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Kushala
Doctor Strange
Sorcerer Supreme
Wong
Doctor Voodoo
Shadows on the Road Ahead
Synergy Champions: Activating a Special Attack 3 grants a non-stacking 10% Amplify Passive for 15 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Kushala
Ghost Rider
Cosmic Ghost Rider
Shadows on the Road Behind
Synergy Champions: Damaging Effects gain 10% increased potency.
Unique Synergy: Does not stack with duplicate synergies.
Kitty Pryde
Wolverine
SHADOWY HISTORY
Kitty Pryde: When Phase expires after causing Miss, there is a 30% chance to consume no Prowess.

Wolverine: Landing a Heavy Attack converts all Regeneration Buffs into Fury Buffs, each increasing Attack Rating by 10% for 12 seconds. Max stacks 4.
Unique Synergy: Does not stack with duplicate synergies.
Carnage
Venom
SHARED GENETIC MEMORY
Venom and Carnage gain +1 to their maximum number of Genetic Memory or Hyper Mutation Buffs.
Mister Fantastic
Angela
Groot
Masacre
Night Thrasher
SHARED KNOWLEDGE - ASTRONOMY
Cosmic and Skill Champion's Basic Hits pause one of each Buff on them for 0.2 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Mister Fantastic
Doctor Strange
Loki
Psylocke
Storm
SHARED KNOWLEDGE - GENETICS
Mutant and Mystic Champions regain 5% of the Power spent on any Special Attack, for each unique Special Attack they’ve used in the fight.
Unique Synergy: Does not stack with duplicate synergies.
Mister Fantastic
Doctor Octopus
Sentry
She-Hulk
Vulture
SHARED KNOWLEDGE - ROBOTICS
Tech and Science Champion's Debuffs also apply an indefinite Power Sting, dealing Direct Damage equal to 60% of their Attack Rating when the Opponent activates a Special Attack. The Power Sting stacks up to 3 times.
Unique Synergy: Does not stack with duplicate synergies.
The Overseer
Captain America
Captain America (Infinity War)
Captain America (WWII)
SHIELD BUDDIES
The Overseer: 15% chance that a Block is a Perfect Block, reducing all damage to 0.

Captain America: Intercepting the Opponent grants a non-Stacking Passive Fury, granting 50% Attack Rating for 7 second(s).

Captain America (Infinity War): Intercepting the Opponent grants a non-Stacking Passive Fury, granting 50% Attack Rating for 7 second(s).

Captain America (WWII): Intercepting the Opponent grants a non-Stacking Passive Fury, granting 50% Attack Rating for 7 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Attuma
Man-Thing
Toad
SHINING, SHIMMERING, SPLENDOR
Attuma: Start the fight with a dormant Hydration charge that, while active, grants a 50% chance to gain up to 10 stacks of Hydration on a Well-Timed Block. When Hydration is gained this way, the charge is consumed and is reapplied when Attuma gains Hydration from another source.

Man-Thing: The delay before Empathetic Agitation begins to fall off is doubled.

Toad: Landing a Heavy Attack refreshes all Poison Debuffs on the Opponent.
Unique Synergy: Does not stack with duplicate synergies.
Nebula
Black Widow (Deadly Origin)
Electro
Guardian
Storm
SHOCK RECURSION
Nebula: Gaining an Amp Charge Pauses all Shock Debuffs on the opponent for 0.2 seconds.
Solo: Only affects this Champion and does not stack.
Prowler
Spider-Man (Classic)
Showing the Light
Prowler: If the Opponent is not Faltered, Prowler has a 20% chance to Evade Basic Attacks while not Blocking.

Spider-Man (Classic): For each stack of Webbing on the Opponent, Special Attack 2 deals 10% of Attack Rating as a burst of Physical Damage.
Unique Synergy: Does not stack with duplicate synergies.
Gamora
Nebula
SIBLING RIVALRY
Gamora: Robot opponents suffer -10% Ability Accuracy and -2% Attack Rating for each personal Buff on Gamora.

Nebula: The first Special 1 each fight is a guaranteed Critical Hit. The same is true for the first Special 2.
All Synergy Champions: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Cassie Lang
QuickSilver
America Chavez
Viv Vision
SICK KICKS
Synergy Champions: All attacks involving shoes have their Attack Rating increased by 5%.
M.O.D.O.K.
Ultron (Classic)
Ultron
SINGULARITY
M.O.D.O.K.: Guaranteed Critical Hit occurs in 5 hits instead of 7.

Ultron (Classic): +200 Critical Damage Rating & +10% Perfect Block Chance.

Ultron: Triggering Function (Critical) also triggers Function (Damage).
Unique Synergy: Does not stack with duplicate synergies.
Kindred
Mysterio
Vulture
Scorpion
Doctor Octopus
Kraven
SINISTER MANIPULATOR
Synergy Members: +15% Attack Rating against #Spider-Verse Heroes.
Kraven
Doctor Octopus
Electro
Green Goblin
Rhino
Vulture
SINISTER SIX
Synergy Champions: When fighting #Heroes Combat Power Rate is increased by 25%.
Unique Synergy: Does not stack with duplicate synergies.
Sandman
Iron Patriot
Mysterio
Red Goblin
Scorpion
Shocker
SINISTER SUBSTITUTES
Synergy Champions: When fighting #Heroes Combat Power Rate is increased by 10%.
Unique Synergy: Does not stack with duplicate synergies.
Absorbing Man
Daredevil (Hell's Kitchen)
SINS OF THE FATHER
Absorbing Man: While at or below 15 Combo Meter, gain 1000 Block Proficiency, and while above, gain 1000 Critical Rating.

Daredevil (Hell's Kitchen): Personal Buffs last for an additional 7 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Enchantress
Lady Deathstrike
Psylocke
Sisters in Hood
Enchantress: New Evocation Spell: Poison Spray: ↓ , ↓ , ↑. Inflicts three Poison Debuffs.

Lady Deathstrike: Once per fight, while Ferocity is active, it does not unpause when Blocking an attack.

Psylocke: When consuming a Psi-Charge, 50% chance for it to be refunded.
Unique Synergy: Does not stack with duplicate synergies.
Domino
Deadpool
SIX PACK
Domino: +10% damage against Champions that aren’t female or robots.

Deadpool: Special 1 has a 50% chance to Stun Champions that aren’t female or robots for 2 second(s).
Unique Synergy: Does not stack with duplicate synergies.