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SEETHING HATRED

Green Goblin
Spider-Man (Classic)
Spider-Man (Symbiote)
Spider man (Miles Morales)
Spider Man (Stark Enhanced)
Green Goblin+15% Pumpkin Bomb damage for each Cunning and Madness charge.

Spider-Man (Classic)Critical Hits generate 15% more Power.

Spider-Man (Symbiote)Critical Hits generate 15% more Power.

Spider man (Miles Morales)Critical Hits generate 15% more Power.

Spider Man (Stark Enhanced)Critical Hits generate 15% more Power.

Unique Synergy: Does not stack with duplicate synergies.

SEEING RED

Omega Red
Red Hulk
Red Skull
Omega RedWell Timed Blocks have a 100% chance to inflict 1 Death Spore up to a max of 30 Spores total.

Red Hulk+25% Power Rate against Incinerated opponents.

Red SkullWhile under 1 Bar of Power, Charging Red Skull’s Heavy Attack grants an Unstoppable Buff for 2 seconds. If Hit while Unstoppable, the Buff is removed and Red Skull immediately executes the Heavy Attack.

Unique Synergy: Does not stack with duplicate synergies.

SECRET OF THE HAND

Daredevil (Hell's Kitchen)
Elektra
Psylocke
Daredevil (Hell's Kitchen)Knock the opponent down: 100% chance to inflict a 12 second Disorient Debuff, reducing Defensive Ability Accuracy & Block Proficiency by 35%.

ElektraCritical Hits gain +20% additional Power.

Psylocke+25% Attack rating during Special Attacks.

Unique Synergy: Does not stack with duplicate Synergies.

SECRET DEFENDERS

Silver Surfer
Doctor Strange
Hulk
Silver SurferReduce the cooldown of Silver Surfer's Power Cosmic Buff by 3.0 seconds.

Doctor StrangeIncrease the Potency of each of Doctor Strange's Blessings by 25%.

HulkHulk is Immune to Buffs. Whenever a Buff is prevented by Immunity, inflict a -250 Physical Vulnerability Debuff for 3 seconds. Max: 20.

Unique Synergy: Does not stack with duplicate Synergies.

SEA-WORN ENEMIES

Attuma
Namor
AttumaGain 20% Bleed potency, but suffer -25% Ability Accuracy.

NamorGain 90 Critical Damage Rating, but suffer -25% Bleed Ability Accuracy.

Unique Synergy: Does not stack with duplicate synergies.

SCIENCE RESEARCH

Sentinel
Ant-Man
Electro
Void
SentinelReduce the duration of the target’s Debuff effects by 50% when facing a target of the Science Class.

Unique Synergy: Does not stack with duplicate synergies.

SCIENCE EXPERIMENT

Captain America (Infinity War)
Captain America
Hulk
Hulk (Ragnarok)

Science Champions place a Passive Weakness on the Opponent reducing their Attack by 50% except while being struck by them.
Unique Synergy: Does not stack with duplicate synergies.

SCHOOL OF HARD ROCKS

Thing
Korg
ThingFury effects generated from removing Rock Stacks are 33% more effective.

KorgStart the fight with 2 additional Rock Shield charges.

Unique Synergy: Does not stack with duplicate synergies.

SATURDAY MORNING CARTOONS

Spider-Ham
Mojo
Spider-HamWhenever an Opponent's Special Attack triggers at least 10 Porker Poppers, the Special Attack Damage Reduction from Spider-Nonsense is 100% stronger for that Special Attack.

MojoWhenever one of the Opponent’s Buff’s expires or is Nullified, pause the Anti-Life field for 1 second(s).

Unique Synergy: Does not stack with duplicate synergies.

S.H.I.E.L.D. SURVIVAL GEAR

Hawkeye
Black Widow
Black Widow (Deadly Origin)
Nick Fury
Quake
HawkeyeGain Immunity to Poison Debuffs from Non-Mutant Champions.

Synergy Champions: +7% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.

S.H.I.E.L.D CLEARANCE

Quake
Black Widow

Quake and Black Widow gain +15% Ability Accuracy, Duration and Potency.

S.H.I.E.L.D AGENTS

Quake
Hawkeye

All Champions gain +[8, 10]% Ability Accuracy.

RUNS IN THE FAMILY

Havok
Cyclops (Blue Team)
Cyclops (New Xavier School)
Mister Sinister
HavokGain 2 Plasma Charge(s) after each Special Attack.

Cyclops (Blue Team)Armor Breaks effects increase their Duration by 100%.

Cyclops (New Xavier School)Armor Breaks effects increase their Duration by 100%.

Mister SinisterWell timed Blocks against contact attacks inflict Degeneration, dealing 30% of Attack as Direct Damage over 1 second(s).

Unique Synergy: Does not stack with duplicate synergies.

RULE OF LAW

Daredevil (Hell's Kitchen)
Daredevil (Classic)
Ronan
She-Hulk
Daredevil (Hell's Kitchen)Special Attacks have a 20% chance to inflict a Stun Debuff. Duration is 1.25 seconds per level of Special Attack used.

Synergy Champions: +10% Attack Rating.
Unique Synergy: Does not stack with duplicate Synergies.

ROYALS

Black Panther
Storm
Black PantherGain a 1 second Unblockable Passive when activating a Special Attack during Panther’s Might.

StormEach Shock Debuff on the opponent grants +20% Special Attack Damage, Max Potency at 5 Shocks.

Unique Synergy: Does not stack with duplicate synergies.

ROTTED SOULS

Iron Man (Infamous)
Mephisto
Iron Man (Infamous)Whenever Infamous Iron Man is immune to an effect, he deals the Opponent a burst of Energy Damage equal to 200% of his Attack Rating. Each subsequent time this ability triggers, its potency is reduced by 20%.

MephistoDuration of Soul imprisonment is doubled.

Unique Synergy: Does not stack with duplicate synergies.

ROOMMATES

Spot
Mysterio
SpotGain 10% Rupture Debuff Potency.

MysterioGain 1 Chemical Gas when a hit Misses Mysterio. 10 second cooldown.

Unique Synergy: Does not stack with duplicate synergies.

ROMANCE - MOJO

Mojo
MojoGain +5% Power Gain.

Solo: Mojo only loves himself.
Unique Synergy: Does not stack with duplicate synergies.

ROMANCE

Domino
Colossus
Wolverine

All Teammates gain +[3, 4, 5]% Power Gain.

ROBOT UPRISING

Warlock
Ultron (Classic)
Ultron
Vision
Vision (Age of Ultron)

Whenever any teammate would receive a Debuff they are immune to, they gain a Fury Buff, increasing Attack Rating by 60% for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.