Tempered in Battle

Star-Lord (Stellar Forged), Okoye, Daredevil (Hell's Kitchen), Cull Obsidian

Synergy Champions: While a Combo Shield is active, gain +8% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

Reshaped in the Stars

Star-Lord (Stellar Forged), Patriot, Dani Moonstar, Star-Lord

Synergy Champions: Once per fight, activating a Special Attack grants a Combo Shield Passive for 20 seconds. This will not activate while another Combo Shield is active.
Unique Synergy: Does not stack with duplicate synergies.

Neighborhood Rivals

Spider-Slayer (J. Jonah Jameson), Spider-Man (Classic), Spider Man (Stark Enhanced), Spider-Man (Stealth-Suit), Spider-Man (Symbiote), Spider-Man (Supreme)

All Champions gain +115 Critical Damage Rating.
Unique Synergy: Does not stack with duplicate synergies.

I Disagree with the Implication

Spider-Slayer (J. Jonah Jameson), Mole Man, Peni Parker, Howard The Duck

Synergy Champions: Start each fight with a 5% Safeguard Buff for 2 seconds that begins paused until it prevents damage, and is removed when the Opponent activates a Special Attack 3. When it ends for any reason, it returns after 45 seconds.
Unique Synergy: Does not stack with duplicate synergies.

Mustache Panache

Spider-Slayer (J. Jonah Jameson), The Serpent, The Leader, Wong, Doctor Strange

Synergy Champions: Intercepting the Opponent grants a non-stacking +15% Confidence Passive for 10 seconds.
Unique Synergy: Does not stack with duplicate synergies.

I Hired You

Spider-Slayer (J. Jonah Jameson), Scorpion, Venom

Unique Synergy: Does not stack with duplicate synergies.

Understanding Camera Value

Spider-Slayer (J. Jonah Jameson), Mojo

Unique Synergy: Does not stack with duplicate synergies.

Possible Futures

Doctor Strange, Iron Man (Infinity War), Spider Man (Stark Enhanced), Star-Lord, Mantis, Drax

Synergy Champions: There is a 1 in 14,000,605 chance to also start with an indefinite +1000% Fury Buff.
Unique Synergy: Does not stack with duplicate synergies.

Hand to Hand

Doctor Strange, Cyclops (Blue Team)

Unique Synergy: Does not stack with duplicate synergies.

Aggressive Negotiations

Doctor Strange, Dormammu

Unique Synergy: Does not stack with duplicate synergies.

The Void’s Resistance

Wolverine (X 23), Blade, Elektra, Gambit, Human Torch

Synergy Champions: Gain the bonuses of all present Synergy Champions if Human Torch is dead.
Unique Synergy: Does not stack with duplicate synergies.

With Your Heart in Your Hand

Wolverine (X 23), Wolverine

Unique Synergy: Does not stack with duplicate synergies.

A Good Lie

Punisher, Franken-Castle

Unique Synergy: Does not stack with duplicate synergies.

The Founder’s Military Might

Isophyne, Lumatrix, Solvarch, Imperiosa

Solo: Only affects this Champion and does not stack.

Cosmic Forces of The Contest

Imperiosa, King Groot, King Groot (Deathless), Venompool, Venom The Duck, Galan

Unique Synergy: Does not stack with duplicate synergies.

Many-Armed Menaces

Imperiosa, Doctor Octopus, Spiral

Unique Synergy: Does not stack with duplicate synergies.

Hive Minds Think Alike

Imperiosa, Ant-Man (Future), Ant-Man, Knull, Shathra

Unique Synergy: Does not stack with duplicate synergies.

Combined Genius of the Founders

Imperiosa, Isophyne, Lumatrix, Solvarch

Solo: Only affects this Champion and does not stack.

Chai Time

Spider-Man (Pavitr Prabhakar), Doctor Strange, Nico Minoru, Doctor Voodoo, Sersi, Scarlet Witch (Classic)

Synergy Champions: At the start of each fight, rapidly gain 50% of a Bar of Power.
Unique Synergy: Does not stack with duplicate synergies.

Rescue Mission: Distraction

Spider-Man (Pavitr Prabhakar), Spider-Ham, Spider-Punk

#Spider-Verse Heroes: +3% Health.
Unique Synergy: Does not stack with duplicate synergies.