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Absorbing Man
Titania
ROGUE'S ROMANCE
Absorbing Man: Medium and Heavy Attacks gain 600 Critical Damage Rating.

Titania: Gain Immunity to Bleed effects.
Unique Synergy: Does not stack with duplicate synergies.
Domino
Colossus
Wolverine
ROMANCE
All Teammates gain +[3, 4, 5]% Power Gain.
Mojo
ROMANCE - MOJO
Mojo: Gain +5% Power Gain.
Solo: Mojo only loves himself.
Unique Synergy: Does not stack with duplicate synergies.
Dust
Wolverine (X 23)
Roommates
Dust: Striking an Unstoppable Opponent while Sandstorm is active grants Dust a personal Prowess Passive.

Wolverine (X 23): Start each fight with a Disguised Charge. When struck by an attack that would deal more than 5% of Wolverine’s Max Health, consume the Charge to lower the damage to 0. This ability does not work against Special Attack 3.
Unique Synergy: Does not stack with duplicate synergies.
Spot
Mysterio
ROOMMATES
Spot: Gain 10% Rupture Debuff Potency.

Mysterio: Gain 1 Chemical Gas when a hit Misses Mysterio. 10 second cooldown.
Unique Synergy: Does not stack with duplicate synergies.
Iron Man (Infamous)
Mephisto
ROTTED SOULS
Iron Man (Infamous): Whenever Infamous Iron Man is immune to an effect, he deals the Opponent a burst of Energy Damage equal to 200% of his Attack Rating. Each subsequent time this ability triggers, its potency is reduced by 20%.

Mephisto: Duration of Soul imprisonment is doubled.
Unique Synergy: Does not stack with duplicate synergies.
Black Panther
Storm
ROYALS
Black Panther: Gain a 1 second Unblockable Passive when activating a Special Attack during Panther’s Might.

Storm: Each Shock Debuff on the opponent grants +20% Special Attack Damage, Max Potency at 5 Shocks.
Unique Synergy: Does not stack with duplicate synergies.
Daredevil (Hell's Kitchen)
Daredevil (Classic)
Ronan
She-Hulk
RULE OF LAW
Daredevil (Hell's Kitchen): Special Attacks have a 20% chance to inflict a Stun Debuff. Duration is 1.25 seconds per level of Special Attack used.
Synergy Champions: +10% Attack Rating.
Unique Synergy: Does not stack with duplicate Synergies.
Havok
Cyclops (Blue Team)
Cyclops (New Xavier School)
Mister Sinister
RUNS IN THE FAMILY
Havok: Gain 2 Plasma Charge(s) after each Special Attack.

Cyclops (Blue Team): Armor Breaks effects increase their Duration by 100%.

Cyclops (New Xavier School): Armor Breaks effects increase their Duration by 100%.

Mister Sinister: Well timed Blocks against contact attacks inflict Degeneration, dealing 30% of Attack as Direct Damage over 1 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Quake
Hawkeye
S.H.I.E.L.D AGENTS
All Champions gain +[8, 10]% Ability Accuracy.
Quake
Black Widow
S.H.I.E.L.D CLEARANCE
Quake and Black Widow gain +15% Ability Accuracy, Duration and Potency.
Hawkeye
Black Widow
Black Widow (Deadly Origin)
Nick Fury
Quake
S.H.I.E.L.D. SURVIVAL GEAR
Hawkeye: Gain Immunity to Poison Debuffs from Non-Mutant Champions.
Synergy Champions: +7% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Ham
Mojo
SATURDAY MORNING CARTOONS
Spider-Ham: Whenever an Opponent's Special Attack triggers at least 10 Porker Poppers, the Special Attack Damage Reduction from Spider-Nonsense is 100% stronger for that Special Attack.

Mojo: Whenever one of the Opponent’s Buff’s expires or is Nullified, pause the Anti-Life field for 1 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Thing
Korg
SCHOOL OF HARD ROCKS
Thing: Fury effects generated from removing Rock Stacks are 33% more effective.

Korg: Start the fight with 2 additional Rock Shield charges.
Unique Synergy: Does not stack with duplicate synergies.
Captain America (Infinity War)
Captain America
Hulk
Hulk (Ragnarok)
SCIENCE EXPERIMENT
Science Champions place a Passive Weakness on the Opponent reducing their Attack by 50% except while being struck by them.
Unique Synergy: Does not stack with duplicate synergies.
Sentinel
Ant-Man
Electro
Void
SCIENCE RESEARCH
Sentinel: Reduce the duration of the target’s Debuff effects by 50% when facing a target of the Science Class.
Unique Synergy: Does not stack with duplicate synergies.
Attuma
Namor
SEA-WORN ENEMIES
Attuma: Gain 20% Bleed potency, but suffer -25% Ability Accuracy.

Namor: Gain 90 Critical Damage Rating, but suffer -25% Bleed Ability Accuracy.
Unique Synergy: Does not stack with duplicate synergies.
Silver Surfer
Doctor Strange
Hulk
SECRET DEFENDERS
Silver Surfer: Reduce the cooldown of Silver Surfer's Power Cosmic Buff by 3.0 seconds.

Doctor Strange: Increase the Potency of each of Doctor Strange's Blessings by 25%.

Hulk: Hulk is Immune to Buffs. Whenever a Buff is prevented by Immunity, inflict a -250 Physical Vulnerability Debuff for 3 seconds. Max: 20.
Unique Synergy: Does not stack with duplicate Synergies.
Daredevil (Hell's Kitchen)
Elektra
Psylocke
SECRET OF THE HAND
Daredevil (Hell's Kitchen): Knock the opponent down: 100% chance to inflict a 12 second Disorient Debuff, reducing Defensive Ability Accuracy & Block Proficiency by 35%.

Elektra: Critical Hits gain +20% additional Power.

Psylocke: +25% Attack rating during Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.
Omega Red
Red Hulk
Red Skull
SEEING RED
Omega Red: Well Timed Blocks have a 100% chance to inflict 1 Death Spore up to a max of 30 Spores total.

Red Hulk: +25% Power Rate against Incinerated opponents.

Red Skull: While under 1 Bar of Power, Charging Red Skull’s Heavy Attack grants an Unstoppable Buff for 2 seconds. If Hit while Unstoppable, the Buff is removed and Red Skull immediately executes the Heavy Attack.
Unique Synergy: Does not stack with duplicate synergies.