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Two More Shall Take Its Place

Arnim Zola
Red Skull
Punisher 2099
Crossbones
Taskmaster
Captain America
Captain AmericaWhile in a fight, Captain America counts as #Hydra and a #Villain instead of a #Hero.

#Hydra Champions: Start each fight with an indefinite Lying In Hate Passive, increasing Attack Rating by +10%. When struck by a Special Attack 1 or 2, Lying in Hate is consumed to grant an Indestructible Passive for the remainder of the Special Attack.
Unique Synergy: Does not stack with duplicate synergies.

Vibranium Club

Gentle
Captain America (Sam Wilson)
Captain America (Infinity War)
Misty Knight
GentleIncrease the Ability Accuracy of Muscle Mass by 25%.

Captain America (Sam Wilson)Increase the Ability Accuracy of personal Armor Ups by 25%.

Captain America (Infinity War)Increase the Ability Accuracy of personal Debuffs by 25%.

Misty KnightIncrease the Ability Accuracy of personal Purifies and Evades by 25%.

Massive Gains

Gentle
Mole Man
Galan
GentleGain +57 Block Rating per Muscle Mass.

Mole ManWhen activating Frenzy, gain a True Accuracy Buff for 2 seconds per Monster Mass, to a max of 14 seconds.

GalanReaching 315 Planetary Mass while the Harvest is not active grants a Heavy Attack Stun Charge. While this Charge is active, starting a Heavy Charge while the Opponent is within striking Distance inflicts a Stun Passive for 0.6 seconds and consumes the Charge.

Unique Synergy: Does not stack with duplicate synergies.

Wakanda Mutant

Gentle
Storm
Black Panther
GentleIncrease the potency of Reverbs by 20%.

StormWhen the Opponent Purifies a Debuff, gain 1 additional Prowess.

Black PantherIntercepts are Guaranteed Critical Hits.

Unique Synergy: Does not stack with duplicate synergies.

Guardian of Wakanda’s Throne

Okoye
Black Panther
Black Panther (Civil War)
Killmonger
Okoye+10% Attack Rating, doubled once the Opponent is brought below 50% Max Health.

Black PantherIf Okoye is alive, gain Block Proficiency equal to 25% of Critical Rating.

Black Panther (Civil War)If Okoye is alive, gain Block Proficiency equal to 25% of Critical Rating.

KillmongerIf Okoye is alive, gain Block Proficiency equal to 25% of Critical Rating.

Unique Synergy: Does not stack with duplicate synergies.

Weapon & Warfare Wisdom

Okoye
Chee'ilth
The Serpent
Adam Warlock
OkoyeOnce per fight when Okoye’s Block is broken by an Unblockable attack, inflict a Weakness Debuff reducing Attack Rating by 85% for 10 (15) seconds.

Synergy Champions: 15% increased Debuff duration.
Unique Synergy: Does not stack with duplicate synergies.

Protector of Crowns

Okoye
Valkyrie
Medusa
Heimdall

Synergy Champions: +3% Health and +3% Attack Rating. Once per fight, Evading an attack, Landing a Heavy Attack, or Knocking the Opponent down with a Special Attack grants +7% Attack Rating until the end of the fight.
Unique Synergy: Does not stack with duplicate synergies.

Midnight Angels

Okoye
Shuri
OkoyeIf Awakened, gain 15% increased Debuff duration. Otherwise, gain Level 1 of Okoye’s Signature Ability.

ShuriShock Debuffs gain 25% increased duration.

Unique Synergy: Does not stack with duplicate synergies.

Deathless Arbiter

She-Hulk (Deathless)
Thanos (Deathless)
She-Hulk (Deathless)Intercepting the Opponent inflicts a personal Trauma Debuff. Cooldown: 5 seconds.

Thanos (Deathless)Intercepting the Opponent inflicts an Instant Corrosion dealing 20% of Attack Rating.

Unique Synergy: Does not stack with duplicate synergies.

Deathless Processor

Vision (Deathless)
Thanos (Deathless)
Vision (Deathless)Upon triggering an Immunity, Burn 50% of a Bar of Power from the Opponent. If this reduces the Opponent’s Power below any full Bar, gain a Phase Charge. This ability has a 12 second cooldown.

Thanos (Deathless)Gain Immunity to Power Burn and Power Drain effects.

Unique Synergy: Does not stack with duplicate synergies.

Deathless Reaper

King Groot (Deathless)
Thanos (Deathless)
King Groot (Deathless)Gain an Undermine Buff during Special Attacks.

Thanos (Deathless)Personal Genesis Passives gain 30% increased duration.

Unique Synergy: Does not stack with duplicate synergies.

Deathless Harvester

Guillotine (Deathless)
Thanos (Deathless)
Guillotine (Deathless)The amount of Max Health required to gain a new Soul is decreased by 2%.

Thanos (Deathless)For each personal Debuff on the Opponent, gain +200 Critical Damage Rating.

Unique Synergy: Does not stack with duplicate synergies.

Umbral Vanguard

Thanos (Deathless)
Guillotine (Deathless)
King Groot (Deathless)
Vision (Deathless)
She-Hulk (Deathless)
Guillotine (Deathless)On activation, Special 1 inflicts a non-stacking 150% Neutralize Passive for 15 seconds.

King Groot (Deathless)When struck by an Unblockable attack, spend one Fury Buff to gain an Unstoppable Passive for 3 seconds.

Vision (Deathless)Personal Fury max stack increases by +6, and their pause is increased by +5 seconds.

She-Hulk (Deathless)Punishing the Opponent’s Special or Heavy Attacks grants a Grit Buff for 10 seconds.

Unique Synergy: Does not stack with duplicate synergies.
Synergy Champions: In the Necropolis, gain +50 Vengeance Charges. If all Champions are present:

Iron Heel

Thanos (Deathless)
She-Hulk (Deathless)
She-Hulk (Deathless)Gain Immunity to Rupture effects, and the Ability Accuracy of She-Hulk’s personal Debuffs and the Parry Mastery can only be reduced by Skill Champions.

Unique Synergy: Does not stack with duplicate synergies.

Twisted Insight

Thanos (Deathless)
Vision (Deathless)
Vision (Deathless)Gain Immunity to Reverse Controls. Additionally, after the Opponent activates a Special Attack, Vision Power Burns 1 Bar of their Power. If this Burns at least 50% of a Bar of Power, gain 1 personal Phase Charge.

Unique Synergy: Does not stack with duplicate synergies.

Molten Fist

Thanos (Deathless)
King Groot (Deathless)
King Groot (Deathless)Malice’s bonus to Fury potency can continue to build to a maximum of 200% after 200 seconds.

Unique Synergy: Does not stack with duplicate synergies.

Reaping Blade

Thanos (Deathless)
Guillotine (Deathless)
Guillotine (Deathless)Souls expire up to 70% more slowly based on how much more Max Health the Opponent has than Guillotine. Additionally, the first hit of Special 1 Nullifies 1 Buff.

Unique Synergy: Does not stack with duplicate synergies.

Found Technology

Isophyne
Ægon
ÆgonThe final hit of Heavy Attack Purifies 2 Debuffs.

#Eidols: Whenever a personal Immunity triggers, gain a +8% Fury Passive for 12 seconds. Max stacks: 3.
Unique Synergy: Does not stack with duplicate synergies.

Get out of my Dimension!

Isophyne
Howard The Duck
Gwenpool
Spot
IsophyneActivating Special 1 at 3 Bars of Power inflicts 3 Energy Vulnerabilities.

Howard The DuckParry Mastery Stun duration gains +0.4 seconds.

GwenpoolWhenever a personal effect is refreshed via Bleed consumption, gain an indefinite +15% Fury Passive. Max: 5.

SpotUntouchable expires 50% slower during the Opponent’s Special Attacks.

Unique Synergy: Does not stack with duplicate synergies.

Those that are truly confident

Isophyne
Gladiator
IsophyneIsophyne starts with 4 Ego and their Max Ego is increased by +2.

GladiatorHeavy Attacks grant +1 additional Confidence Buff. Furthermore, while the Opponent is suffering from Intimidate, Dashing forward inflicts a Root Passive for the duration of the Dash. Cooldown: 8 seconds.

Unique Synergy: Does not stack with duplicate synergies.