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ENGINEERING EXPERTS

Black Panther (Civil War)
Black Panther
Hulkbuster
Mister Fantastic
Black Panther (Civil War)+40% Armor Up Ability Accuracy and Potency.

Black Panther+25% Bleed Debuff Duration.

HulkbusterEach Shock Debuff reduces the opponent’s Offensive Ability Accuracy during Special Attacks by 15%.

Mister Fantastic+1000 Physical Resistance.

Unique Synergy: Does not stack with duplicate Synergies.

ENGINEERING

Doctor Octopus
Vulture
Doctor OctopusResearch Categories no longer fall off over time.

VultureGain an additional +5 Chitauri Charge on Critical Hit.

Unique Synergy: Does not stack with duplicate synergies.

ENERGY CONDUIT - Cyclops

Bishop
Cyclops (Blue Team)
Cyclops (New Xavier School)
BishopStart the fight with +[1, 2] Prowess and +1 Bar of Power.

Cyclops (Blue Team)+[10, 15]% Energy Resistance.

Cyclops (New Xavier School)+[10, 15]% Energy Resistance.

ENERGY CONDUIT - Doctor Strange

Bishop
Doctor Strange
BishopStart the fight with +[1, 2] Prowess and +1 Bar of Power.

Doctor Strange+[10, 15]% Energy Resistance.

ENERGY CONDUIT - Electro

Bishop
Electro
BishopStart the fight with +[1, 2] Prowess and +1 Bar of Power.

Electro+[10, 15]% Energy Resistance.

ENERGY CONDUIT - Storm

Bishop
Storm
BishopStart the fight with +[1, 2] Prowess and +1 Bar of Power.

Storm+[10, 15]% Energy Resistance.

ENERGY ABSORPTION

Bishop
Havok
Mangog
Bishop+25% Regeneration Rate and +30% Prowess potency. Once per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.

Havok+5% Combat Power Rate and +20% Ability Power Rate. Once per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.

MangogOnce per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.

Unique Synergy: Does not stack with duplicate synergies.

ENEMY OF ALCHEMAX

Scorpion
Spider Man 2099
ScorpionIf Scorpion-Sense is active and Scorpion is Stunned, Scorpion’s Evade Ability Accuracy is increased to 100%.

Spider Man 2099When Striking the Opponent's Block, each Wither Debuff on the Opponent has 50% chance to inflict an additional Rupture.

Unique Synergy: Does not stack with duplicate synergies.

ENEMIES OF THE MYSTICAL REALM

Dormammu
Rintrah
Vision (Aarkus)
DormammuAfter Adding 1 Detonation Charge by Heavy Attack, Light attacks have a 30% chance to add 10 Detonation Charges.

RintrahStart the Fight with 5 Mystical Charges.

Vision (Aarkus)Increase Coldsnap Debuff damage by 50%.

Unique Synergy: Does not stack with duplicate synergies.

ENCROACHING INSANITY

Mysterio
Daredevil (Classic)
Daredevil (Hell's Kitchen)
MysterioPoison durations are increased by 2 seconds.

Solo: Only affects this Champion and does not stack.

ENCHANTED BLADES

Guillotine
Magik
Heimdall
GuillotineOnce per fight Heimdall will intercede on your behalf, dash back and hold Block for 1.5 seconds to gain an infinite Duration Precision Buff increasing Critical Rate by 250.

MagikOnce per fight Heimdall will intercede on your behalf, dash back and hold Block for 1.5 seconds to gain an infinite Duration Precision Buff increasing Critical Rate by 250.

Unique Synergy: Does not stack with duplicate synergies.

ELEMENTAL HIDE

Iceman
Korg
IcemanWhile Ice Armor is reforming, Iceman’s Attack Rating is increased by 15% as long as he does not get hit.

KorgIf Korg is awakened, +15% chance to shrug off a Debuff while Rock Shield is active.

Unique Synergy: Does not stack with duplicate Synergies.

ELECTRIC SUPERCHARGE

Electro
Green Goblin
ElectroWhile under a Shock Debuff, +30% Attack.

Green Goblin+20% Bag of Tricks Potency.

Unique Synergy: Does not stack with duplicate synergies.

ELDERS’ GAME

Mordo
Red Hulk
Terrax
MordoWhile charging a Heavy Attack, if the Opponent attacks, Mordo will evade. This ability has a 25 second cooldown.

Red HulkWhen hitting the Opponent with his first Heavy Hit, Red Hulk consumes a Heat Charge and inflicts an Armor Break Debuff, reducing the Opponent’s Armor Rating by 50% for 8 seconds.

TerraxGain +15% chance to Armor Break during his Rock Field.

Unique Synergy: Does not stack with duplicate synergies.

EASTERN BLOCKERS

Abomination
Rhino
Red Guardian
AbominationAttacks have a 50% chance to inflict Poison, dealing 70% of modified Attack over 10 seconds.

RhinoStarts the fight with a Passive Fury granting +30% Attack Rating for 20 seconds. While this Fury is active Rhino also gains +50% increased Ability Accuracy and inflicts the Opponent with a Slow Debuff.

Unique Synergy: Does not stack with duplicate synergies.

DRY ICE

Iceman
Mysterio
Vision (Aarkus)
IcemanIncrease the duration of Frostbite Passives by 4 second(s) flat.

MysterioIncrease the duration of Reflection and Frenzy gas by 3 second(s) flat.

Vision (Aarkus)Increase the duration of Armor Break Debuffs by 2 second(s) flat.

Unique Synergy: Does not stack with duplicate synergies.

DRUG M

Iceman
Magneto (House of X)
Magneto
Professor X
IcemanInflict 3 personal Frostbite Passives whenever the Opponent Purifies a Coldsnap Debuff.

Magneto (House of X)Guidance's bonus Attack Rating is increased by a flat +5% or +15% on the final node of a Quest.

Magneto+15% Attack Rating while fighting #Metal Champions.

All Mutants and X-Men except Professor X: Gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge. Max 10% Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health.
Unique Synergy: Does not stack with duplicate synergies.

DRUG L

Cyclops (New Xavier School)
Cyclops (Blue Team)
Phoenix
Professor X
Cyclops (New Xavier School)Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.

Cyclops (Blue Team)Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.

PhoenixThe stack limit for personal Fury Buffs is increased by 3.

All Mutants and X-Men except Professor X: Once per fight when a Champion would be knocked out, immediately regenerate 7.5% of their Max Health for each Cerebro Charge. Max 30% Health.
Unique Synergy: Does not stack with duplicate synergies.

DRUG I

Colossus
Wolverine
Wolverine (X 23)
Professor X
ColossusStart each fight with 1 indefinite Armor Up Buff, granting +15% Armor Rating.

Wolverine+15% Critical Rating.

Wolverine (X 23)+15% Critical Rating.

All Mutants and X-Men except Professor X: +18% Poison Resistance for each Cerebro Charge. Max 72%.
Unique Synergy: Does not stack with duplicate synergies.

DRESSED FOR A FUNERAL

Agent Venom
Scorpion
Venom
Agent VenomWhen inflicting the Opponent with Bleed, also inflict an Incinerate Debuff, reducing Block Proficiency by 50% and dealing 220% of Attack in Energy Damage over 4 second(s).

ScorpionGain a Fury Passive for each Sting Debuff on the Opponent, increasing Attack Rating by 10%.

VenomGain 25 Power per Unique Buff over 5 seconds whenever Venom gains a Genetic Memory Buff.

Unique Synergy: Does not stack with duplicate synergies.