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FIRST CRUSH

Dragon Man
Invisible Woman
Dragon ManWhile Unstoppable and being attacked, Dragon Man reduces his Opponents Offensive Ability Accuracy by 50%.

Invisible WomanWhen becoming visible, retain 40% of Fragility Debuffs on the Opponent.

Unique Synergy: Does not stack with duplicate Synergies.

FIRE AND FORGET

Black Widow (Claire Voyant)
Human Torch
Mephisto
Sunspot
Black Widow (Claire Voyant)Whenever the Opponent is immune to Incinerate they’re inflicted with a Slow Debuff for 8 seconds.

Human TorchWhenever the Opponent is immune to Incinerate they’re inflicted with a Slow Debuff for 8 seconds.

MephistoWhenever the Opponent is immune to Incinerate they’re inflicted with a Slow Debuff for 8 seconds.

SunspotWhenever the Opponent is immune to Incinerate they’re inflicted with a Slow Debuff for 8 seconds.

Unique Synergy: Does not stack with duplicate synergies.

FIRE AND DRAGONS

Dragon Man
Kitty Pryde
Sauron
Dragon ManIf no Power Charges are active Special Attack 2 inflicts up to 3 additional Incinerate Debuffs.

Kitty PrydeIncrease the duration of Incinerate Debuffs by +10% and Passive Incinerates by +15%.

SauronWhen Sauron activates a Special Attack with Max Health, inflict 3 Incinerate Passives, dealing 100% Attack Rating as Energy Damage over 6 second(s). Max 6 stack(s).

Unique Synergy: Does not stack with duplicate synergies.

FIGHTING DESTINY

Hulkling
Super-Skrull
HulklingWhen striking a Tech Opponent, 15% chance per Armor Up Buff they have to gain a non-stacking Pierce Buff of 700 potency for 16 second(s).

Super-SkrullPersonal Energy Vulnerability Debuffs are paused while Attacking the Opponent.

Unique Synergy: Does not stack with duplicate synergies.

FIELD TRIP

Daredevil (Hell's Kitchen)
Mysterio
Peni Parker
Daredevil (Hell's Kitchen)Exiting Murdock Boy Mode grants a Righteous Wrath Passive for 8 second(s). While active, Basic Attacks have a 35% chance to inflict an instant Bleed, dealing 120% of hit damage as Direct Damage.

MysterioChemical Gas is not consumed when inflicting Poison with a Heavy Attack.

Peni ParkerWhile the Sync-Shield is active, Peni can trigger the Parry Mastery against non-contact attacks.

Unique Synergy: Does not stack with duplicate synergies.

FELINE POSSESSION

Black Panther (Civil War)
Black Panther
Tigra
Black Panther (Civil War)When Attacked while Reflective State is active, Black Panther has a 60% chance to gain an Armor Up Buff granting 280 Armor Rating for 7.5 seconds.

Black PantherGain an additional Cruelty Passive from all Hits.

TigraNullify any Unstoppable Buffs while the Opponent is suffering the effects of Rupture.

Unique Synergy: Does not stack with duplicate Synergies.

FEEL CYTTORAK'S EMBRACE

Colossus
Juggernaut
Unstoppable Colossus
ColossusArmor Up Buffs also grant +1% Attack Rating.

JuggernautStart the fight with 3 of his Unstoppable Buffs active.

Unstoppable ColossusGain +20% Fury and Armor Up Buff Potency.

Unique Synergy: Does not stack with duplicate synergies.

FEARSOME FOUR

Howard The Duck
Man-Thing
She-Hulk
Howard The DuckSpecial 2 gains +25% Ability Accuracy.

Man-ThingIf Struck by a Basic Attack while under the effect of an Unstoppable Buff 100% chance to gain an Indestructible Buff lasting 0.5 second(s).

She-HulkStriking a Stunned Opponent with a Heavy Attack grants a Fury Buff increasing Attack by 100% of her Base Attack for 1 second(s).

Unique Synergy: Does not stack with duplicate synergies.

FEARLESS

Killmonger
Void
KillmongerIf Vibranium Armor is active, Killmonger has a 35% chance to Purify a Debuff after a 0.5 second delay and then instantly Regenerate 4% Health per Debuff.

VoidRegenerates 1% Health when inflicting his Intimidating Debuffs.

Unique Synergy: Does not stack with duplicate Synergies.

FEAR ITSELF

Attuma
Hulk
Juggernaut
Thing
Titania
Absorbing Man
AttumaGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

HulkGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

JuggernautGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

ThingGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

TitaniaGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

Absorbing ManGain +20% Attack Rating when fighting at Class Advantage, and regain the Attack Rating penalty when fighting at Disadvantage.

Unique Synergy: Does not stack with duplicate synergies.

FATEFUL FRIENDS

Doctor Strange
Ikaris
Iron Man
Doctor StrangeThe first time Doctor Strange is struck in each fight, he gains a 5% Safeguard Buff for 10 seconds.

IkarisWhen a personal Incinerate expires naturally or is Purified, there is a 30% chance to re-inflict it.

Iron ManSpecial Attack hits inflict Incinerate Debuffs dealing 100% of Attack as Energy Damage over 3 seconds.

Unique Synergy: Does not stack with duplicate synergies.

FASTBALL SPECIAL

Colossus
Wolverine
Old Man Logan
ColossusGain a Fastball Fury Buff at the start of the fight, granting +50% Attack and +50% Special Attack rating for 15 seconds.

WolverineBegin the fight with 1 Bar of Power.

Old Man LoganBegin the fight with 1 Bar of Power.

Unique Synergy: Does not stack with duplicate synergies.

FARM TO TABLE

Colossus
Galan
Thanos
ColossusColossus’ Special Attack 1 becomes passively Unblockable when activated with 5 or more Personal Armor Up Buffs.

GalanConverting Resistances into Planetary Mass creates an additional 5 Planetary Mass per Resistance.

ThanosThe first time Thanos would be knocked out in each fight, he gains an Indestructible Buff, keeping the Mad Titan alive for 8 seconds.

Unique Synergy: Does not stack with duplicate synergies.

FANTASTIC RAGE

Doctor Doom
Annihilus
Diablo
Doctor DoomHeavy Attacks are guaranteed critical hits while the Opponent is suffering from a Stagger effect.

Solo: Only affects this Champion and does not stack.

FANTASTIC FIENDS

Diablo
Annihilus
Doctor Doom
Terrax
Mole Man
Diablo20% chance to Purify a Debuff.

Annihilus20% chance to Purify a Debuff.

Doctor Doom20% chance to Purify a Debuff.

Terrax20% chance to Purify a Debuff.

Mole ManWhile Frenzied, Mole Man’s attacks lower Defensive Ability Accuracy by 50% fighting against the #Fantastic Four.

Unique Synergy: Does not stack with duplicate synergies.

FAN CLUB

Captain Marvel
Ms. Marvel (Kamala Khan)
Captain MarvelFury Buffs in Binary Ignition have 10% increased potency.

Ms. Marvel (Kamala Khan)All melee attacks have 20% chance to Armor Break for each stack of active Fury reducing Armor Rating by +15%.

Unique Synergy: Does not stack with duplicate synergies.

FAMILY?

Stryfe
Cable
Cyclops (Blue Team)
Cyclops (New Xavier School)
Phoenix

All Champions gain +[4, 5, 6]% Health.

FAMILY REUNION

Black Widow (Deadly Origin)
Red Guardian
Black Widow (Deadly Origin)Black Widow starts the fight with her Passive Evade active until triggered.

Red GuardianWhile charging a Heavy Attack, become Passively Unstoppable for 0.6 seconds. Cooldown: 10 seconds.

Unique Synergy: Does not stack with duplicate synergies.

FAMILY FEUD

Red Goblin
Venom
Red GoblinLose 1 less Bloodlust when defeated.

VenomReduce the duration of Venom's Klyntar Buff by 30%.

Unique Synergy: Does not stack with duplicate Synergies.

FAMILIAR INSIGHT

Captain America
Iron Man (Infinity War)
Captain America (Infinity War)
Captain America (WWII)
Captain AmericaWeakness, Fatigue, Bleed, and Petrify Debuffs last 15% longer.

Iron Man (Infinity War)Blocking reduces 10% more damage.

Unique Synergy: Does not stack with duplicate synergies.