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Double (Triple) Agent

Spider-Woman
Nick Fury
Super-Skrull
Spider-WomanWhen Immune to one of her own Fury Buffs, inflict 2 personal Power Stings. If the Signature Ability is active, trigger its chance to gain a Fury Passive. While in a fight, count as a #S.H.I.E.L.D agent.

Nick FuryStart with 6 Tactical Advantage Charges when fighting a #Villain.

Super-SkrullStart each fight with an Undermine Buff for 20 seconds, and his personal Undermine lasts 5 seconds longer.

Unique Synergy: Does not stack with duplicate synergies.

Strikeforce

Spider-Woman
Winter Soldier
Angela
Wiccan
Spider-WomanIncrease the potency of Fury effects by 20%.

Winter SoldierStart each fight with 5 indefinite Cleanse Passives.

AngelaOn the final hit of a Heavy Attack, gain a non-stacking 25% Aptitude Buff for 10 seconds.

WiccanSpell pause duration is increased by 3 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Spider Cop

Spider-Woman
Spider-Gwen
Spider-Man (Classic)
Spider man (Miles Morales)
Spider Man 2099

Synergy Champions: Gain +5% Combat Power Rate, or +10% against #Symbiote and #Sinister Six Champions.
Unique Synergy: Does not stack with duplicate synergies.

Hydra Rebel

Spider-Woman
Arnim Zola
Red Skull
Crossbones
Spider-WomanAgainst Mystic Champions, gaining a Buff inflicts a 50% Concussion Passive for 0.5 seconds which cannot affect Nodes. While in a fight, count as #Hydra and a #Villain instead of a #Hero.

Arnim ZolaThe final hit of Special Attack 1 inflicts a Root Debuff for 3 seconds.

Red SkullOn a Well-Timed Block, 25% chance to not lose an Armor Up Buff.

CrossbonesWhile Overrun is on cooldown, Intercepts trigger Crossbones’ Fury pause ability.

Unique Synergy: Does not stack with duplicate synergies.

…We Are Reborn

Phoenix
Jean Grey
PhoenixLight Attack 3 inflicts a personal Instant Incinerate.

All Champions gain 5% Regeneration effect potency.
Unique Synergy: Does not stack with duplicate synergies.

The Destiny Inside Me

Bastion
Storm
Beast
Cable
Nightcrawler
BastionFor each defeated Synergy Champion on the team, gain +6% Attack Rating.

Mutant Champions: For each Mutant Champion on the team, gain +4% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Players of the Game

Bastion
Peni Parker
BastionSpecial Attack Infection abilities trigger even if Infection is not active. This can only trigger 2 times per match.

Peni ParkerSpecial 3 sets the Sync-Shield’s strength to 200%.

Unique Synergy: Does not stack with duplicate synergies.

This is my Family

Bastion
Sentinel
Nimrod
Omega Sentinel
BastionPersonal Disintegration effects gain 20% increased duration.

SentinelWhile the Opponent is suffering from a personal Shock effect, ERADICATE Protocol expires 30% slower.

NimrodAt max Analysis Charges, personal non-Damaging Debuffs expire 50% slower during the Opponent’s Special Attacks.

Omega SentinelPersonal non-Damaging Debuff durations are increased by +2.5 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Need a Hand?

Bastion
Nightcrawler
Cable
BastionWhile Bastion’s personal Pursuit is active, whenever an Evade fails to activate, inflict 4 Techno-Mechanical Virus Charges and pause Pursuit for 1.2 seconds.

NightcrawlerMax stacks of Prowess increased by +5.

CablePersonal Regeneration Buff Ability Accuracy increased by +10% flat. When a personal Regeneration is activated, gain a non-stacking 20% Power Efficiency Passive for 14 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Sisters

Jean Grey
Storm
Jean GreyThe first hit of Jean’s Heavy Attack pauses her personal Daunted for 5 seconds.

StormActivating a Striker or Special Attack while charging or releasing a Heavy Attack pauses all Prowess effects on Storm for 10 seconds.

Unique Synergy: Does not stack with duplicate synergies.

The Fire Within

Jean Grey
Purgatory
Jean GreyCrossing a Bar of Power grants Jean a +750 Bulwark Passive for 10 seconds.

PurgatoryAt the start of Purgatory’s first fight in a quest, gain the Mutant Cross-Fight Class Soul.

Unique Synergy: Does not stack with duplicate synergies.

Mentor

Jean Grey
Professor X
Jean GreyPersonal Delirium effects gain a flat +20% potency.

Professor XHis personal Falter can trigger against Special Attacks while charging a Heavy Attack. When it does, the cooldown is increased by 15 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Birdman

Falcon (Joaquin Torres)
Vulture
Falcon (Joaquin Torres)Knocking down the Opponent deals 150% of Attack as a burst of Physical Damage.

VultureKnocking down the Opponent deals 150% of Attack as a burst of Physical Damage.

Unique Synergy: Does not stack with duplicate synergies.

Squawkman

Falcon (Joaquin Torres)
Patriot
Falcon (Joaquin Torres)When Falcon’s Signature Ability burst activates, gain [1] Velocity Charge. Cooldown: 3 seconds.

PatriotWhen a Miss effect is prevented, deal 20% of Attack as a burst of Physical Damage. Cooldown: 1 second.

Unique Synergy: Does not stack with duplicate synergies.

Creatures of Flight

Falcon (Joaquin Torres)
Sauron
Morbius
Falcon (Joaquin Torres)Dash Attacks pause personal Debilitate Debuffs for [4] seconds.

SauronPersonal bursts of Physical Damage gain [25%] increased potency.

MorbiusGlide’s Medium Attack inflicts 2 additional Bleed Debuffs.

Unique Synergy: Does not stack with duplicate synergies.

There goes my hero!

Falcon (Joaquin Torres)
Captain America (Sam Wilson)
Falcon
Falcon (Joaquin Torres)For each Velocity Charge gained throughout the fight, gain +1% Attack Rating and +50 Block Proficiency. Max: 50 Velocity Charges.

Captain America (Sam Wilson)Reduce Recon Scan’s cooldown by [25%].

FalconReduce Recon Scan’s cooldown by [25%].

Unique Synergy: Does not stack with duplicate synergies.

Geneticists

Arnim Zola
Mister Sinister
Arnim ZolaPersonal Disintegration Debuffs deal 20% more damage.

Mister SinisterPersonal Degeneration Debuffs deal 20% less damage but gain 50% increased duration.

Unique Synergy: Does not stack with duplicate synergies.

Glued to the Tube

Arnim Zola
Mojo
Arnim ZolaThe first time in each fight Zola is struck by a Heavy Attack, he gains a Brace Buff until the end of the attack. Brace causes Champions to be Passively Unstoppable against the final hit of incoming Special 1, Special 2, and Heavy Attacks.

MojoFor every million Followers, Passively Regenerate 10% of damage taken from Blocked hits. Max: 50%.

Unique Synergy: Does not stack with duplicate synergies.

Super Specimen

Arnim Zola
Captain America (Infinity War)
Arnim ZolaStart each fight with an indefinite +500 Armor Up Buff.

Captain America (Infinity War)Signature Ability Debuffs have a 100% chance to be inflicted an additional time, reduced by -25% flat for each instance of this Debuff already present.

Unique Synergy: Does not stack with duplicate synergies.

Zema & Zolo

Arnim Zola
Baron Zemo
Arnim ZolaWhen an Opponent is Immune to a Stun effect, gain 10 ESP Charges.

Baron ZemoIf Zemo runs out of Cleanses during an Opponent’s Special Attack, his Root is inflicted once the Special Attack ends.

Unique Synergy: Does not stack with duplicate synergies.