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DEATHWISH

Platinum Pool
Doctor Doom
Platinum Pool : Increase the chance to draw the Sumopool Card.

Solo: Only affects this Champion and does not stack.

Decimation

Scarlet Witch (Sigil)
Cyclops (New Xavier School)
Emma Frost
Storm
Wolverine
Scarlet Witch (Sigil) : Copied Buffs have 25% increased duration.

All Champions: Mutant Opponents have 30% reduced Ability Accuracy during either Champions Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.

DECIMATION

Sabretooth
Magneto
Magneto (House of X)
Scarlet Witch (Classic)
Sabretooth : Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto : Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto (House of X) : Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Scarlet Witch (Classic) : Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Unique Synergy: Does not stack with duplicate synergies.

DEFENDERS DESTROYER

Elektra
Kingpin
Iron Fist
Iron Fist (Immortal)
Luke Cage
Elektra : +25% Bleed Ability Accuracy & duration.

Kingpin : Enter the fight with 2 Rage.

Iron Fist : +25% Armor Break duration and Potency.

Iron Fist (Immortal) : +25% Armor Break duration and Potency.

Luke Cage : Up to +60% Attack Rating based on Physical Resistance.

Unique Synergy: Does not stack with duplicate synergies.

DEICIDE

Gorr
Thor
Thor (Ragnarok)
Thor (Jane Foster)
Gorr : Shadow Magic Buff duration increased by 2 second(s).

Solo Synergy: Only affects this Champion and does not stack.

DEMON HUNTER

Blade
Mephisto
Dormammu
Blade : Danger Sense bonuses expand to include all Mystic Champions. Danger Sense's Ability Accuracy reduction does not ignore the Immunities from Mystic Champions.

Mephisto : Opponent's Energy Resistance is reduced by -950.

Dormammu : Opponent's Energy Resistance is reduced by -950.

Unique Synergy: Does not stack with duplicate synergies.

Demonic Pact

Dormammu
Mephisto
Scarlet Witch (Sigil)
Dormammu : Imbued Attacks have 1250 increased Attack Rating.

Mephisto : While the Opponents Soul is Imprisoned, 100% chance to activate Aura of Incinerate when the Opponent fails to gain a Buff through Chance. Cooldown 1 second.

Scarlet Witch (Sigil) : Chaos Surge creates Regeneration instead of Prowess, granting 4% of missing health over 12 seconds. Prowess can no longer be copied, but Regeneration can.

Dimensional Beings: +15% increased Ability Power Rate.
Unique Synergy: Does not stack with duplicate Synergies.

DEMONS

Mephisto
Dormammu
Mephisto : +80% Energy Resistance while taking Damage over time.

Dormammu : +80% Energy Resistance while taking Damage over time.

Unique Synergy: Does not stack with duplicate synergies.

Did We Just Become Best Friends

Bullseye
Deadpool
Deadpool (X-Force)
Bullseye : Block Penetration increases by 5% for each personal Cruelty Passive.

Deadpool : Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Deadpool (X-Force) : Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Unique Synergy: Does not stack with duplicate synergies.

DIFFERENT BUT THE SAME

Omega Sentinel
Omega Red
Omega Sentinel : For each Armor Up consumed during a Special Attack, inflict an Armor Break Debuff reducing Armor Rating by 10% for the duration of that Special Attack.

Solo Synergy: Only affects this Champion and does not stack.

DIMENSIONAL BUDDIES

Purgatory
Dormammu
Magik
Mephisto
The Hood

#DimensionalBeings: Gain Bleed Immunity, 20% increased Ability Accuracy, and +900 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.

DINKY SHRINKS

Ant-Man
Psycho-Man
Wasp
Yellow Jacket
Ant-Man : Special Attack 1 inflicts the Opponent with 2 Stagger Debuffs for 12 second(s).

Psycho-Man : Heavy Attacks grant a non-stacking Armor Up Buff, increasing Armor Rating by +600 for 10 second(s).

Wasp : +1200 Block Proficiency.

Yellow Jacket : When the Opponent fills a Bar of Power, they gain a Power Sting Debuff for 8 seconds, dealing 30% of Yellowjacket's Attack as Direct Damage.

Unique Synergy: Does not stack with duplicate synergies.

DINNER PARTY

Kindred
Silk
Spider man (Miles Morales)
Spider-Man (Classic)
Kindred : +10% Degeneration effect potency

Solo Synergy: Only affects this Champion and does not stack.

Disco Inferno

Dazzler
Human Torch
Masacre
Omega Sentinel
Phoenix
Sunspot
Dazzler : Performing a Dazzling Dash inflicts an Incinerate Debuff dealing 20% of Attack as Energy Damage over 10 seconds.

Other Synergy Champions: Incinerate and Plasma Debuffs gain 15% duration.
Unique Synergy: Does not stack with duplicate synergies.

DISPLAY OF STRENGTH

Cull Obsidian
Ebony Maw
Thanos
Cull Obsidian : New Mission: Show your Might: Knockout a Champion while the Rout Buff is active. This mission can only be completed once each Quest.

Solo: Only affects this Champion and does not stack.

DO YOU EVEN LIFT?

Titania
Colossus
Drax
Hulk
Hyperion
Titania : Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Colossus : Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Drax : Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hulk : Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hyperion : Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

DOCTOR DESPOTS

Doctor Strange
Iron Man (Infamous)
Doctor Strange : Heavy Attacks refresh all existing Blessings, and all effects of Special 1 are increased by a flat 100% for each active Blessing.

Iron Man (Infamous) : Cowardice effects on the Opponent are 50% more potent.

Unique Synergy: Does not stack with duplicate synergies.

DOCTORS STRANGE

Sorcerer Supreme
Doctor Strange
Symbiote Supreme
Sorcerer Supreme : Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Doctor Strange : Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Symbiote Supreme : Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Unique Synergy: Does not stack with duplicate synergies.

DON'T CALL ME PRINCESS

America Chavez
Kate Bishop
America Chavez : Reduce the duration of the Opponent’s Indestructible and Regeneration Buffs by 40% for each unique Parallel Dimension.

Kate Bishop : The max stack limit of all Trick Arrows is increased by 1.

Unique Synergy: Does not stack with duplicate synergies.

DON'T MENTION PUNY BANNER!

Hulk (Ragnarok)
Hulk
Hulkbuster
Hulk (Ragnarok) : Gains up to +1000 Physical Resistance based on how high the Crowd Meter is.

Hulk : Immunity to Nullify, Fate Seal and Stagger.

Hulkbuster : Up to +1000 Armor Rating based on how low Hulkbuster’s current Health is.

Unique Synergy: Does not stack with duplicate Synergies.