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Titania
Colossus
Drax
Hulk
Hyperion
TitaniaIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

ColossusIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

DraxIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

HulkIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

HyperionIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

DISPLAY OF STRENGTH

Cull Obsidian
Ebony Maw
Thanos
Cull ObsidianNew Mission: Show your Might: Knockout a Champion while the Rout Buff is active. This mission can only be completed once each Quest.

Solo: Only affects this Champion and does not stack.

DINKY SHRINKS

Ant-Man
Psycho-Man
Wasp
Yellow Jacket
Ant-ManSpecial Attack 1 inflicts the Opponent with 2 Stagger Debuffs for 12 second(s).

Psycho-ManHeavy Attacks grant a non-stacking Armor Up Buff, increasing Armor Rating by +600 for 10 second(s).

Wasp+1200 Block Proficiency.

Yellow JacketWhen the Opponent fills a Bar of Power, they gain a Power Sting Debuff for 8 seconds, dealing 30% of Yellowjacket's Attack as Direct Damage.

Unique Synergy: Does not stack with duplicate synergies.

DIMENSIONAL BUDDIES

Purgatory
Dormammu
Magik
Mephisto
The Hood

#DimensionalBeings: Gain Bleed Immunity, 20% increased Ability Accuracy, and +900 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.

DIFFERENT BUT THE SAME

Omega Sentinel
Omega Red
Omega SentinelFor each Armor Up consumed during a Special Attack, inflict an Armor Break Debuff reducing Armor Rating by 10% for the duration of that Special Attack.

Solo Synergy: Only affects this Champion and does not stack.

DEMONS

Mephisto
Dormammu
Mephisto+80% Energy Resistance while taking Damage over time.

Dormammu+80% Energy Resistance while taking Damage over time.

Unique Synergy: Does not stack with duplicate synergies.

Demonic Pact

Dormammu
Mephisto
Scarlet Witch (Sigil)
DormammuImbued Attacks have 1250 increased Attack Rating.

MephistoWhile the Opponents Soul is Imprisoned, 100% chance to activate Aura of Incinerate when the Opponent fails to gain a Buff through Chance. Cooldown 1 second.

Scarlet Witch (Sigil)Chaos Surge creates Regeneration instead of Prowess, granting 4% of missing health over 12 seconds. Prowess can no longer be copied, but Regeneration can.

Dimensional Beings: +15% increased Ability Power Rate.
Unique Synergy: Does not stack with duplicate Synergies.

DEMON HUNTER

Blade
Mephisto
Dormammu
BladeDanger Sense bonuses expand to include all Mystic Champions. Danger Sense's Ability Accuracy reduction does not ignore the Immunities from Mystic Champions.

MephistoOpponent's Energy Resistance is reduced by -950.

DormammuOpponent's Energy Resistance is reduced by -950.

Unique Synergy: Does not stack with duplicate synergies.

DEICIDE

Gorr
Thor
Thor (Ragnarok)
Thor (Jane Foster)
GorrShadow Magic Buff duration increased by 2 second(s).

Solo Synergy: Only affects this Champion and does not stack.

DEFENDERS DESTROYER

Elektra
Kingpin
Iron Fist
Iron Fist (Immortal)
Luke Cage
Elektra+25% Bleed Ability Accuracy & duration.

KingpinEnter the fight with 2 Rage.

Iron Fist+25% Armor Break duration and Potency.

Iron Fist (Immortal)+25% Armor Break duration and Potency.

Luke CageUp to +60% Attack Rating based on Physical Resistance.

Unique Synergy: Does not stack with duplicate synergies.

DECIMATION

Sabretooth
Magneto
Magneto (House of X)
Scarlet Witch (Classic)
SabretoothStarts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

MagnetoStarts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto (House of X)Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Scarlet Witch (Classic)Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Unique Synergy: Does not stack with duplicate synergies.

Decimation

Scarlet Witch (Sigil)
Cyclops (New Xavier School)
Emma Frost
Storm
Wolverine
Scarlet Witch (Sigil)Copied Buffs have 25% increased duration.

All Champions: Mutant Opponents have 30% reduced Ability Accuracy during either Champions Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.

DEATHWISH

Platinum Pool
Doctor Doom
Platinum PoolIncrease the chance to draw the Sumopool Card.

Solo: Only affects this Champion and does not stack.

DEATH TO VALHALLA

Gorr
Mangog
GorrWhile the Opponent is inflicted with at least 15 damaging Debuffs, gain an indefinite True Damage Buff.

MangogWhile Enrage is active, the burst of Energy Damage from Heavy Attack charges twice as fast.

Unique Synergy: Does not stack with duplicate synergies.

DEATH AND RESURRECTION

Phoenix
Terrax
PhoenixThe durations of the Buffs granted by Rite of the Phoenix are increased by 50%.

TerraxWell-timed blocks give Terrax +3% of a Bar of Power.

Unique Synergy: Does not stack with duplicate synergies.

DEAR SISTER

QuickSilver
Scarlet Witch (Classic)
Scarlet Witch (Sigil)
QuickSilverThe first Special Attack after reaching Max Momentum Charges has its Attack Power increased by 70%.

Scarlet Witch (Classic)When Veil of Fortune Triggers, 50% chance to gain a Prowess Buff, granting 100% Special Attack Damage for 15 second(s).

Scarlet Witch (Sigil)When gaining one Instability Gain a Prowess Buff, granting 50% Special Attack Damage for 15 second(s).

Unique Synergy: Does not stack with duplicate synergies.

DEAL WITH IT

Jubilee
Doctor Octopus
Falcon
Hawkeye
Hit-Monkey

Synergy Members: +10% Max Health.
Unique Synergy: Does not stack with duplicate synergies.

DEADLY STING

Wasp
Yellow Jacket
WaspWhen she intercepts the opponent’s Dash Attack and Concussion is not active on the opponent, Concussion is inflicted, reducing the opponent’s Ability Accuracy by 100% for 8 seconds. This can activate 3 times in a fight.

Yellow Jacket40% chance to reactivate a Power Sting when it’s timer expires.

Unique Synergy: Does not stack with duplicate Synergies.

DEADPOOL'S GUIDE TO SUPER VILLAINS

Squirrel Girl
Deadpool
Squirrel GirlSquirrel Girl reads Deadpool’s Guide to Super Villains cards to gain an advantage, increasing her Attack Rating by 10% while fighting Villain Champions.

Solo: Only affects this Champion and does not stack.

DAVID AND GOLIATH

Ægon
The Champion
ÆgonÆgon gets +20% Attack Rating while fighting larger Champions.

The ChampionThe Champion gets +20% Attack Rating while fighting smaller Champions

Unique Synergy: Does not stack with duplicate synergies.