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With Your Heart in Your Hand

Wolverine (X 23)
Wolverine
Wolverine (X 23)While Laura’s personal Regeneration is active, personal Bleed, Rupture, and Cruelty effects expire 20% slower.

WolverineIntercepting the Opponent grants a +20% Precision Buff for 12 seconds. Max stacks: 3.

Unique Synergy: Does not stack with duplicate synergies.

A Good Lie

Punisher
Franken-Castle
PunisherHeavy Attack inflicts a non-stacking Incinerate Debuff dealing 120% of Attack as Energy Damage over 15 seconds.

Franken-CastleWhen Franken-Castle drops to 1% Health, he gains an Indestructible Passive and deals Guaranteed Critical Hits for 5 seconds.

Unique Synergy: Does not stack with duplicate synergies.

The Founder’s Military Might

Isophyne
Lumatrix
Solvarch
Imperiosa
IsophyneAt the start of each fight, Isophyne's Opponent is inflicted with their personal Degeneration Passive, lasting for half of its base duration.

Solo: Only affects this Champion and does not stack.

Cosmic Forces of The Contest

Imperiosa
King Groot
King Groot (Deathless)
Venompool
Venom The Duck
Galan
ImperiosaSynthect Pierce potency increased by 20%.

King GrootPause Furies during Groot’s Specials.

King Groot (Deathless)Pause Furies during Groot’s Specials.

VenompoolInflict a 50% Infuriate Passive while Venompool is outside striking distance and has 2 or more Bars of Power.

Venom The DuckGain +500 Armor Penetration while the Opponent has Toxic Armor.

GalanSpecial Attack 3 grants +100 Planetary Mass.

Unique Synergy: Does not stack with duplicate synergies.

Many-Armed Menaces

Imperiosa
Doctor Octopus
Spiral
ImperiosaGain personal Special Lock Immunity after Dodging a Basic Attack.

Doctor OctopusIncrease personal burst damage potency by 15%.

SpiralIncrease the Resistance gained from Fervor by 300%.

Unique Synergy: Does not stack with duplicate synergies.

Hive Minds Think Alike

Imperiosa
Ant-Man (Future)
Ant-Man
Knull
Shathra
ImperiosaAt the start of each fight, inflict a 60% Infuriate Passive for 5 seconds.

Ant-Man (Future)At the start of each fight, inflict a 60% Infuriate Passive for 5 seconds.

Ant-ManWhen Ant-Man is Immune to one or more Damaging effects, he gains 1 Pym Particle.

KnullArmor Break Debuff duration increased by 50%.

ShathraStart each fight with 30 Astral Wasps on the Opponent.

Unique Synergy: Does not stack with duplicate synergies.

Combined Genius of the Founders

Imperiosa
Isophyne
Lumatrix
Solvarch
ImperiosaStart each fight with 90% of Max Power.

Solo: Only affects this Champion and does not stack.

Chai Time

Spider-Man (Pavitr Prabhakar)
Doctor Strange
Nico Minoru
Doctor Voodoo
Sersi
Scarlet Witch (Classic)

Synergy Champions: At the start of each fight, rapidly gain 50% of a Bar of Power.
Unique Synergy: Does not stack with duplicate synergies.

Rescue Mission: Distraction

Spider-Man (Pavitr Prabhakar)
Spider-Ham
Spider-Punk
Spider-HamWhen the Opponent is Immune to Stun, pause personal Porker-Poppers for 2 seconds.

Spider-PunkGain +1000 Physical Resistance while Unstoppable.

#Spider-Verse Heroes: +3% Health.
Unique Synergy: Does not stack with duplicate synergies.

Rescue Mission: Infiltration

Spider-Man (Pavitr Prabhakar)
Spider-Gwen
Peni Parker
Spider-Man (Pavitr Prabhakar)Canceling a Heavy Attack with a Special Attack inflicts a personal Energy Vulnerability.

Spider-GwenCombo-Ending Attack pause is increased by +1 second.

Peni ParkerLanding hits pauses her personal Heal Block for 0.3 seconds.

#Spider-Verse Heroes: +3% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Cannon Event

Spider-Man (Pavitr Prabhakar)
Rocket Raccoon
Negasonic Teenage Warhead
Hit-Monkey
Mantis
Wiccan
Spider man (Miles Morales)

Synergy Champions: Start each fight with a Glass Cannons Anonymous Buff, granting +3000 Armor and +650 Critical Resistance for 2 seconds. This Buff is paused until struck.
Unique Synergy: Does not stack with duplicate synergies.

Which Universe Are You Again?

Spider-Man (Pavitr Prabhakar)
The Maker
The Overseer
Shathra
Spider-Man (Pavitr Prabhakar)While the Opponent has more than 2 Bars of Power, inflict a Passive 65% Wither Debuff.

The MakerWhile charging or releasing a Heavy Attack, Evade the first incoming Basic Attack. Cooldown: 20 seconds.

The OverseerWhile the Opponent has more than 2 Bars of Power, inflict a 65% Wither Debuff.

ShathraWhile charging or releasing a Heavy Attack, Evade the first incoming Basic Attack. Cooldown: 20 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Mean Greens

Lizard
Sauron
Man-Thing
LizardWhen the Opponent is inflicted with a non-Damaging Debuff other than the Parry Mastery Stun, inflict a personal Rupture.

SauronIf the Opponent Purifies or Cleanses the Parry Mastery Stun, gain an Unstoppable Passive for 1 second.

Man-ThingEach hit of Special 2 Nullifies 1 extra Buff.

Unique Synergy: Does not stack with duplicate synergies.

Crazy Scientists

Lizard
M.O.D.O.K.
Mister Sinister
The Overseer
LizardPersonal Unstoppable lasts +2 seconds.

M.O.D.O.K.At the end of Special 1, inflict a non-stacking 100% Petrify Debuff for 4 seconds.

Mister SinisterWhen the Opponent fails to Purify one or more Debuffs due to reduced Ability Accuracy, self-inflict a personal Bleed Debuff.

The OverseerAgainst Mystic Champions, gain a Steadfast Passive while at or above 3 Gamma Power.

Unique Synergy: Does not stack with duplicate synergies.

Just Another Sinister Six

Lizard
Electro
Kraven
Mysterio
Doctor Octopus
Sandman

Synergy Champions: When fighting against #Spider-Verse Heroes, on Special Attack activation, gain a Pursuit Passive for 13 seconds.
Unique Synergy: Does not stack with duplicate synergies.

Everyone Must Be Lizards!

Lizard
Spider-Man (Classic)

All Champions gain a Lizard Regeneration Passive at the start of each fight, granting +600 Attack Rating and recovering 2% of Base Health over 20 seconds.
Synergy Champions: Increase the amount healed by Lizard Regeneration by +3% flat.
Unique Synergy: Does not stack with duplicate synergies.

Pull The Lever!

Franken-Castle
Mole Man

Synergy Champions: 10% increased Shock and Incinerate Debuff duration.
Unique Synergy: Does not stack with duplicate synergies.

What Real Monsters Are!

Franken-Castle
Morbius
Werewolf By Night

#Legion of Monsters Champions: At the start of each fight, gain an indefinite 20% Fervor Passive.
Unique Synergy: Does not stack with duplicate synergies.

Stapled Together Mess

Franken-Castle
Venompool
Franken-CastleGaining Frank’s Rage Debuff now also grants 2 hits to his Combo Meter.

VenompoolVenompool’s Illogical DNA abilities now work against all non-Mystic and non-Superior Champions.

Unique Synergy: Does not stack with duplicate synergies.

Bloodgem Corruption

Franken-Castle
Elsa Bloodstone
Franken-CastleWhile not Unstoppable, Frank gains +115 Critical Damage Rating for each of his Berserk Passives.

Elsa BloodstoneDuring Elsa’s Heavy or Special Attacks while not Reloading Hellfire Rounds, double tapping Block swaps their effects between Incinerates and Coldsnaps.

Unique Synergy: Does not stack with duplicate synergies.