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Hela
Angela
QUEEN OF HEL
Champions have a 100% chance to instantly regain 20% of their HP just before they're knocked out. Each living teammate reduces this chance by 20%.
Purgatory
Hela
QUEENS OF SOULS
Purgatory: Gaining Bloodthirst grants +1 additional Bloodthirst per captured Class Soul.

Hela: Gain an Unblockable Buff during Special Attack 1 and 2 while at 150 or more Spirits of the Dead.
Unique Synergy: Does not stack with duplicate synergies.
Mangog
Hulk (Immortal)
Kingpin
Wolverine (X 23)
RAGE ON
Mangog: When becoming Enraged, inflict the Opponent with a 5 seconds Suppression Debuff reducing their Combat Power Rate by 30%.
Solo: Only affects this Champion and does not stack.
Super-Skrull
Human Torch
Invisible Woman
Mister Fantastic
Thing
RAIN OF FIRE
Other Synergy Members: The last hit of Special Attack 1 Incinerates the Opponent for 6 second(s).
This also inflicts Heal Block if all other Champions in this Synergy are present.
Unique Synergy: Does not stack with duplicate synergies.
Spiral
Apocalypse
Cable
Stryfe
Re: The Apocalypse
Synergy Champions: The duration of personal Damaging effects is increased by 2 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Shuri
Nebula
REAL LIVEWIRE
Synergy Members: For every 5 personal Shock effects removed by personal abilities, inflict an identical Shock effect.
Unique Synergy: Does not stack with duplicate synergies.
Thanos (Deathless)
Guillotine (Deathless)
Reaping Blade
Guillotine (Deathless): Souls expire up to 70% more slowly based on how much more Max Health the Opponent has than Guillotine. Additionally, the first hit of Special 1 Nullifies 1 Buff.
Unique Synergy: Does not stack with duplicate synergies.
Onslaught
Red Skull
Red Onslaught
Onslaught: Against Skill Champions, while attacking, Onslaught Passively Regenerates 85% of incoming Physical Damage.
Solo Synergy: Only affects this Champion and does not stack.
Magneto (House of X)
Colossus
Guardian
REDEMPTION
Magneto (House of X): Defeating #Villain Champions grants 1 Persistent Charge. +10% Attack while fighting #Villains.

Colossus: Opponent’s Nullify & Stagger effects suffer -65% Ability Accuracy.

Guardian: Gain Force Field charges 3.5 seconds faster.
Unique Synergy: Does not stack with duplicate Synergies.
Black Widow (Deadly Origin)
Taskmaster
REMEMBER ME
Black Widow (Deadly Origin): Each time Black Widow strikes with Widow’s Insight active she gains 2% of a Bar of Power.

Taskmaster: Each time he Exploits a Weakness, Taskmaster has a 30% chance to Inflict a Sabotage Debuff, reducing Defensive Ability Accuracy by 20% for 10 seconds and dealing 10% of Attack as direct Damage when Abilities fail to trigger.
Unique Synergy: Does not stack with duplicate synergies.
Black Widow (Deadly Origin)
Hawkeye
Ronin
REMEMBERING BUDAPEST
Black Widow (Deadly Origin): Reduce the potency of incoming Bleed Debuffs by 10%. Reduce the potency by an additional 10% if either Ronin or Hawkeye is Dead.

Hawkeye: Increase the duration of Bleed and Disorient Debuffs by 10%. Gain an additional 30% Duration if Black Widow (Deadly Origin) is Dead.

Ronin: Increase the duration of Bleed and Disorient Debuffs by 10%. Gain an additional 30% Duration if Black Widow (Deadly Origin) is Dead.
Unique Synergy: Does not stack with duplicate synergies.
Nimrod
Omega Sentinel
Sentinel
RESISTANCE IS FUTILE
Nimrod: Up to +25% Armor Rating based on missing Health.
Robots: If a Robot is defeated. They gain a Self-Repair Cross-Fight which gets consumed when they enter their next Fight, Regenerating 25% of their missing health over 20 seconds. This effect ends early if Stunned.
Unique Synergy: Does not stack with duplicate Synergies.
Wong
Shang Chi
RESPONSIBLE ADULTS
Wong: Special Attack 1 grants an additional 10 Eldritch Energy.

Shang Chi: Special Attack 3 Readys all Unreadied Wushu Strikes and triggers Guaranteed Crits for 8 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Nick Fury
Deadpool (X-Force)
Deadpool
Platinum Pool
RESTORATION KIT
All Champions except Nick: If Nick is alive, once per fight when a teammate is inflicted with a Bleed, Poison or Shock Debuff he will drop a Restoration Kit, Purifying the Debuff and Regenerating 10% of their max health over 3 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Kindred
Mephisto
REVENANT BIRTH
Kindred: Activating Dread Aura grants an Unblockable Passive for 3 seconds. Cooldown: 20 seconds.
Solo Synergy: Only affects this Champion and does not stack.
Negasonic Teenage Warhead
Doctor Strange
Human Torch
Moon Knight
Phoenix
Revivified Support Group
Negasonic Teenage Warhead: While below 5% Health, the chance to Evade Medium and Light Attacks with Precognition becomes 100% until an Evade activates.
Synergy Champions: +10% Health.
Unique Synergy: Does not stack with duplicate synergies.
Yellow Jacket
Killmonger
Magneto
Mole Man
Storm (Pyramid X)
REVOLUTIONS NEED ARMS
Yellow Jacket: Nuclear Core Starting Charge and Overheat Point are increased by +10.
Villain Champions: +5% Health Rating.
Unique Synergy: Does not stack with duplicate Synergies.
Magneto (House of X)
Apocalypse
Professor X
RISE AGAINST THE CONTEST
Magneto (House of X): +5% Attack rating during the fight and Magneto’s Atonement Synergy gains +25% Potency.

Apocalypse: Horsemen gain +30% Prowess Potency.

Professor X: All of Professor X's Prowess Buffs gain 20% Duration.
Unique Synergy: Does not stack with duplicate Synergies.
Shuri
Misty Knight
RIVAL METALLURGY
Synergy Members: Shock and Coldsnap effects gain +20% potency and are paused during the Opponent’s Special Attacks.
Unique Synergy: Does not stack with duplicate synergies.
Warlock
Ultron (Classic)
Ultron
Vision
Vision (Age of Ultron)
ROBOT UPRISING
Whenever any teammate would receive a Debuff they are immune to, they gain a Fury Buff, increasing Attack Rating by 60% for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.