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Scarlet Witch (Sigil)
Vision
Vision (Age of Ultron)
Till Infinity Do Us Part:
Scarlet Witch (Sigil): When Chaos Surge activates, 8% chance to gain an Aptitude Buff increasing Fury, Precision, and Armor Up Buffs by 30% for 18 seconds.

Vision: Landing a Heavy Attack on an Opponent suffering Heal Block grants a non-stacking Fury, increasing Attack Rating by 1000 for 15 seconds.

Vision (Age of Ultron): Landing a Heavy Attack on an Opponent suffering Heal Block grants a non-stacking Fury, increasing Attack Rating by 1000 for 15 seconds.
Unique Synergy: Does not stack with duplicate Synergies.
Anti-Venom
Doctor Octopus
Spider Man 2099
TIME TRAVELERS
Anti-Venom: For the first 10 second(s) of the fight the Opponent is immune to Buffs.

Doctor Octopus: When dealing damage per Breakthrough removed on a Heavy Attack, 25% chance per Breakthrough to inflict another burst of damage dealing Attack Rating in damage.

Spider Man 2099: On the start of the fight, inflict a Wither Debuff on the Opponent with a potency of 125% for 15 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Mordo
Doctor Voodoo
Sorcerer Supreme
Wong
TOO MANY SORCERERS...
Mordo: While fighting Mystic Champions, Mordo is Immune to Nullify and Fate Seal.
Synergy Champions: +6% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Morbius
Werewolf By Night
Elsa Bloodstone
Man-Thing
Ghost Rider
Punisher
Tormented Souls
Morbius: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.

Werewolf By Night: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.

Elsa Bloodstone: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.

Man-Thing: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.

Ghost Rider: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.
Legion of Monsters Champions: At the start of each fight, inflict a 35% Torment Passive for 30 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Nova
Annihilus
TOTAL ANNIHILATION
Nova: Gain +40% Perfect Block chance when triggering Auto-Block.

Annihilus: +65% Physical Resistance while Unstoppable.
Unique Synergy: Does not stack with duplicate synergies.
The Champion
Luke Cage
TOUGH BRAWLERS
The Champion: The Champion is Unstoppable when using a Light and Medium Attack.

Luke Cage: +35% chance to inflict Debuffs as long as Luke Cage never dashes back in a fight.
Unique Synergy: Does not stack with duplicate Synergies.
Baron Zemo
Captain America (Sam Wilson)
Falcon
Winter Soldier
TOUR GUIDE
Baron Zemo: Gain +500 Armor Rating and +500 Critical Damage Rating.

Captain America (Sam Wilson): Gain +25% Debuff duration and +500 Critical Damage Rating.

Falcon: Gain +25% Debuff duration and +500 Critical Damage Rating.

Winter Soldier: Gain +25% Debuff duration and +500 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.
Toad
Scarlet Witch (Classic)
Scarlet Witch (Sigil)
TOXIC LOVE
Toad: +15% Combat Power Rate while Paralytic Secretion is active.
Solo Synergy: Only affects this Champion and does not stack.
Jabari Panther
Black Panther
Black Panther (Civil War)
Killmonger
TRIBAL WARFARE
Jabari Panther: Gain an additional Cleanse Passive whenever one would be gained.

Black Panther: Critical Hits have an 80% chance to inflict a Bleed Debuff, dealing 50% of their Attack in damage over 4 second(s).

Black Panther (Civil War): Critical Hits have an 80% chance to inflict a Bleed Debuff, dealing 50% of their Attack in damage over 4 second(s).

Killmonger: Well-Timed Blocks grant a non-stacking Precision Buff for 4 second(s), increasing Critical Rating by +700.
Unique Synergy: Does not stack with duplicate synergies.
Vox
Knull
TRIPLE EDGE
Synergy Champions: Lose an additional 5% Health from the Double Edge Mastery, but it grants an additional +10% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Wolverine (Weapon X)
Platinum Pool
Kang the Conqueror
Thanos
TROPHY CASE
Wolverine (Weapon X): Start the fight with 5 Rage charges.

Platinum Pool: Start the fight with a Fury Buff, granting 50% of your Base Attack for 15 Seconds.

Kang the Conqueror: Start the fight with a Fury Buff, granting 50% of your Base Attack for 15 Seconds.

Thanos: Start the fight with a Fury Buff, granting 50% of your Base Attack for 15 Seconds.
Unique Synergy: Does not stack with duplicate synergies.
Lady Deathstrike
Old Man Logan
Wolverine
Wolverine (Weapon X)
TRUE HATRED
Lady Deathstrike: When defeating #X-Men, gain a Cross-Fight Fury Buff, increasing Attack Rating by 20%. The Fury Buff potency increases by 200% when defeating any Wolverine.

Old Man Logan: Personal Fury Buffs last 50% longer, and all Fury Buffs are paused during his or the Opponent’s Specials.

Wolverine: When any Bleed Debuff is Purified, inflict a Passive Bleed with 70% of the damage and same duration.

Wolverine (Weapon X): When any Bleed Debuff is Purified, inflict a Passive Bleed with 70% of the damage and same duration.
Unique Synergy: Does not stack with duplicate synergies.
Hulkling
Wiccan
TRUE LOVE
Hulkling: Hulkling is Stun Immune while he has at least 3 Pierce Buffs.
Unique Synergy: Does not stack with duplicate synergies.
Northstar
Sasquatch
Guardian
True North
Northstar: While Speed Burst is ready to be activated, Northstar’s Combat Power Rate is increased by 15%.

Sasquatch: When immune to a Stun or Frostbite effect, or when inflicted with Coldsnap Debuff, pause Wrath of Tanaraq for 5 seconds.

Guardian: A Perfect Block briefly briefly pauses any Force Field charges that are expiring.
Unique Synergy: Does not stack with duplicate synergies.
Guardian
TRUE NORTHERN DEFENSE
All Champions except Guardian: +[500, 750, 1000, 1250] Block Proficiency.
Unique Synergy: Does not stack with duplicate synergies.
Toad
Magneto
TRULY DEVOTED
Toad: While Paralytic Secretion is active, gain an Unstoppable Buff for 5 seconds when charging a Heavy Attack. Cooldown 12 seconds.
Solo Synergy: Only affects this Champion and does not stack.
Iron Man (Infamous)
Human Torch
Mister Fantastic
Thing
TRUST ISSUES
Iron Man (Infamous): Gains +4900 Critical Rating while the Opponent has 2 or more Bars of Power.

Human Torch: Chance to Incinerate when Struck increased by a flat 100%.

Mister Fantastic: Imprison the Opponent’s Soul at the start of the fight, reducing their chance to activate Buffs by 100% for 15 seconds.

Thing: When Rock Stacks are removed, Thing gains an extra Fury Passive.
Unique Synergy: Does not stack with duplicate synergies.
Human Torch
Thing
TURN UP THE HEAT
Human Torch: Human Torch starts the fight with 2 Smoulder Passives, and his Temperature increases faster while charging a Heavy Attack.
Unique Synergy: Does not stack with duplicate synergies.
Diablo
Dormammu
Mangog
Symbiote Supreme
TWISTED ARCANISTS
Diablo: Philosopher’s Mix is Paused during Diablo’s Special Attacks.

Dormammu: After using an Imbued attack, gain 40 Dark Energy.

Mangog: While Enraged, gain +10% Attack Rating.

Symbiote Supreme: +1% Attack Rating for each Stagger on the opponent.
Unique Synergy: Does not stack with duplicate synergies.
Count Nefaria
Iron Man
Two Sides of a Coin
Count Nefaria: Whenever an Energy Build Up is inflicted, also inflict a 15% Decelerate Debuff lasting 18 seconds.

Iron Man: Whenever a Prowess is Invalidated, gain an Armor Up Buff.
Unique Synergy: Does not stack with duplicate synergies.