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Dust
Sandman
Terrax
Magneto
Karnak
Magneto (House of X)
Benders of Earth
Synergy Champions: +4% Attack Rating for each unique Synergy Champion on the team.
Jessica Jones
Iron Fist
Iron Fist (Immortal)
BEST MAN
Jessica Jones: Increased chance of throwing the Fire Hydrant with Special Attack 1. Also, whenever the Opponent suffers a Debuff, 40% chance to inflict a Stagger Passive for 4 seconds.
Iron Fist, Iron Fist (Immortal) - Well-Timed Blocks inflict a Stagger Debuff for 2 seconds. Perfectly-Timed Blocks inflict Fateseal instead.
Unique Synergy: Does not stack with duplicate synergies.
The Leader
Hulk
Hulk (Immortal)
Abomination
Abomination (Immortal)
Bestowed by the One Below All
#Gamma Champions: Gain +5% increased Attack Rating for each #Gamma Champion on the team.
Domino
M.O.D.O.K.
Taskmaster
BETTER LUCK NEXT TIME
Domino: If Domino never hit with a Special Attack while both Lucky and Unlucky were active, then she has +20% chance to activate them during her next fight.
M.O.D.O.K. or Taskmaster: Bleed abilities last 2 second(s) longer.
Unique Synergy: Does not stack with duplicate synergies.
Apocalypse
Stryfe
BIG BAD DAD
Apocalypse: Activating Special Attack 1 or 2 increases the potency of personal burst damage by +25%, this can stack up to +300% max.

Stryfe: The final hit of Special Attack 2 pauses all Shock effects on the Opponent for 4 seconds. If this champion is a Horseman of Apocalypse become Passively Unblockable as long as 20 Telepathic Charges are active.
Unique Synergy: Does not stack with duplicate synergies.
Maestro
Red Skull
Kang the Conqueror
Thanos
Big Bads
Synergy Champions: Gain +100 Armor Rating, +100 Critical Rating, +100 Critical Damage Rating, and +3% Perfect Block Chance, doubled when fighting the final node in a Quest.
Unique Synergy: Does not stack with duplicate synergies.
Kraven
Beast
Dragon Man
Sasquatch
BIG GAME
Synergy Champions: Stunning a Stun Immune Champion will instead inflict a non-stacking Concussion Debuff, reducing Ability Accuracy by 60% for 5 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Elsa Bloodstone
Tigra
BIG GAME HUNTERS
Elsa Bloodstone: Enhanced Ammunition Debuffs last 4.0 seconds longer. Additionally, when fighting on the last node in a quest, Opponents cannot activate True Strike or True Accuracy abilities.

Tigra: When fighting #Large and #XL Champions, increase the duration of Rupture effects by 25%.
Unique Synergy: Does not stack with duplicate Synergies.
Werewolf By Night
Man-Thing
Big Game Monsters
Werewolf By Night: Chilling Howl inflicts a 5% Physical Vulnerability Debuff for 25 seconds. Max stacks: 3.
Solo Synergy: Only affects this Champion and does not stack.
Ant-Man
Doctor Octopus
BIOCHEMISTRY
Ant-Man: When causing a Hit to Glance, reflect 40% of Physical Damage done, by attacks that make Contact.

Doctor Octopus: Start with 40 Chemistry Research.
Unique Synergy: Does not stack with duplicate synergies.
Darkhawk
Sauron
Captain America (Sam Wilson)
Falcon
BIRD TELEPATHY
Darkhawk: Each hit of Special 1 has a 10% chance to refresh the current active mode.

Sauron: When performing a Well-Timed Block, 30% chance gain a Physical Resistance Buff. If there are more Physical Resistance Buffs than Energy Resistance, gain Energy Resistance instead. These Buffs increase their corresponding Resistance by +[520, 537] and last for 10 second(s).
Captain America (Sam Wilson), Falcon: Opponent Combat Power Rate is decreased by 40% while Lock-On is on a Cooldown.
Unique Synergy: Does not stack with duplicate synergies.
Falcon (Joaquin Torres)
Vulture
Birdman
Falcon (Joaquin Torres): Knocking down the Opponent deals 150% of Attack as a burst of Physical Damage.

Vulture: Knocking down the Opponent deals 150% of Attack as a burst of Physical Damage.
Unique Synergy: Does not stack with duplicate synergies.
Darkhawk
Vulture
Falcon
Hawkeye
BIRDS OF PREY
Darkhawk, Vulture, Falcon, Hawkeye: + 5% Critical Rating and Damaging Debuffs are 40% stronger.
Unique Synergy: Does not stack with duplicate synergies.
Professor X
BIRTHRIGHT
All Mutants and X-Men except Professor X: +25% Special Attack Damage for each Cerebro Charge. Max 100%.
Unique Synergy: Does not stack with duplicate synergies.
Bullseye
Daredevil (Classic)
Daredevil (Hell's Kitchen)
Elektra
Black and White and Red all over
Bullseye: If Daredevil or Daredevil (Hell’s Kitchen) are Knocked Out, start each fight with an indefinite 10% Cruelty Buff.

Daredevil (Classic): If Elektra is Knocked Out, start each fight with an indefinite 20% Fury Buff.

Daredevil (Hell's Kitchen): If Elektra is Knocked Out, start each fight with an indefinite 20% Fury Buff.

Elektra: If Bullseye is Knocked Out, start each fight with an indefinite 20% Precision Buff.
Unique Synergy: Does not stack with duplicate synergies.
Gorr
Hercules
Ikaris
Sersi
BLOOD AND GORR
Gorr: The recovery reduction from Poison effects on Gorr is 50% less effective.
Solo Synergy: Only affects this Champion and does not stack.
Mister Sinister
Cyclops (Blue Team)
Cyclops (New Xavier School)
Phoenix
BLOOD LINES
Mister Sinister, Cyclops (Both), Phoenix: Special Attacks have +20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion, and Auto Block.
Unique Synergy: Does not stack with duplicate synergies.
Cyclops (Blue Team)
Gladiator
Blue Boy Scouts
Cyclops (Blue Team): For the first 1 second of each fight, Cyclops has a 100% chance to Evade and Counter-Attack dealing 200% of Attack as a burst of Energy Damage on hit. Additionally, he Evades the first time he would be struck during a Medium Attack.

Gladiator: Increase Confidence Limit by +3, and each hit of Special Attack 2 gains +30% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Archangel
Nebula
The Champion
BLUETIFUL PEOPLE
All Champions gain +[250, 325, 400] Block Penetration
Baron Zemo
Deadpool
Mantis
Spider-Man (Symbiote)
Star-Lord
BOOGIE BOOGIE UPRISING
Synergy Members: Dodging back and holding Block activates a 1.2 second timer. Releasing Block just as the timer expires grants a Jiggy With It Buff for 20 seconds, increasing Critical Rating by +150 and granting an Unstoppable Passive while Dodging backwards or Dashing forwards.
Unique Synergy: Does not stack with duplicate synergies.