, crit RNG, or opponent AI

Abomination (Immortal) - 

Morbius -

Hulk (Immortal) - 

Joe Fixit -

Titania - 

These champions are the problem children and need a relatively smaller health pool opponent to have a chance at winning a 35 challenge rating disadvantage fight

Spider man - 

Spider punk - At the start of the fight dash back, if you use parry at the start it will trigger evade. Evade will not inflict physical vulnerability unless the opponent is dashing in. Bait the opponents sp1 (ideally a short animation special opponent like captain America or captain marvel) and use sp2 only. Before using sp2 make sure the opponent has two physical vulnerability from either punks evade or intercept. When launching sp2, complete the swipe up/down prompts in the right time for more ruptures. Hulk battlecast relic preferred. Offensive stat focus special damage.

Quicksilver -

Cassie Lang -

Overseer -

Wave -

She-Hulk (Deathless) -

Blue Marvel -

These champions are the absolute worst in their class that can still technically pull through a 35 challenge rating disadvantage fight. They require either a fight like rocket raccoon or spider man stark enhanced and still need perfect AI to have a fighting chance

High Evolutionary-

Sandman - parry Heavy parry five hit combo parry heavy parry combo then combo twice to reach a total of 20 resistance and trigger unstoppable. Find an opening to use a heavy attack against the opponent either by punishing a special attack or using unstoppable like a counterpunch charge.  Use four heavy attacks total before throwing special 3. Resistance passives and unstoppable will be active again so use four heavy attacks  again. Use five hit combo into relic into five hit combo and throw sp2. This will bring you to the unstoppable again and use heavy attacks and kill th e opponent. This works best against an opponent with short special attack animations like Deadpool or venompool. Hulk battle cast relic preferred. Offensive stat focus critical rating. 

Mr. Fantastic -

Mr. Negative - 

Rhino - 

Anti-Venom -

Green Goblin (Stellar Forged) -

These champions are incapable of a win in a 35 challenge rating disadvantage fight. Nothing is saving them

These champions are not available at the seven star rarity...at least not yet