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Two Sides of a Coin

Count Nefaria
Iron Man
Count Nefaria : Whenever an Energy Build Up is inflicted, also inflict a 15% Decelerate Debuff lasting 18 seconds.

Iron Man : Whenever a Prowess is Invalidated, gain an Armor Up Buff.

Unique Synergy: Does not stack with duplicate synergies.

TWO SIDES OF THE COIN

Guillotine (Deathless)
Guillotine
Guillotine (Deathless) : Souls last 30% longer and are paused during either Champion's Special Attacks.

Guillotine : The potency of healing from damage taken by the Opponent is increased by 66.6%.

Unique Synergy: Does not stack with duplicate synergies.

Ultimate Teammates

White Tiger
Iron Fist
Luke Cage
Nova
Spider-Man (Classic)

Synergy Champions: Gain +4% Perfect Block Chance for each unique Synergy Champion on the team. If all Synergy Champions are present, also gain +30% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Umbral Vanguard

Thanos (Deathless)
Guillotine (Deathless)
King Groot (Deathless)
Vision (Deathless)
She-Hulk (Deathless)
Guillotine (Deathless) : On activation, Special 1 inflicts a non-stacking 150% Neutralize Passive for 15 seconds.

King Groot (Deathless) : When struck by an Unblockable attack, spend one Fury Buff to gain an Unstoppable Passive for 3 seconds.

Vision (Deathless) : Personal Fury max stack increases by +6, and their pause is increased by +5 seconds.

She-Hulk (Deathless) : Punishing the Opponent’s Special or Heavy Attacks grants a Grit Buff for 10 seconds.

Unique Synergy: Does not stack with duplicate synergies.
Synergy Champions: In the Necropolis, gain +50 Vengeance Charges. If all Champions are present:

UNACCEPTABULL

Rintrah
M.O.D.O.K.
Rintrah : Inflict 4 Rupture Debuffs dealing 15% Attack Rating as Physical Damage over 15 second(s) on last hit of Special 1.

M.O.D.O.K. : On landing a Critical Hit, if both a personal Incinerate and Bleed on Opponent, pause them for 6 second(s).

Unique Synergy: Does not stack with duplicate synergies.

UNCANNY AVENGERS

Havok
Captain America
Wasp
Havok : Well Timed Blocks grant +1 Plasma Charge.

Captain America : Passively increases Attack by 20% of Base Attack when Striking a Debuffed Opponent.

Wasp : When Wasp charges a Heavy Attack while hitting with a Basic Attack Combo, she gains a Passive Fury Effect increasing her Attack by 50% of her Base Attack for 3 seconds.

Unique Synergy: Does not stack with duplicate synergies.

UNCHAINED

Morningstar
Purgatory
Morningstar : +50% Ability Power Rate while below 1 Bar of Power.

Purgatory : Inflict a Soul Neutralize every 25 seconds.

Unique Synergy: Does not stack with duplicate synergies.

UNDER THE WEATHER

Storm (Pyramid X)
Storm
Storm (Pyramid X) : Alternate Tempests activated by Storm's Special 3 last 8 seconds longer.

Storm : Gain Immunity to Incinerate and Coldsnap effects. Each time an Immunity prevents one of these effects, gain 2 Prowess Buff(s).

Unique Synergy: Does not stack with duplicate Synergies.

UNDERSTANDING EVIL

Captain Britain
Unstoppable Colossus
Thing

All Non-Villian Champions, gain 10% Attack Rating, 5% Physical Resistance, 5% Energy Resistance vs. Villains.
Unique Synergy: Does not stack with duplicate synergies.

UNENDING AMBITION

Diablo
Kingpin
Loki
Red Skull
Diablo : Personal Poison Debuffs become Passive and gain +10% Potency.

Kingpin : Gain 1 Rage each time the opponent Nullifies a Buff.

Loki : +35% Curse Debuff duration.

Red Skull : 35% Shock Debuff Potency.

Unique Synergy: Does not stack with duplicate synergies.

United By Chance

Werewolf By Night
Morbius
Ghost Rider
Elsa Bloodstone
Man-Thing
Punisher
Werewolf By Night : Start each fight with a 10% Vicious Passive for 30 seconds.

Morbius : Start each fight with a 10% Vicious Passive for 30 seconds.

Ghost Rider : Start each fight with a 10% Vicious Passive for 30 seconds.

Elsa Bloodstone : Start each fight with a 10% Vicious Passive for 30 seconds.

Man-Thing : Start each fight with a 10% Vicious Passive for 30 seconds.

Punisher : Gain this synergy’s bonus after taking a Lethal Blow during the Quest.

Legion of Monsters Champions (Morbius, Ghost Rider, Elsa Bloodstone, Man-Thing): Start each fight with a 10% Vicious Passive for 30 seconds.
Unique Synergy: Does not stack with duplicate synergies.

UNLIKELY COMBINATION

Ant-Man
Ronin
Ant-Man : Increase the Potency of Poisons by 20%.

Ronin : Gain +25% Block Proficiency in Guard Stance.

Unique Synergy: Does not stack with duplicate synergies.

UNMERCIFUL PUNISHMENT

Proxima Midnight
Nebula
Proxima Midnight : When True Accuracy is active, her Attack Rating is increased by 15%.

Nebula : Starts the fight with 10 Electroshock Charges.

Unique Synergy: Does not stack with duplicate Synergies.

UNREQUITED ROMANCE

Sersi
Captain America
Captain America (Infinity War)
Sersi : Start the fight with an indefinite Armor Up increasing Armor Rating by [30, 60, 100].

Solo Synergy: Only affects this Champion and does not stack.

UNTAMED FORCE

Sabretooth
Old Man Logan
Sabretooth : 20% chance for his low-kick first Medium Attack to be Unblockable. Additionally, If the opponent activates an unstoppable effect as a result of this attack, it expires instantly.

Old Man Logan : +120% Regeneration Rate when hitting opponents.

Unique Synergy: Does not stack with duplicate synergies.

USAPHO

Shuri
Black Panther
Black Panther (Civil War)

Synergy Members: Gain +10% Health and +10% Shock and Bleed potency.
Unique Synergy: Does not stack with duplicate synergies.

UTSHABA

Shuri
Attuma
Namor

Synergy Members: Start each fight with 10 indefinite Precision Passives. These don't count as Precisions and are consumed by Light and Medium hits to become Guaranteed Critical Hits.
Unique Synergy: Does not stack with duplicate synergies.

VESSELS OF DARKNESS

Knull
Red Goblin
Symbiote Supreme
Venom
Venom The Duck
Knull : When the Opponent is immune to an effect, Knull gains a Fury Buff, increasing Attack Rating by 35% for 16 seconds. Max 1 stack(s).

Solo: Only affects this Champion and does not stack.

Vibranium Club

Gentle
Captain America (Sam Wilson)
Captain America (Infinity War)
Misty Knight
Gentle : Increase the Ability Accuracy of Muscle Mass by 25%.

Captain America (Sam Wilson) : Increase the Ability Accuracy of personal Armor Ups by 25%.

Captain America (Infinity War) : Increase the Ability Accuracy of personal Debuffs by 25%.

Misty Knight : Increase the Ability Accuracy of personal Purifies and Evades by 25%.

VICIOUS KITTY

Kitty Pryde
Tigra
Kitty Pryde : While 10+ Prowess are active, become Passively Unblockable while Phased.

Tigra : Neutralize effects last +35% longer.

Unique Synergy: Does not stack with duplicate synergies.