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Shuri
Nebula

Synergy Members: For every 5 personal Shock effects removed by personal abilities, inflict an identical Shock effect.
Unique Synergy: Does not stack with duplicate synergies.

RAIN OF FIRE

Super-Skrull
Human Torch
Invisible Woman
Mister Fantastic
Thing

Other Synergy Members: The last hit of Special Attack 1 Incinerates the Opponent for 6 second(s).
This also inflicts Heal Block if all other Champions in this Synergy are present.
Unique Synergy: Does not stack with duplicate synergies.

RAGE ON

Mangog
Hulk (Immortal)
Kingpin
Wolverine (X 23)
MangogWhen becoming Enraged, inflict the Opponent with a 5 seconds Suppression Debuff reducing their Combat Power Rate by 30%.

Solo: Only affects this Champion and does not stack.

QUEENS OF SOULS

Purgatory
Hela
PurgatoryGaining Bloodthirst grants +1 additional Bloodthirst per captured Class Soul.

HelaGain an Unblockable Buff during Special Attack 1 and 2 while at 150 or more Spirits of the Dead.

Unique Synergy: Does not stack with duplicate synergies.

Q BRANCH

Shuri
Beast
Iron Man (Infamous)
Mister Fantastic

Synergy Members: Start each fight with an indefinite Failsafe Charge. When struck by a Special Attack 1 or 2, consume the Failsafe to gain an Indestructible Passive for the duration of the Special.
Unique Synergy: Does not stack with duplicate synergies.

QUEEN OF HEL

Hela
Angela

Champions have a 100% chance to instantly regain 20% of their HP just before they're knocked out. Each living teammate reduces this chance by 20%.

PYRAMID X

Jabari Panther
Apocalypse
Archangel
Juggernaut
Storm

Synergy Members: Gain a Precision Buff during Special Attacks for each Damage over Time Debuff and Stagger Passive on the Opponent, each increasing Critical Rating by +375.
Unique Synergy: Does not stack with duplicate synergies.

PURE HATRED

Psycho-Man
Mangog
Psycho-ManThe Control Box is unable to cycle out of Hate mode and Opponents are 20% more likely to use a Heavy Attack. Personal Shock Debuff potency is increased by +60%. Personal Fury Buffs refresh when the Fourth Light Attack lands a hit or it strikes into a block.

MangogEach stack of Hatred increases Regeneration Rate by 1%.

Unique Synergy: Does not stack with duplicate synergies.

PUNY GOD

Hulk (Ragnarok)
Loki
Hulk (Ragnarok)+1000 Physical Resistance while Unstoppable.

LokiBasic Attacks against Loki have a 10% chance to miss, while his Opponent is under the effect of any Buff.

Unique Synergy: Does not stack with duplicate synergies.

PUNK'S PANACHE

Titania
Captain Marvel (Classic)
Storm
Yondu

Synergy Members: Special Attacks don't generate Power for the Opponent if Titania is alive, and gain +10% Attack Rating if Captain Marvel is alive, +750 Critical Rating if Storm is alive, and +400 Critical Damage Rating if Yondu is alive.
Unique Synergy: Does not stack with duplicate synergies.

Punishments of Infinite Variety

Cosmic Ghost Rider
Punisher 2099
Cosmic Ghost RiderThe first time your Opponent reaches Max Power each fight, drain 5% of their Power and trigger a Power Lock Debuff lasting 2 seconds.

Punisher 2099Heavy Attacks have a 100% chance to grant a Fury Buff increasing Attack Rating by 25% for 10 seconds.

Unique Synergy: Does not stack with duplicate synergies.

PUNCHING PURPLE PEOPLE

Jessica Jones
Dragon Man
Purgatory
Storm (Pyramid X)
Thanos
Baron Zemo
Jessica JonesStriking a Champion who has an active Unblockable, True Damage, or Prowess effect grants a Fury Passive, increasing Attack Rating by 30% for 8 seconds.

Synergy Members: Filling a Bar of Power randomly grants a dormant Unblockable, True Damage, or 40% Prowess Charge. Charges are removed and replaced with their corresponding Buffs during this Champion’s next Special Attack.
Unique Synergy: Does not stack with duplicate synergies.

PROFESSORS IN CRIME

Taskmaster
Crossbones
TaskmasterInstantly gain 5% of his Max Power each time he Exploits a Weakness.

CrossbonesGain 2 additional Fury Buff(s) when entering Overrun.

Unique Synergy: Does not stack with duplicate synergies.

PROBLEMS WITH CARTOONS

Scorpion
Spider-Ham
Scorpion25% chance to inflict Sting Debuffs on light attacks.

Spider-HamWhen triggering Porker Poppers 30% chance to inflict a Concussion Debuff, reducing Ability Accuracy by 40% for 10 second(s).

Unique Synergy: Does not stack with duplicate synergies.

Probably OP:

Longshot
Domino
LongshotPure of Heart lasts 4 seconds longer.

DominoIf an Opponent was not Struck over the Duration of a Stun, Domino gains 10% of a bar of Power.

Unique Synergy: Does not stack with duplicate Synergies.

PROBABILITY PALS

Black Cat
Domino
Longshot
Black CatBlack Cat starts the fight with 40 additional hits in her Combo Meter.

DominoWhenever an Opponent’s ability fails to trigger, Domino adds +1 Combo to her Combo Meter.

LongshotWhen Longshot gains Good Karma, he has a 39% chance to gain an additional 1 Good Karma.

Unique Synergy: Does not stack with duplicate synergies.

PRISONER

Terrax
Annihilus
Terrax+15% Attack Rating.

AnnihilusAll Fury Buffs last an additional 1 second(s).

Unique Synergy: Does not stack with duplicate synergies.

PRESSURE POINTS

Kraven
Tigra
KravenOn a Critical Hit, inflict a Fragility Debuff for 5 seconds. When attacking a Fragile Opponent, increase Critical Damage Rating by [200, 230] and decrease their Block Proficiency by 15%.

TigraWhile the Opponent is Neutralized Tigra gains [1500, 1710] Critical Rating.

Unique Synergy: Does not stack with duplicate synergies.

POWER OF MONEY

Yellow Jacket
Joe Fixit
Kingpin
Taskmaster
Yondu
Yellow JacketInflicting a Debuff grants +10 Core Charge. Cooldown: 10 seconds.

Villain Champions: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate Synergies.

POWER KIT

Nick Fury
Loki
Scarlet Witch (Classic)

All Champions except Nick: If Nick is alive, once per fight when a teammate is inflicted with an effect that would reduce or block their Power Bar he will drop a Power Kit, Removing the effect and granting 1 bar of power over 10 seconds.
Unique Synergy: Does not stack with duplicate synergies.