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Gladiator
Praetor Of The Imperial Guard
All Champions except Gladiator: Gain 5% Attack Rating and 5% Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.
Kraven
Tigra
PRESSURE POINTS
Kraven: On a Critical Hit, inflict a Fragility Debuff for 5 seconds. When attacking a Fragile Opponent, increase Critical Damage Rating by [200, 230] and decrease their Block Proficiency by 15%.

Tigra: While the Opponent is Neutralized Tigra gains [1500, 1710] Critical Rating.
Unique Synergy: Does not stack with duplicate synergies.
Terrax
Annihilus
PRISONER
Terrax: +15% Attack Rating.

Annihilus: All Fury Buffs last an additional 1 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Black Cat
Domino
Longshot
PROBABILITY PALS
Black Cat: Black Cat starts the fight with 40 additional hits in her Combo Meter.

Domino: Whenever an Opponent’s ability fails to trigger, Domino adds +1 Combo to her Combo Meter.

Longshot: When Longshot gains Good Karma, he has a 39% chance to gain an additional 1 Good Karma.
Unique Synergy: Does not stack with duplicate synergies.
Longshot
Domino
Probably OP:
Longshot: Pure of Heart lasts 4 seconds longer.

Domino: If an Opponent was not Struck over the Duration of a Stun, Domino gains 10% of a bar of Power.
Unique Synergy: Does not stack with duplicate Synergies.
Scorpion
Spider-Ham
PROBLEMS WITH CARTOONS
Scorpion: 25% chance to inflict Sting Debuffs on light attacks.

Spider-Ham: When triggering Porker Poppers 30% chance to inflict a Concussion Debuff, reducing Ability Accuracy by 40% for 10 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Taskmaster
Crossbones
PROFESSORS IN CRIME
Taskmaster: Instantly gain 5% of his Max Power each time he Exploits a Weakness.

Crossbones: Gain 2 additional Fury Buff(s) when entering Overrun.
Unique Synergy: Does not stack with duplicate synergies.
Okoye
Valkyrie
Medusa
Heimdall
Protector of Crowns
Synergy Champions: +3% Health and +3% Attack Rating. Once per fight, Evading an attack, Landing a Heavy Attack, or Knocking the Opponent down with a Special Attack grants +7% Attack Rating until the end of the fight.
Unique Synergy: Does not stack with duplicate synergies.
Moondragon
Mantis
PSYCHO-MANTIS
Moondragon: While Psionic Transcendence is not active, gain a +750 Energy Resistance Buff.

Mantis: Start each fight with a dormant Physical Resistance Charge. When struck, the charge is removed and replaced with a 1400 Physical Resistance Buff for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Jack O’Lantern
Green Goblin
Red Goblin
Pumpkin Spice Bombings
Jack O’Lantern: Special 2 only inflicts Poison Debuffs, replacing the Incinerate Debuffs

Green Goblin: Pumpkin Bomb effects from Special Attacks have their chance increased to 100%. This does not increase the chance of Super Bombs.

Red Goblin: Special 2 produces an extra Carnage Bomb per Carnage Bomb hit.
Unique Synergy: Does not stack with duplicate synergies.
Cyclops (Blue Team)
America Chavez
Punch Dimension
Cyclops (Blue Team): Beam hits deal additional bursts of Physical Damage equal to 10% of hit damage dealt.

America Chavez: The final 3 hits of Special Attack 2 deal additional bursts of Physical Damage equal to 20% of hit damage dealt.
Unique Synergy: Does not stack with duplicate synergies.
Jessica Jones
Dragon Man
Purgatory
Storm (Pyramid X)
Thanos
Baron Zemo
PUNCHING PURPLE PEOPLE
Jessica Jones: Striking a Champion who has an active Unblockable, True Damage, or Prowess effect grants a Fury Passive, increasing Attack Rating by 30% for 8 seconds.
Synergy Members: Filling a Bar of Power randomly grants a dormant Unblockable, True Damage, or 40% Prowess Charge. Charges are removed and replaced with their corresponding Buffs during this Champion’s next Special Attack.
Unique Synergy: Does not stack with duplicate synergies.
Cosmic Ghost Rider
Punisher 2099
Punishments of Infinite Variety
Cosmic Ghost Rider: The first time your Opponent reaches Max Power each fight, drain 5% of their Power and trigger a Power Lock Debuff lasting 2 seconds.

Punisher 2099: Heavy Attacks have a 100% chance to grant a Fury Buff increasing Attack Rating by 25% for 10 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Titania
Captain Marvel (Classic)
Storm
Yondu
PUNK'S PANACHE
Synergy Members: Special Attacks don't generate Power for the Opponent if Titania is alive, and gain +10% Attack Rating if Captain Marvel is alive, +750 Critical Rating if Storm is alive, and +400 Critical Damage Rating if Yondu is alive.
Unique Synergy: Does not stack with duplicate synergies.
Gladiator
Sorcerer Supreme
Hulk (Ragnarok)
Punk’s Pizzazz
Synergy Champions: Heavy Attacks are Passively Unblockable if Gladiator is alive, and they gain +10% Attack Rating if Sorcerer Supreme is alive, +750 Critical Rating if Hulk (Ragnarok) is alive.
Unique Synergy: Does not stack with duplicate synergies.
Hulk (Ragnarok)
Loki
PUNY GOD
Hulk (Ragnarok): +1000 Physical Resistance while Unstoppable.

Loki: Basic Attacks against Loki have a 10% chance to miss, while his Opponent is under the effect of any Buff.
Unique Synergy: Does not stack with duplicate synergies.
Psycho-Man
Mangog
PURE HATRED
Psycho-Man: The Control Box is unable to cycle out of Hate mode and Opponents are 20% more likely to use a Heavy Attack. Personal Shock Debuff potency is increased by +60%. Personal Fury Buffs refresh when the Fourth Light Attack lands a hit or it strikes into a block.

Mangog: Each stack of Hatred increases Regeneration Rate by 1%.
Unique Synergy: Does not stack with duplicate synergies.
Werewolf By Night
Moon Knight
Pure Instinct
Werewolf By Night: Dashing forward from outside of striking distance grants a 2% Fury Passive per Buff on the Opponent for 1.2 seconds. This Fury is paused during Basic and Special Attacks. Max stacks: 10.
Solo Synergy: Only affects this Champion and does not stack.
Jabari Panther
Apocalypse
Archangel
Juggernaut
Storm
PYRAMID X
Synergy Members: Gain a Precision Buff during Special Attacks for each Damage over Time Debuff and Stagger Passive on the Opponent, each increasing Critical Rating by +375.
Unique Synergy: Does not stack with duplicate synergies.
Shuri
Beast
Iron Man (Infamous)
Mister Fantastic
Q BRANCH
Synergy Members: Start each fight with an indefinite Failsafe Charge. When struck by a Special Attack 1 or 2, consume the Failsafe to gain an Indestructible Passive for the duration of the Special.
Unique Synergy: Does not stack with duplicate synergies.