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Mister Fantastic
Invisible Woman
... DO US PART
Mister Fantastic: Debuffs last 25% longer.
Unique Synergy: Does not stack with duplicate synergies.
The Hood
Abomination
King Groot
Ronan
Vulture
...BUT THE BEST VILLAIN
The Hood: Invisibility’s starting Miss Chance is 140% instead of the normal 120%.
Villain Champions: +3% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Vulture
Sentry
Ultron
War Machine
...TIME WE CHANGED TOO
Vulture: Gain +5% Attack Rating & Immunity to Poison effects.
Other Synergy Champions: +5% Attack Rating & +15% Buff Duration.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Deadpool
Deadpool (X-Force)
Goldpool
Platinum Pool
1. START WITH FRESH DEADPOOL
Venompool: When the Cookin' Meter hits 100, 40% chance to gain a Regeneration Buff, recovering 5% of Max Health over 15 seconds.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Lady Deathstrike
Anti-Venom
12 INCH NAILS
Lady Deathstrike: While Relentless and Ferocity Passives are active, striking into the Opponent’s block with Basic Attacks Passively grants 1.1% of Max Power.

Anti-Venom: Special 2 refreshes the Evolved Mutation Passive and has a 50% chance to not consume Genetic Memory Debuffs when gaining Fury Passives.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Strange
Wong
177A BLEECKER STREET
Doctor Strange: Fate Seal Duration increased by 50%.

Wong: Maximum Eldritch Energy increased to 125.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Ham
Spider man (Miles Morales)
2 DAYS? TRY 30 YEARS!
Spider-Ham: Spider-Nonsense resets to +3 more than it would normally.

Spider man (Miles Morales): Completing a Spider-Challenge grants a Fury Passive, granting +20% Attack Rating for 16.10 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Daredevil (Classic)
Daredevil (Hell's Kitchen)
Falcon
Spider-Man (Stealth-Suit)
2. ACCURATELY MEASURE INGREDIENTS
Venompool: +300 Critical Rating for each Unique Buff.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Agent Venom
Symbiote Supreme
Venom
Venom The Duck
3. BLEND IN SYMBIOTE
Venompool: Start the fight with 1 Blender Buff activated.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Captain America
Captain America (Infinity War)
Captain America (WWII)
4. ADD PLAIN WHITE FLOUR
Venompool: Gain +3% Perfect Block Chance for each Buff on Venompool. Max Bonus +21%.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Human Torch
Red Hulk
Sunspot
5. FRY IN SKILLET
Venompool: Illogical DNA grants Immunity to Incinerate effects.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Bishop
Cable
Kang the Conqueror
Nimrod
6. ADJUST COOKING TIMER
Venompool: Gain Cookin' Meter every 3 seconds instead of every 5.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Iceman
Vision (Aarkus)
7. ALLOW TO COOL
Venompool: When the Cookin' Meter hits 100, 75% chance to gain an Ice Armor Buff, granting +2000 Armor Rating and Stun Immunity for 20 seconds. Ice Armor is lost once it prevents a Stun effect.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venompool
Hulk
Hulk (Immortal)
Ronan
Thor (Jane Foster)
8. MUNCH STUNNING FOOD
Venompool: Special 2 Stun effect is expanded to Special 1 and Special 3.
Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
Mister Negative
The Hood
A BEING DARKER THAN I
Dormammu: Gaining Dark Energy has a 10% chance to trigger a Fury Buff, granting 20% Attack Rating for 9 seconds.

Mister Negative: When inflicting Delirium there is a 50% chance to also inflict an Enervate Debuff for 2 seconds, preventing the Opponent from gaining Power when struck.

The Hood: Heavy Attacks place an Energy Vulnerability Debuff on the Opponent, reducing Energy Resistance by 700 for 8 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Wolverine (Weapon X)
Old Man Logan
Wolverine
Wolverine (X 23)
A GANG OF...
Wolverine, Wolverine (Old Man Logan), Wolverine (Weapon X), Wolverine (X-23) - Regen Buffs grant +15% Attack.
Unique Synergy: Does not stack with duplicate synergies.
Misty Knight
Valkyrie
A NIGHT TO REMEMBER
Misty Knight: Spending Anti-Metal or Cryogenic Charges pauses active Equilibrium Buffs for 11 second(s).

Valkyrie: While Valkyrie has an equal number of Pierce and Bulwark Buffs, she becomes Unstoppable while charging her Heavy Attack.
Unique Synergy: Does not stack with duplicate synergies.
Human Torch
Iceman
A SONG OF FIRE AND ICE
Human Torch and Iceman - When the Opponent takes Energy damage, they take an additional burst of Energy damage equal to 15% of the original damage.
Unique Synergy: Does not stack with duplicate synergies.
Black Widow (Claire Voyant)
Doctor Strange
A SPELL A DAY KEEPS THE DOCTOR AWAY
Black Widow (Claire Voyant): The final hit of Special 2 has a 50% chance to inflict Stun for 2 seconds.

Doctor Strange: The final hit of Special 2 has a 50% chance to inflict Stun for 2 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Spider Man 2099
Iron Man
Scarlet Witch (Classic)
Spider Man (Stark Enhanced)
A.I ENTHUSIASTS
Spider Man 2099: Second Medium attacks have a 25% chance to trigger Spider-Man 2099 Debuff Pausing ability.

Iron Man: Heavy Attack inflicts a Power Drain, removing 50% of the Opponent’s current power over 5 second(s). This effect has a 20 second(s) cooldown.

Scarlet Witch (Classic): When granting a Buff on herself, gain 15% of a Bar of Power over 3 second(s).

Spider Man (Stark Enhanced): On a Well Timed Block 33% chance to gain a Bulwark Passive, granting 700 Block Proficiency for 10 second(s).
Unique Synergy: Does not stack with duplicate synergies.