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Havok
Cyclops (Blue Team)
Cyclops (New Xavier School)
Mister Sinister
RUNS IN THE FAMILY
Havok: Gain 2 Plasma Charge(s) after each Special Attack.

Cyclops (Blue Team): Armor Breaks effects increase their Duration by 100%.

Cyclops (New Xavier School): Armor Breaks effects increase their Duration by 100%.

Mister Sinister: Well timed Blocks against contact attacks inflict Degeneration, dealing 30% of Attack as Direct Damage over 1 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Quake
Hawkeye
S.H.I.E.L.D AGENTS
All Champions gain +[8, 10]% Ability Accuracy.
Quake
Black Widow
S.H.I.E.L.D CLEARANCE
Quake and Black Widow gain +15% Ability Accuracy, Duration and Potency.
Hawkeye
Black Widow
Black Widow (Deadly Origin)
Nick Fury
Quake
S.H.I.E.L.D. SURVIVAL GEAR
Hawkeye: Gain Immunity to Poison Debuffs from Non-Mutant Champions.
Synergy Champions: +7% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Ham
Mojo
SATURDAY MORNING CARTOONS
Spider-Ham: Whenever an Opponent's Special Attack triggers at least 10 Porker Poppers, the Special Attack Damage Reduction from Spider-Nonsense is 100% stronger for that Special Attack.

Mojo: Whenever one of the Opponent’s Buff’s expires or is Nullified, pause the Anti-Life field for 1 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Thing
Korg
SCHOOL OF HARD ROCKS
Thing: Fury effects generated from removing Rock Stacks are 33% more effective.

Korg: Start the fight with 2 additional Rock Shield charges.
Unique Synergy: Does not stack with duplicate synergies.
Captain America (Infinity War)
Captain America
Hulk
Hulk (Ragnarok)
SCIENCE EXPERIMENT
Science Champions place a Passive Weakness on the Opponent reducing their Attack by 50% except while being struck by them.
Unique Synergy: Does not stack with duplicate synergies.
Sentinel
Ant-Man
Electro
Void
SCIENCE RESEARCH
Sentinel: Reduce the duration of the target’s Debuff effects by 50% when facing a target of the Science Class.
Unique Synergy: Does not stack with duplicate synergies.
Attuma
Namor
SEA-WORN ENEMIES
Attuma: Gain 20% Bleed potency, but suffer -25% Ability Accuracy.

Namor: Gain 90 Critical Damage Rating, but suffer -25% Bleed Ability Accuracy.
Unique Synergy: Does not stack with duplicate synergies.
Silver Surfer
Doctor Strange
Hulk
SECRET DEFENDERS
Silver Surfer: Reduce the cooldown of Silver Surfer's Power Cosmic Buff by 3.0 seconds.

Doctor Strange: Increase the Potency of each of Doctor Strange's Blessings by 25%.

Hulk: Hulk is Immune to Buffs. Whenever a Buff is prevented by Immunity, inflict a -250 Physical Vulnerability Debuff for 3 seconds. Max: 20.
Unique Synergy: Does not stack with duplicate Synergies.
Daredevil (Hell's Kitchen)
Elektra
Psylocke
SECRET OF THE HAND
Daredevil (Hell's Kitchen): Knock the opponent down: 100% chance to inflict a 12 second Disorient Debuff, reducing Defensive Ability Accuracy & Block Proficiency by 35%.

Elektra: Critical Hits gain +20% additional Power.

Psylocke: +25% Attack rating during Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.
Omega Red
Red Hulk
Red Skull
SEEING RED
Omega Red: Well Timed Blocks have a 100% chance to inflict 1 Death Spore up to a max of 30 Spores total.

Red Hulk: +25% Power Rate against Incinerated opponents.

Red Skull: While under 1 Bar of Power, Charging Red Skull’s Heavy Attack grants an Unstoppable Buff for 2 seconds. If Hit while Unstoppable, the Buff is removed and Red Skull immediately executes the Heavy Attack.
Unique Synergy: Does not stack with duplicate synergies.
Green Goblin
Spider-Man (Classic)
Spider-Man (Symbiote)
Spider man (Miles Morales)
Spider Man (Stark Enhanced)
SEETHING HATRED
Green Goblin: +15% Pumpkin Bomb damage for each Cunning and Madness charge.

Spider-Man (Classic): Critical Hits generate 15% more Power.

Spider-Man (Symbiote): Critical Hits generate 15% more Power.

Spider man (Miles Morales): Critical Hits generate 15% more Power.

Spider Man (Stark Enhanced): Critical Hits generate 15% more Power.
Unique Synergy: Does not stack with duplicate synergies.
Red Goblin
Carnage
Green Goblin
SELF CENTERED
Red Goblin: Gain +1 Bloodlust the first time Red Goblin wins a Fight in a Quest.

Carnage: When Genetic Mutation ends, generate 1 additional Permanent Buff. After reaching max Permanent Buffs, future Symbiotic Creation Buffs last 10 seconds.

Green Goblin: Launching Special Attacks sets Madness and Cunning stacks to be even. While both stacks are even, increase Ability Accuracy by 25%.
Unique Synergy: Does not stack with duplicate Synergies.
Nebula
Guillotine 2099
Hulkbuster
Nimrod
Ultron
SELF-REPAIRING SUFFICIENCY
Nebula: Start the fight with 1 additional Self-Repair Charge. Self-Repair Recharges 25% faster when Charges run out.
Solo: Only affects this Champion and does not stack.
Warlock
Magik
Sunspot
SELFFRIENDS
Warlock: Special Attacks generate -70% less Power in Opponents.

Magik: Attack Rating is increased by 50% while in Limbo.

Sunspot: Incinerates have 25% increased duration.
Unique Synergy: Does not stack with duplicate synergies.
Vision (Aarkus)
Black Widow (Claire Voyant)
Captain America
Old Man Logan
SENIOR'S DISCOUNT
Synergy Members: Special Attacks cost 15% less Power.
Unique Synergy: Does not stack with duplicate synergies.
Omega Sentinel
Captain Britain
Psylocke
SENTENCED TO DEATH
Omega Sentinel: Whenever the Opponent is inflicted with a Cowardice Debuff remove 1 Prowess effect from them.

Captain Britain: Landing a Critical Hit on the last hit of Special Attack 1 grants an Unblockable Buff during the next Special Attack.

Psylocke: Knocking an Opponent down with a Heavy Attack grants Psylocke 2 psi-charges.
Unique Synergy: Does not stack with duplicate synergies.
Storm (Pyramid X)
Bishop
SETUP AND SPIKE
Storm (Pyramid X): Prowess Buffs last 4 seconds longer.

Bishop: Every 15 seconds generate a Power Gain Buff granting 20% of a bar of Power over 5 seconds. While this Power Gain Buff is active, each Prowess increases Special Attack Damage by an additional +3%.
Unique Synergy: Does not stack with duplicate Synergies.
Shang Chi
Mister Negative
SHADOWLAND
Shang Chi: Dodging an attack with Perfect Timing inflicts a Falter Passive, causing 100% of the Opponent’s attacks to Miss for 2 second(s). Contact Attacks bypass this Falter and remove the effect.

Mister Negative: Degeneration Debuffs triggered in Special Attack 2 have a 10% chance to inflict an additional copy of themselves.
Unique Synergy: Does not stack with duplicate synergies.