Abomination (Immortal), Abomination - Each time a Poison Debuff expires or is removed from the Opponent there is a 5% chance to inflict an Enervate Debuff for 3 seconds, preventing Power gained when struck.
Unique Synergy: Does not stack with duplicate synergies.

Nebula, Sentinel, Darkhawk, Warlock,Guillotine 2099 - gain 70% of a Bar of Power each time an immunity prevents a Bleed or Poison effect. This can't trigger more than once every 12 seconds.
Unique Synergy: Does not stack with duplicate synergies.

Science Champions: Increase the Duration and Ability Accuracy of any Exhaustion, Fatigue, Heal Block, Petrify, Slow, and Weakness Debuffs by 10%. Increased to up to 40% based on Sunspot's Signature Level.
Unique Synergy: Does not stack with duplicate Synergies.

Tony’s suit advances further, allowing him to ensure the second Superior Buff gained via Medium Attacks will be a Superior Regeneration with 10% increased potency.

Solo Synergy: Only affects this Champion and does not stack.

Second Medium attacks have a 25% chance to trigger Spider-Man 2099 Debuff Pausing ability.

Heavy Attack inflicts a Power Drain, removing 50% of the Opponent’s current power over 5 second(s). This effect has a 20 second(s) cooldown.

When granting a Buff on herself, gain 15% of a Bar of Power over 3 second(s).

On a Well Timed Block 33% chance to gain a Bulwark Passive, granting 700 Block Proficiency for 10 second(s).

Unique Synergy: Does not stack with duplicate synergies.

The final hit of Special Attack 2 has a 50% chance to inflict a Stun Debuff for 2 seconds.

The final 3 hits of Special Attack 2 inflict either Poison, Incinerate, or Bleed Debuffs based on the current Vishanti Blessing, each dealing 60% of Attack over 8 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Human Torch and Iceman - When the Opponent takes Energy damage, they take an additional burst of Energy damage equal to 15% of the original damage.
Unique Synergy: Does not stack with duplicate synergies.

Synergy Champions: Regen effects grant +15% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Spending Anti-Metal or Cryogenic Charges pauses active Equilibrium Buffs for 11 second(s).

While Valkyrie has an equal number of Pierce and Bulwark Buffs, she becomes Unstoppable while charging her Heavy Attack.

Unique Synergy: Does not stack with duplicate synergies.

Gaining Dark Energy has a 10% chance to trigger a Fury Buff, granting 20% Attack Rating for 9 seconds.

When inflicting Delirium there is a 50% chance to also inflict an Enervate Debuff for 2 seconds, preventing the Opponent from gaining Power when struck.

Heavy Attacks place an Energy Vulnerability Debuff on the Opponent, reducing Energy Resistance by 700 for 8 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Special 2 Stun effect is expanded to Special 1 and Special 3.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

When the Cookin' Meter hits 100, 75% chance to gain an Ice Armor Buff, granting +2000 Armor Rating and Stun Immunity for 20 seconds. Ice Armor is lost once it prevents a Stun effect.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Gain Cookin' Meter every 3 seconds instead of every 5.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Illogical DNA grants Immunity to Incinerate effects.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Gain +3% Perfect Block Chance for each Buff on Venompool. Max Bonus +21%.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Start the fight with 1 Blender Buff activated.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

+300 Critical Rating for each Unique Buff.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Spider-Nonsense resets to +3 more than it would normally.

Completing a Spider-Challenge grants a Fury Passive, granting +20% Attack Rating for 16.10 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Fate Seal Duration increased by 50%.

Maximum Eldritch Energy increased to 125.

Unique Synergy: Does not stack with duplicate synergies.

When the Cookin' Meter hits 100, 40% chance to gain a Regeneration Buff, recovering 5% of Max Health over 15 seconds.

Synergy Champions: +4% Health & Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.