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Ultimate Teammates

White Tiger
Iron Fist
Luke Cage
Nova
Spider-Man (Classic)

Synergy Champions: Gain +4% Perfect Block Chance for each unique Synergy Champion on the team. If all Synergy Champions are present, also gain +30% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Pitcher Perfect

Bullseye
Cyclops (New Xavier School)
Cyclops (Blue Team)
BullseyeIf an attack doesn’t Critically Hit a non-Mutant Opponent, gain a non-stacking 50% Fury Buff for 3 seconds. This Buff will not re-trigger while already active, and is not affected by Ability Accuracy reduction.

Cyclops (New Xavier School)Intercepting the Opponent with a Beam Attack grants a non-stacking 50% Fury Buff for 3 seconds.

Cyclops (Blue Team)Intercepting the Opponent with a Beam Attack grants a non-stacking 50% Fury Buff for 3 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Did We Just Become Best Friends

Bullseye
Deadpool
Deadpool (X-Force)
BullseyeBlock Penetration increases by 5% for each personal Cruelty Passive.

DeadpoolStart each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Deadpool (X-Force)Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Unique Synergy: Does not stack with duplicate synergies.

Black and White and Red all over

Bullseye
Daredevil (Classic)
Daredevil (Hell's Kitchen)
Elektra
BullseyeIf Daredevil or Daredevil (Hell’s Kitchen) are Knocked Out, start each fight with an indefinite 10% Cruelty Buff.

Daredevil (Classic)If Elektra is Knocked Out, start each fight with an indefinite 20% Fury Buff.

Daredevil (Hell's Kitchen)If Elektra is Knocked Out, start each fight with an indefinite 20% Fury Buff.

ElektraIf Bullseye is Knocked Out, start each fight with an indefinite 20% Precision Buff.

Unique Synergy: Does not stack with duplicate synergies.

Eye for an Eye

Bullseye
Hawkeye
Kate Bishop

Synergy Champions: Dialed In Passives increase the duration of their associated effects by an additional +3%.
Unique Synergy: Does not stack with duplicate synergies.

TWO SIDES OF THE COIN

Guillotine (Deathless)
Guillotine
Guillotine (Deathless)Souls last 30% longer and are paused during either Champion's Special Attacks.

GuillotineThe potency of healing from damage taken by the Opponent is increased by 66.6%.

Unique Synergy: Does not stack with duplicate synergies.

Deadless Enemies

Guillotine (Deathless)
Guillotine 2099
Guillotine
Morningstar
Purgatory

Synergy Champions: For each Synergy Champion present, gain 40 Critical Rating and 2% Ability Power Rate.
Unique Synergy: Does not stack with duplicate synergies.

Mutant Absorption

Onslaught
Professor X
Magneto
Magneto (House of X)
OnslaughtWhen defeating a Mutant Champion, Onslaught Passively Regenerates 15% of his missing Health.

Solo Synergy: Only affects this Champion and does not stack.

Close Enough

Onslaught
Cable
Stryfe
OnslaughtStriking an Opponent or their Block while they are Unstoppable consumes 3 personal Daunted effects and removes the Unstoppable. Cooldown: 20 seconds.

Solo Synergy: Only affects this Champion and does not stack.

Red Onslaught

Onslaught
Red Skull
OnslaughtAgainst Skill Champions, while attacking, Onslaught Passively Regenerates 85% of incoming Physical Damage.

Solo Synergy: Only affects this Champion and does not stack.

Final Boss

Onslaught
Apocalypse
OnslaughtWhen Onslaught’s Combo Meter passes a multiple of 20, gain a non-stacking Crush Charge.

Solo Synergy: Only affects this Champion and does not stack.

Takeover

Onslaught
Sentinel
OnslaughtGain +1075 Block Proficiency.

Solo Synergy: Only affects this Champion and does not stack.

Past and Future Self

Maestro
The Overseer
MaestroGain Neutronium 20% faster. During Superior Rage, Neutronium expires 20% slower.

The OverseerPersonal Special Concussion Debuffs gain +10% flat potency but their stack limit is reduced to 4.

Unique Synergy: Does not stack with duplicate synergies.

Big Bads

Maestro
Red Skull
Kang the Conqueror
Thanos

Synergy Champions: Gain +100 Armor Rating, +100 Critical Rating, +100 Critical Damage Rating, and +3% Perfect Block Chance, doubled when fighting the final node in a Quest.
Unique Synergy: Does not stack with duplicate synergies.

By your Powers Combined

Maestro
Captain America
Hulk
Iron Man
Ronan
MaestroGain +10% Fury potency for each other Synergy Champion on the team.

Solo Synergy: Only affects this Champion and does not stack.

What You Fear, You’ll Destroy

Chee'ilth
Abomination
Abomination (Immortal)
Red Hulk
The Overseer
Chee'ilthWhen struck while performing a Heavy Attack, become Passively Unstoppable for 3 seconds. Cooldown: 45 seconds. [Gamma]: Cooldown becomes 5 seconds.

Synergy Champions: Personal damaging effects gain 15% increased potency.
Unique Synergy: Does not stack with duplicate synergies.

What You Don’t Know, You’ll Fear

Chee'ilth
Absorbing Man
Hulk (Ragnarok)
Joe Fixit
Rhino
Chee'ilthWhen Blocking a Heavy Attack, become Passively Unstoppable for 3 seconds. Cooldown: 45 seconds. [Gamma]: Cooldown becomes 5 seconds.

Synergy Champions: +8% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

If You Don’t Talk, You Won’t Know Them

Chee'ilth
Hulk
Hulk (Immortal)
Sasquatch
She-Hulk
Chee'ilthSister Eagle grants 3 additional Cleanse Passives at the start of each fight. [Gamma]: Gain 8 Cleanse Passives instead.

Synergy Champions: +8% Health.
Unique Synergy: Does not stack with duplicate synergies.

First on the Scene

Chee'ilth

All Champions except Chee’ilth: Regeneration Buffs and Passives gain 5% increased potency.
Unique Synergy: Does not stack with duplicate synergies.

First

Kushala
Dani Moonstar
Chee'ilth
KushalaBlessings of Power reduce the Opponent’s Ability Power Rate by an additional -10% each.

Dani MoonstarThe first time each fight Dani would be struck, she gains a Combo Shield Passive for 5 seconds.

Chee'ilthChee’ilth has a 100% chance to block Unblockable Special Attacks while she has 8 or more personal Cleanse Passives.

Unique Synergy: Does not stack with duplicate synergies.