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Dust
Jubilee
The Shallow Twins
Dust: Whenever the Opponent activates a Purify, there is a 35% chance to inflict 1 Sand Passive.

Jubilee: When Jubilee’s Opponent Purifies a Debuff, pause the current Fireworks Surge for 3.5 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Man (Supreme)
Sorcerer Supreme
Symbiote Supreme
THE SUPREMES
Spider-Man (Supreme): Granting Spider-Seal Buffs to an Opponent that has no Buff or only Spider-Seal Buffs, inflicts a burst of 10% of Attack as Energy Damage.

Sorcerer Supreme: Special Attacks inflict an Energy Vulnerability Debuff, reducing Energy Resistance by -[1130, 1200] for 7.5 second(s).

Symbiote Supreme: Each time Stagger expires without nullifying a Buff, Symbiote Supreme gains 15 Genetic Potential.
Unique Synergy: Does not stack with duplicate synergies.
Shathra
Wasp
Yellow Jacket
The True Queen of the Hive
Shathra: Power Steal is replaced with a Power Gain, granting 160% of a Bar of Power per second.

Wasp: If the Opponent throws a Special Attack while Wasp’s personal Power Sting is active it will trigger Wasp’s Petrify. However, the Petrify when this occurs is capped at 200% potency.

Yellow Jacket: When the Opponent activates a Special Attack while personal Power Stings are active, gain 8 Nuclear Core Charges for each Power Sting removed.
Unique Synergy: Does not stack with duplicate synergies.
Vox
Thor
Thor (Jane Foster)
THE VILLAIN’S WEAKNESS
Vox: Attacking and Defending Vox: While fighting against Synergy Champions, receive +10% damage from hits involving hammers.
Other Synergy Champions: Attacks involving hammers have +10% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Shang Chi
Spider-Man (Classic)
THE WAY OF THE SPIDER
Shang Chi: Critical Hits bypass +20% of Armor and Resistances.

Spider-Man (Classic): Spider-Man can use Perfect-Timing while performing a Well-Timed Block or Dodging an attack to inflict a Physical Vulnerability Debuff reducing the Opponent’s Physical Resistance by 1400 for 30 seconds. Max 3 stack(s).
Unique Synergy: Does not stack with duplicate synergies.
Absorbing Man
Thor (Jane Foster)
Thor
THE WORTHY
Absorbing Man: The second Medium Attack inflicts an Armor Break Debuff, reducing Armor by 500 for 9 seconds. Max stacks: 5

Thor (Jane Foster): When facing Cosmic champions, The Mighty Thor inflicts Degeneration effects instead of personal Shocks, which count as Shocks for her abilities.

Thor: Thor’s Heavy attack inflicts an Armor Break Debuff, reducing Armor by 1800 for 4.5 seconds. Max stacks: 2
Unique Synergy: Does not stack with duplicate synergies.
Psycho-Man
Deadpool (X-Force)
Deadpool
Man-Thing
THERE GOES THE MULTIVERSE
Psycho-Man: Power Lock and Heal Block effects last 15% longer.

Deadpool (X-Force): Heavy Attacks inflict a non-stacking Armor Break Debuff, reducing Armor Rating by -700 for 10 second(s). Reverberate this!

Deadpool: Heavy Attacks inflict a non-stacking Armor Break Debuff, reducing Armor Rating by -700 for 10 second(s). Reverberate this!

Man-Thing: Gain up to 25% Perfect Block Chance based on Agitation.
Unique Synergy: Does not stack with duplicate synergies.
Man-Thing
Thing
THINGS
Man-Thing: Well Timed Blocks grant a Fury Buff increasing its Attack by 25% of its Base Attack for 1.5 seconds. This Fury doesn’t stack.

Thing: Thing’s Rock Stacks last Indefinitely up to 20.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Punk
Green Goblin
Red Goblin
Iron Patriot
This ain’t MAX pal!!
Spider-Punk: Personal Rupture Debuffs expire 10% slower. This becomes 20% slower against #Symbiotes.

Green Goblin: Whenever a Bag of Tricks effect fails due to chance, gain a Tricky Passive, increasing the Ability Accuracy of Bag of Tricks effects by 5% flat for 18 seconds. Max: 5. Tricky Passives have no effect on Super Bombs.

Red Goblin: When the Opponent’s Miss or Auto-block fails due to a reason other than chance while True Sense is active, gain a +30% Fury Buff for 10 seconds. Max: 2.

Iron Patriot: Personal Armor Break Debuffs have their Ability Accuracy increased by a flat amount to a total of 100%.
Unique Synergy: Does not stack with duplicate synergies.
Mantis
Psycho-Man
THIS ONE ALSO HAS MIXED EMOTIONS!
Mantis: Whenever Mantis inflicts a Mixed Emotion Passive, there is a 25% chance to inflict another.

Psycho-Man: Whenever Psychoman cycles his Control Box Mode, he gains 20% of a bar of Power over 1 second.
Unique Synergy: Does not stack with duplicate synergies.
Mantis
Gamora
Star-Lord
THIS ONE CAN SENSE THAT IT'S COMPLICATED
Mantis: The duration of personal Infuriate and Intimidate Debuffs are increased by 2 seconds.

Gamora: While Gamora has at least 6 personal Buffs active, her Special 2 becomes Unblockable.

Star-Lord: Elemental Guns are no longer random, effects can be cycled by double tapping Block. Effects are cycled: Fire, Air, Water, Earth.
Unique Synergy: Does not stack with duplicate synergies.
Mantis
Dormammu
Loki
Thanos
THIS ONE HAS ENEMIES
All Champions gain +[85, 115, 155] Critical Rating
Mantis
Silver Surfer
Vision
THIS ONE HAS FOUND ROMANCE
All Champions gain +[3, 4, 5]% Combat Power Rate.
Mantis
Rocket Raccoon
THIS ONE THINKS VIOLENCE IS NOT THE SOLUTION
Mantis: While at least 1 personal Cruelty Buff is active, gain a Precision Passive, increasing Critical Rating by 350.

Rocket Raccoon: Inflicting Power Drains with Special 1 now consumes 12 Scrap Metal instead of 15.
Unique Synergy: Does not stack with duplicate synergies.
Mantis
Drax
THIS ONE WON'T LET ANYTHING GO OVER YOUR HEAD!
Mantis: Mantis' Sleep inflicted by charging Heavy Attack has its duration increased by 0.5 seconds flat.

Drax: Drax can now Parry non-contact hits.
Unique Synergy: Does not stack with duplicate synergies.
Beta Ray Bill
Thor (Ragnarok)
Thor (Jane Foster)
Thors
Beta Ray Bill: The final hit of Special Attack 1 has a 33% chance to inflict a Stun Debuff for 3 seconds.

Thor (Ragnarok): Start each fight with a Thunder God’s Wrath Passive for 10 seconds.

Thor (Jane Foster): If the Opponent is not Shocked, Basic Attacks have a 10% chance to inflict a Shock Debuff, dealing 85% of Attack as Energy Damage over 4 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Kitty Pryde
Emma Frost
THROUGH THICK AND THIN
Kitty Pryde: Become Immune to reverse controls, and each time this immunity is triggered gain +1 personal Prowess. Cooldown 0.8 seconds.

Emma Frost: Gain +20% Attack Rating in diamond form and gain +20% Combat Power Rate in telepathic form.
Unique Synergy: Does not stack with duplicate synergies.
Taskmaster
Winter Soldier
THUNDERBOLTS
Taskmaster: Current Exploit Weakness target Attack has a 20% chance to become Unblockable.

Winter Soldier: Wintersoldier’s EMP Upgrade gains a flat +5% chance to trigger.
Unique Synergy: Does not stack with duplicate synergies.
Luke Cage
Red Hulk
Agent Venom
Elektra
Iron Patriot
Juggernaut
THUNDERBOLTS
All Champions take [5, 10, 15]% less Special Damage
Namor
Moon Knight
TIDE TO GO
Namor: Under a Full or New Moon, attacking or being attacked by Bleeding Opponents grants 5% of a bar of Power with each Strike. As the Moon waxes and wanes, Attack Rating is increased by +15%.

Moon Knight: Under a Full or New Moon, Combat Power Rate is increased by 10%. As the Moon waxes and wanes, Bleed and Fury potency is increased by 15%.
Unique Synergy: Does not stack with duplicate synergies.