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ROTTED SOULS

Iron Man (Infamous)
Mephisto
Iron Man (Infamous)Whenever Infamous Iron Man is immune to an effect, he deals the Opponent a burst of Energy Damage equal to 200% of his Attack Rating. Each subsequent time this ability triggers, its potency is reduced by 20%.

MephistoDuration of Soul imprisonment is doubled.

Unique Synergy: Does not stack with duplicate synergies.

ROOMMATES

Spot
Mysterio
SpotGain 10% Rupture Debuff Potency.

MysterioGain 1 Chemical Gas when a hit Misses Mysterio. 10 second cooldown.

Unique Synergy: Does not stack with duplicate synergies.

ROMANCE - MOJO

Mojo
MojoGain +5% Power Gain.

Solo: Mojo only loves himself.
Unique Synergy: Does not stack with duplicate synergies.

ROMANCE

Domino
Colossus
Wolverine

All Teammates gain +[3, 4, 5]% Power Gain.

ROBOT UPRISING

Warlock
Ultron (Classic)
Ultron
Vision
Vision (Age of Ultron)

Whenever any teammate would receive a Debuff they are immune to, they gain a Fury Buff, increasing Attack Rating by 60% for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.

RIVAL METALLURGY

Shuri
Misty Knight

Synergy Members: Shock and Coldsnap effects gain +20% potency and are paused during the Opponent’s Special Attacks.
Unique Synergy: Does not stack with duplicate synergies.

RISE AGAINST THE CONTEST

Magneto (House of X)
Apocalypse
Professor X
Magneto (House of X)+5% Attack rating during the fight and Magneto’s Atonement Synergy gains +25% Potency.

ApocalypseHorsemen gain +30% Prowess Potency.

Professor XAll of Professor X's Prowess Buffs gain 20% Duration.

Unique Synergy: Does not stack with duplicate Synergies.

REVOLUTIONS NEED ARMS

Yellow Jacket
Killmonger
Magneto
Mole Man
Storm (Pyramid X)
Yellow JacketNuclear Core Starting Charge and Overheat Point are increased by +10.

Villain Champions: +5% Health Rating.
Unique Synergy: Does not stack with duplicate Synergies.

RESTORATION KIT

Nick Fury
Deadpool (X-Force)
Deadpool
Platinum Pool

All Champions except Nick: If Nick is alive, once per fight when a teammate is inflicted with a Bleed, Poison or Shock Debuff he will drop a Restoration Kit, Purifying the Debuff and Regenerating 10% of their max health over 3 seconds.
Unique Synergy: Does not stack with duplicate synergies.

RESPONSIBLE ADULTS

Wong
Shang Chi
WongSpecial Attack 1 grants an additional 10 Eldritch Energy.

Shang ChiSpecial Attack 3 Readys all Unreadied Wushu Strikes and triggers Guaranteed Crits for 8 second(s).

Unique Synergy: Does not stack with duplicate synergies.

RESISTANCE IS FUTILE

Nimrod
Omega Sentinel
Sentinel
NimrodUp to +25% Armor Rating based on missing Health.

Robots: If a Robot is defeated. They gain a Self-Repair Cross-Fight which gets consumed when they enter their next Fight, Regenerating 25% of their missing health over 20 seconds. This effect ends early if Stunned.
Unique Synergy: Does not stack with duplicate Synergies.

REMEMBERING BUDAPEST

Black Widow (Deadly Origin)
Hawkeye
Ronin
Black Widow (Deadly Origin)Reduce the potency of incoming Bleed Debuffs by 10%. Reduce the potency by an additional 10% if either Ronin or Hawkeye is Dead.

HawkeyeIncrease the duration of Bleed and Disorient Debuffs by 10%. Gain an additional 30% Duration if Black Widow (Deadly Origin) is Dead.

RoninIncrease the duration of Bleed and Disorient Debuffs by 10%. Gain an additional 30% Duration if Black Widow (Deadly Origin) is Dead.

Unique Synergy: Does not stack with duplicate synergies.

REDEMPTION

Magneto (House of X)
Colossus
Guardian
Magneto (House of X)Defeating #Villain Champions grants 1 Persistent Charge. +10% Attack while fighting #Villains.

ColossusOpponent’s Nullify & Stagger effects suffer -65% Ability Accuracy.

GuardianGain Force Field charges 3.5 seconds faster.

Unique Synergy: Does not stack with duplicate Synergies.

REMEMBER ME

Black Widow (Deadly Origin)
Taskmaster
Black Widow (Deadly Origin)Each time Black Widow strikes with Widow’s Insight active she gains 2% of a Bar of Power.

TaskmasterEach time he Exploits a Weakness, Taskmaster has a 30% chance to Inflict a Sabotage Debuff, reducing Defensive Ability Accuracy by 20% for 10 seconds and dealing 10% of Attack as direct Damage when Abilities fail to trigger.

Unique Synergy: Does not stack with duplicate synergies.

REAL LIVEWIRE

Shuri
Nebula

Synergy Members: For every 5 personal Shock effects removed by personal abilities, inflict an identical Shock effect.
Unique Synergy: Does not stack with duplicate synergies.

RAIN OF FIRE

Super-Skrull
Human Torch
Invisible Woman
Mister Fantastic
Thing

Other Synergy Members: The last hit of Special Attack 1 Incinerates the Opponent for 6 second(s).
This also inflicts Heal Block if all other Champions in this Synergy are present.
Unique Synergy: Does not stack with duplicate synergies.

RAGE ON

Mangog
Hulk (Immortal)
Kingpin
Wolverine (X 23)
MangogWhen becoming Enraged, inflict the Opponent with a 5 seconds Suppression Debuff reducing their Combat Power Rate by 30%.

Solo: Only affects this Champion and does not stack.

QUEENS OF SOULS

Purgatory
Hela
PurgatoryGaining Bloodthirst grants +1 additional Bloodthirst per captured Class Soul.

HelaGain an Unblockable Buff during Special Attack 1 and 2 while at 150 or more Spirits of the Dead.

Unique Synergy: Does not stack with duplicate synergies.

Q BRANCH

Shuri
Beast
Iron Man (Infamous)
Mister Fantastic

Synergy Members: Start each fight with an indefinite Failsafe Charge. When struck by a Special Attack 1 or 2, consume the Failsafe to gain an Indestructible Passive for the duration of the Special.
Unique Synergy: Does not stack with duplicate synergies.

QUEEN OF HEL

Hela
Angela

Champions have a 100% chance to instantly regain 20% of their HP just before they're knocked out. Each living teammate reduces this chance by 20%.