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ELEMENTAL HIDE

Iceman
Korg
IcemanWhile Ice Armor is reforming, Iceman’s Attack Rating is increased by 15% as long as he does not get hit.

KorgIf Korg is awakened, +15% chance to shrug off a Debuff while Rock Shield is active.

Unique Synergy: Does not stack with duplicate Synergies.

ELECTRIC SUPERCHARGE

Electro
Green Goblin
ElectroWhile under a Shock Debuff, +30% Attack.

Green Goblin+20% Bag of Tricks Potency.

Unique Synergy: Does not stack with duplicate synergies.

ELDERS’ GAME

Mordo
Red Hulk
Terrax
MordoWhile charging a Heavy Attack, if the Opponent attacks, Mordo will evade. This ability has a 25 second cooldown.

Red HulkWhen hitting the Opponent with his first Heavy Hit, Red Hulk consumes a Heat Charge and inflicts an Armor Break Debuff, reducing the Opponent’s Armor Rating by 50% for 8 seconds.

TerraxGain +15% chance to Armor Break during his Rock Field.

Unique Synergy: Does not stack with duplicate synergies.

EASTERN BLOCKERS

Abomination
Rhino
Red Guardian
AbominationAttacks have a 50% chance to inflict Poison, dealing 70% of modified Attack over 10 seconds.

RhinoStarts the fight with a Passive Fury granting +30% Attack Rating for 20 seconds. While this Fury is active Rhino also gains +50% increased Ability Accuracy and inflicts the Opponent with a Slow Debuff.

Unique Synergy: Does not stack with duplicate synergies.

DRY ICE

Iceman
Mysterio
Vision (Aarkus)
IcemanIncrease the duration of Frostbite Passives by 4 second(s) flat.

MysterioIncrease the duration of Reflection and Frenzy gas by 3 second(s) flat.

Vision (Aarkus)Increase the duration of Armor Break Debuffs by 2 second(s) flat.

Unique Synergy: Does not stack with duplicate synergies.

DRUG M

Iceman
Magneto (House of X)
Magneto
Professor X
IcemanInflict 3 personal Frostbite Passives whenever the Opponent Purifies a Coldsnap Debuff.

Magneto (House of X)Guidance's bonus Attack Rating is increased by a flat +5% or +15% on the final node of a Quest.

Magneto+15% Attack Rating while fighting #Metal Champions.

All Mutants and X-Men except Professor X: Gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge. Max 10% Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health.
Unique Synergy: Does not stack with duplicate synergies.

DRUG L

Cyclops (New Xavier School)
Cyclops (Blue Team)
Phoenix
Professor X
Cyclops (New Xavier School)Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.

Cyclops (Blue Team)Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.

PhoenixThe stack limit for personal Fury Buffs is increased by 3.

All Mutants and X-Men except Professor X: Once per fight when a Champion would be knocked out, immediately regenerate 7.5% of their Max Health for each Cerebro Charge. Max 30% Health.
Unique Synergy: Does not stack with duplicate synergies.

DRUG I

Colossus
Wolverine
Wolverine (X 23)
Professor X
ColossusStart each fight with 1 indefinite Armor Up Buff, granting +15% Armor Rating.

Wolverine+15% Critical Rating.

Wolverine (X 23)+15% Critical Rating.

All Mutants and X-Men except Professor X: +18% Poison Resistance for each Cerebro Charge. Max 72%.
Unique Synergy: Does not stack with duplicate synergies.

DRESSED FOR A FUNERAL

Agent Venom
Scorpion
Venom
Agent VenomWhen inflicting the Opponent with Bleed, also inflict an Incinerate Debuff, reducing Block Proficiency by 50% and dealing 220% of Attack in Energy Damage over 4 second(s).

ScorpionGain a Fury Passive for each Sting Debuff on the Opponent, increasing Attack Rating by 10%.

VenomGain 25 Power per Unique Buff over 5 seconds whenever Venom gains a Genetic Memory Buff.

Unique Synergy: Does not stack with duplicate synergies.

DRAG BRUNCH

Loki
Wiccan
LokiFinishing a combo with a light attack pauses Curse for 4 seconds.

WiccanLast Hit of Special 2 inflicts a Slow Debuff for 10 second(s).

Unique Synergy: Does not stack with duplicate synergies.

DOUBLE NEGATIVE

Annihilus
Darkhawk
AnnihilusWhen Striking an Auto Blocking Opponent, Annihilus gets a Taunt passive for 0.5 seconds.

DarkhawkAttack Rating increased by 9% while in any mode.

Contingency Plan: If Annihilus is fighting Darkhawk, Darkhawk's Armor Rating is decreased by 15% while in any mode.

DON'T MENTION PUNY BANNER!

Hulk (Ragnarok)
Hulk
Hulkbuster
Hulk (Ragnarok)Gains up to +1000 Physical Resistance based on how high the Crowd Meter is.

HulkImmunity to Nullify, Fate Seal and Stagger.

HulkbusterUp to +1000 Armor Rating based on how low Hulkbuster’s current Health is.

Unique Synergy: Does not stack with duplicate Synergies.

DOCTORS STRANGE

Sorcerer Supreme
Doctor Strange
Symbiote Supreme
Sorcerer SupremeGain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Doctor StrangeGain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Symbiote SupremeGain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Unique Synergy: Does not stack with duplicate synergies.

DOCTOR DESPOTS

Doctor Strange
Iron Man (Infamous)
Doctor StrangeDuring Special Attack 1, gain +40% Attack Rating.

Iron Man (Infamous)Cowardice effects gain 50% increased potency.

Unique Synergy: Does not stack with duplicate synergies.

DO YOU EVEN LIFT?

Titania
Colossus
Drax
Hulk
Hyperion
TitaniaIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

ColossusIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

DraxIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

HulkIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

HyperionIncrease the potency of Fury effects by 4% for each synergy member present. Max: 20%.

DISPLAY OF STRENGTH

Cull Obsidian
Ebony Maw
Thanos
Cull ObsidianNew Mission: Show your Might: Knockout a Champion while the Rout Buff is active. This mission can only be completed once each Quest.

Solo: Only affects this Champion and does not stack.

DINKY SHRINKS

Ant-Man
Psycho-Man
Wasp
Yellow Jacket
Ant-ManSpecial Attack 1 inflicts the Opponent with 2 Stagger Debuffs for 12 second(s).

Psycho-ManHeavy Attacks grant a non-stacking Armor Up Buff, increasing Armor Rating by +600 for 10 second(s).

Wasp+1200 Block Proficiency.

Yellow JacketWhen the Opponent fills a Bar of Power, they gain a Power Sting Debuff for 8 seconds, dealing 30% of Yellowjacket's Attack as Direct Damage.

Unique Synergy: Does not stack with duplicate synergies.

DIMENSIONAL BUDDIES

Purgatory
Dormammu
Magik
Mephisto
The Hood

#DimensionalBeings: Gain Bleed Immunity, 20% increased Ability Accuracy, and +900 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.

DIFFERENT BUT THE SAME

Omega Sentinel
Omega Red
Omega SentinelFor each Armor Up consumed during a Special Attack, inflict an Armor Break Debuff reducing Armor Rating by 10% for the duration of that Special Attack.

Solo Synergy: Only affects this Champion and does not stack.

DEMONS

Mephisto
Dormammu
Mephisto+80% Energy Resistance while taking Damage over time.

Dormammu+80% Energy Resistance while taking Damage over time.

Unique Synergy: Does not stack with duplicate synergies.