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Mephisto
Morningstar
SOUL SEEKER
Mephisto: +1 Soul at the beginning of the fight.

Morningstar: Starts the fight with 1 Bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
The Overseer
Silver Surfer
SPACE SURFERS
The Overseer: The Energize Buff from his Special 2 also grants 450 Critical Rating.

Silver Surfer: Gain Precision Buff on Special 2, increasing Critical Rating by 450 for 12 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Proxima Midnight
Corvus Glaive
SPECIAL ASSIST
Proxima Midnight: Ultimate Mission’s Combo Meter requirement goes down to 75 hits.
Unique Synergy: Does not stack with duplicate Synergies.
Spider-Woman
Spider-Gwen
Spider-Man (Classic)
Spider man (Miles Morales)
Spider Man 2099
Spider Cop
Synergy Champions: Gain +5% Combat Power Rate, or +10% against #Symbiote and #Sinister Six Champions.
Unique Synergy: Does not stack with duplicate synergies.
Silk
Spider-Man (Classic)
SPIDER DYAD
Silk: Special Attack 2 inflicts stacks of Webbing. Webbing falls off slowly as the Opponent attacks and moves. For each stack of Webbing, personal bursts of damage gain 5% potency. Max stacks: 10.

Spider-Man (Classic): The first time in each fight Spider-Man would be struck by a Special Attack, he gains a 100% chance to Evade the rest of the Special Attack.
Unique Synergy: Does not stack with duplicate synergies.
Storm (Pyramid X)
Spider-Gwen
Spider-Man (Classic)
Spider man (Miles Morales)
SPIDER GUILD
Synergy Champions: Evade Ability Accuracy is increased by 30% and after activating Evade, inflict Stun for 2 seconds. Both of these effects enter cooldown for 12 seconds after this Stun is activated.
Unique Synergy: Does not stack with duplicate Synergies.
Spider-Punk
Ms. Marvel (Kamala Khan)
Ironheart
Spider-Gwen
Spider-Ham
Peni Parker
Spider-Band Members
Synergy Champions: Synergy Champions: +4% Attack Rating for each unique Synergy Champion on the team.
Unique Synergy: Does not stack with duplicate synergies.
Peni Parker
Spider-Gwen
Spider-Ham
Spider man (Miles Morales)
SPIDER-GEDDON
Peni Parker: Start the fight with 4 Spider-Sense charges.

Spider-Gwen: Start the fight with 4 Spider-Sense charges.

Spider-Ham: Start the fight with 4 Spider-Nonsense.

Spider man (Miles Morales): Each Spider-Sense charge grants +4% Attack Rating as well as +4% personal Debuff duration and Ability Accuracy.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Man (Stealth-Suit)
Spider man (Miles Morales)
Spider-Man (Symbiote)
SPIDER-MEN IN BLACK
Spider-Man (Stealth-Suit): +100% Evade Ability Accuracy against Unblockable attacks while the Opponent has a Fragility Debuff.

Spider man (Miles Morales): Special Attack 2 inflicts Power Sting for 8 seconds, dealing 100% of Attack as Direct Damage when the Opponent activates a Special Attack. Evade does not trigger while Blocking.

Spider-Man (Symbiote): Heavy Attack inflicts a Fragility Debuff for 9 second(s). Evade does not trigger while Blocking.
Unique Synergy: Does not stack with duplicate synergies.
Spider man (Miles Morales)
Mister Negative
Mysterio
Red Goblin
Vulture
SPIDER-SENSES....TINGLING
Spider man (Miles Morales): Spider-Sense Charges grant +5% Attack Rating each.
All Synergy Champions: +7% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Spider Man 2099
Spider-Gwen
Spider-Ham
Spider-Man (Classic)
Spider man (Miles Morales)
SPIDER-VERSE VETERANS
Spider Man 2099: Gain 100% chance to Evade the first time he is struck in a fight.

Spider-Gwen: Gain an Unstoppable Passive for 1 second(s) after an Evade triggers. This effect has a 9 second(s) cooldown.

Spider-Ham: Gain an Unstoppable Passive for 1 second(s) after an Evade triggers. This effect has a 9 second(s) cooldown.

Spider-Man (Classic): Gain an Unstoppable Passive for 1 second(s) after an Evade triggers. This effect has a 9 second(s) cooldown.

Spider man (Miles Morales): Gain an Unstoppable Passive for 1 second(s) after an Evade triggers. This effect has a 9 second(s) cooldown.
Unique Synergy: Does not stack with duplicate synergies.
Black Widow (Claire Voyant)
Black Widow
SPIDER’S BITE
Black Widow (Claire Voyant): While Death Touch is active, Claire's Attacks reduce the Opponent’s chance of triggering their abilities by 50%.

Black Widow: Activating a Special Attack grants a Fury Buff increasing Attack Rating by 20% for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Blade
Ghost Rider
SPIRIT OF JUSTICE
Blade: Danger Sense bonuses expand to include all Villain Champions. However, its Ability Accuracy reduction does not bypass Villains' immunities to Ability Accuracy reduction.

Ghost Rider: +50% chance to place a Judgment.
Unique Synergy: Does not stack with duplicate synergies.
Wiccan
Scarlet Witch (Classic)
Scarlet Witch (Sigil)
Vision (Age of Ultron)
Vision
SPIRITUAL PARENTS
Wiccan: When a Buff fails to trigger due Reduced Ability Accuracy, Wiccan gains 2% of his Max Power.

Scarlet Witch (Classic): Critical Damage Rating is increased by [666, 700, 750] while launching Special Attack 1 or 2.

Scarlet Witch (Sigil): Regain 50% of the Instabilities removed when Degeneration expires.

Vision (Age of Ultron): Intercepting the Opponent inflicts a Passive Power Burn, burning 10% of the current Power.

Vision: Intercepting the Opponent inflicts a Passive Power Burn, burning 10% of the current Power.
Unique Synergy: Does not stack with duplicate synergies.
QuickSilver
Wiccan
SPIRITUAL UNCLE
QuickSilver: Gain 8.3% Degeneration Resistance for every 100 Momentum Charges.

Wiccan: Gaining a Bar of Power grants a Fury Buff, increasing Attack Rating by 20% for 10 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Green Goblin
Iron Patriot
SPLIT PERSONALITY
Green Goblin: Super Bomb Ability Accuracy +20%.

Iron Patriot: Arc Overload Potency +20%.
Unique Synergy: Does not stack with duplicate synergies.
Prowler
Spider-Punk
Splitting Heads
Prowler: Can activate a Pre-Fight Ability granting Immunity to Reverse Controls, but controls are inverted for the whole fight.

Spider-Punk: Whenever a Mystic Opponent gains a non-Instant Power Gain effect, they also turn up the gain on Spider-Punk’s amp and are inflicted with a personal Rupture Debuff.
Unique Synergy: Does not stack with duplicate synergies.
Falcon (Joaquin Torres)
Patriot
Squawkman
Falcon (Joaquin Torres): When Falcon’s Signature Ability burst activates, gain [1] Velocity Charge. Cooldown: 3 seconds.

Patriot: When a Miss effect is prevented, deal 20% of Attack as a burst of Physical Damage. Cooldown: 1 second.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Man (Stealth-Suit)
Iron Man (Infinity War)
STARK INTERNSHIP
Spider-Man (Stealth-Suit): Slow Opponents also have the Ability Accuracy of Shock and Incinerate effects reduced by 100%.

Iron Man (Infinity War): The duration of Incinerate and Plasma effects is increased by 50%.
Unique Synergy: Does not stack with duplicate synergies.
America Chavez
Annihilus
STAY POSITIVE
America Chavez: Each Stack of Negative Zone generates 1.2% of a bar of Power every second.

Annihilus: While Annihilus has an Unstoppable Buff he receives 50% less hit damage.
Unique Synergy: Does not stack with duplicate Synergies.