TWO SIDES OF THE COIN
Guillotine (Deathless): Souls last 30% longer and are paused during either Champion's Special Attacks.
Guillotine: The potency of healing from damage taken by the Opponent is increased by 66.6%.
Unique Synergy: Does not stack with duplicate synergies.
Ultimate Teammates
Synergy Champions: Gain +4% Perfect Block Chance for each unique Synergy Champion on the team. If all Synergy Champions are present, also gain +30% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
UNACCEPTABULL
Rintrah: Inflict 4 Rupture Debuffs dealing 15% Attack Rating as Physical Damage over 15 second(s) on last hit of Special 1.
M.O.D.O.K.: On landing a Critical Hit, if both a personal Incinerate and Bleed on Opponent, pause them for 6 second(s).
Unique Synergy: Does not stack with duplicate synergies.
UNCANNY AVENGERS
Havok: Well Timed Blocks grant +1 Plasma Charge.
Captain America: Passively increases Attack by 20% of Base Attack when Striking a Debuffed Opponent.
Wasp: When Wasp charges a Heavy Attack while hitting with a Basic Attack Combo, she gains a Passive Fury Effect increasing her Attack by 50% of her Base Attack for 3 seconds.
Unique Synergy: Does not stack with duplicate synergies.
UNCHAINED
Morningstar: +50% Ability Power Rate while below 1 Bar of Power.
Purgatory: Gain a Soul Shard every 25 second(s).
Unique Synergy: Does not stack with duplicate synergies.
UNDER THE WEATHER
Storm (Pyramid X): Alternate Tempests activated by Storm's Special 3 last 8 seconds longer.
Storm: Gain Immunity to Incinerate and Coldsnap effects. Each time an Immunity prevents one of these effects, gain 2 Prowess Buff(s).
Unique Synergy: Does not stack with duplicate Synergies.
UNDERSTANDING EVIL
All Non-Villian Champions, gain 10% Attack Rating, 5% Physical Resistance, 5% Energy Resistance vs. Villains.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
UNENDING AMBITION
Diablo: Personal Poison Debuffs become Passive and gain +10% Potency.
Kingpin: Gain 1 Rage each time the opponent Nullifies a Buff.
Loki: +35% Curse Debuff duration.
Red Skull: 35% Shock Debuff Potency.
Unique Synergy: Does not stack with duplicate synergies.
United By Chance
Werewolf By Night: Start each fight with a 10% Vicious Passive for 30 seconds.
Morbius: Start each fight with a 10% Vicious Passive for 30 seconds.
Ghost Rider: Start each fight with a 10% Vicious Passive for 30 seconds.
Elsa Bloodstone: Start each fight with a 10% Vicious Passive for 30 seconds.
Man-Thing: Start each fight with a 10% Vicious Passive for 30 seconds.
Punisher: Gain this synergy’s bonus after taking a Lethal Blow during the Quest.
Legion of Monsters Champions (Morbius, Ghost Rider, Elsa Bloodstone, Man-Thing): Start each fight with a 10% Vicious Passive for 30 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
UNLIKELY COMBINATION
Ant-Man: Increase the Potency of Poisons by 20%.
Ronin: Gain +25% Block Proficiency in Guard Stance.
Unique Synergy: Does not stack with duplicate synergies.
UNMERCIFUL PUNISHMENT
Proxima Midnight: When True Accuracy is active, her Attack Rating is increased by 15%.
Nebula: Starts the fight with 10 Electroshock Charges.
Unique Synergy: Does not stack with duplicate Synergies.
UNREQUITED ROMANCE
Sersi: Start the fight with an indefinite Armor Up increasing Armor Rating by [30, 60, 100].
Solo Synergy: Only affects this Champion and does not stack.
UNTAMED FORCE
Sabretooth: 20% chance for his low-kick first Medium Attack to be Unblockable. Additionally, If the opponent activates an unstoppable effect as a result of this attack, it expires instantly.
Old Man Logan: +120% Regeneration Rate when hitting opponents.
Unique Synergy: Does not stack with duplicate synergies.
USAPHO
Synergy Members: Gain +10% Health and +10% Shock and Bleed potency.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
UTSHABA
Synergy Members: Start each fight with 10 indefinite Precision Passives. These don't count as Precisions and are consumed by Light and Medium hits to become Guaranteed Critical Hits.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
VESSELS OF DARKNESS
Knull: When the Opponent is immune to an effect, Knull gains a Fury Buff, increasing Attack Rating by 35% for 16 seconds. Max 1 stack(s).
Solo: Only affects this Champion and does not stack.
VICIOUS KITTY
Kitty Pryde: While 10+ Prowess are active, become Passively Unblockable while Phased.
Tigra: Neutralize effects last +35% longer.
Unique Synergy: Does not stack with duplicate synergies.
VILLAINS ACROSS THE COSMOS
Red Goblin: If this Champion is a Herald and below 41% health, enter Frenzy indefinitely. This is removed if Red Goblin goes above 41% health.
Venom The Duck: If this Champion is a Herald, ending a Combo with a Light Attack will remove all active Symbiote Buffs and increase Aberration by 50%. This ability only activates while 1 Buff is active.
Unique Synergy: Does not stack with duplicate synergies.
VVVVVV
Synergy Champions: Personal Buffs and Debuffs gain +10% potency.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
WAKANDA LEADERSHIP
Black Panther (Civil War): Well Timed Blocks provides a +30% Fury Buff for 15 seconds.
Killmonger: Starts the fight with 3 of his Indestructible and Counterpunch Charges.
Unique Synergy: Does not stack with duplicate Synergies.