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Negasonic Teenage Warhead
Deadpool
Goldpool
Platinum Pool
Deadpool (X-Force)
One Was Already Too Many
Negasonic Teenage Warhead: Opponents that are Immune to personal Incinerates are inflicted with matching Rupture Passives with 60% of the original potency. These Ruptures are still treated as Incinerates by the rest of Negasonic’s abilities and effects.

Deadpool: +10% Bleed and Regeneration potency.

Goldpool: +10% Bleed and Regeneration potency.

Platinum Pool: +10% Bleed and Regeneration potency.

Deadpool (X-Force): +10% Bleed and Regeneration potency.
Unique Synergy: Does not stack with duplicate synergies.
Invisible Woman
Emma Frost
Magik
Omega Red
Sabretooth
Sentry
ONE WAY OR ANOTHER
Passive Fury, Prowess, Regeneration, Indestructible, and Limbo effects last 10% longer.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Man (Classic)
Nightcrawler
Wolverine
ONOMATOPOTENT
Spider-Man (Classic): Webbing falls off 50% slower.

Nightcrawler: +40% flat Evade Ability Accuracy.

Wolverine: Bleed duration is increased by 15%.
Unique Synergy: Does not stack with duplicate synergies.
Moondragon
Iron Fist
Iron Fist (Immortal)
OPEN PALM TECHNIQUE
Moondragon: Hitting the Opponent’s Block with Basic Attacks grants a non-stacking Fury Passive increasing Attack Rating by 20% for 4 seconds.

Iron Fist: Critical Hits grant an indefinite Heavy Proficiency Passive increasing Attack Rating by +20% during Heavy Attacks. Max Stacks: 3. These Passives are removed after landing a Heavy Attack.

Iron Fist (Immortal): Critical Hits grant an indefinite Heavy Proficiency Passive increasing Attack Rating by +20% during Heavy Attacks. Max Stacks: 3. These Passives are removed after landing a Heavy Attack.
Unique Synergy: Does not stack with duplicate synergies.
Silk
Spider-Gwen
Spider man (Miles Morales)
ORDER OF THE WEB
Synergy Champions: Incoming Degeneration effects from Champions suffer -30% potency for each unique Synergy Champion on the team.
Unique Synergy: Does not stack with duplicate synergies.
Iron Patriot
Red Goblin
OSBORN TO BE WILD
Iron Patriot: Arc Overload grants a Fury Buff increasing Attack Rating by 300% for 30 seconds, no longer burns out Iron Patriot’s Suit, and can be reactivated after a 60 second cooldown.

Red Goblin: While Frenzy is active, Fury and Energize Buffs have 15% increased Potency.
Unique Synergy: Does not stack with duplicate Synergies.
Sentry
Void
OTHER HALF
Sentry: After a Special 3 Attack, Sentry inflicts Fear of the Void. Fear of the Void combines Agility, Fatigue, and Petrify Debuffs, as well as increasing Sentry's Attack Rating by 50% for 40 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Galan
Mister Fantastic
OTHERWORLDLY TESTIMONY
Galan: All Incinerate Debuff durations are increased by 50%.

Mister Fantastic: Whenever a Personal Debuff expires on the Opponent, gain 20% of a bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
Guillotine 2099
Guillotine
Morningstar
OUR SHARED CURSE
Guillotine 2099: +30% Degeneration Potency.

Guillotine: +20% Personal Bleed Ability Accuracy and Duration.

Morningstar: +300 Critical Damage per Captured Soul.
Unique Synergy: Does not stack with duplicate synergies.
America Chavez
Ghost Rider
The Hood
OUT OF THIS WORLD
America Chavez: Dark Dimension Regenerates 30% of damage dealt to the Opponent by this Dimension.
Dimensional Beings: +25% resistance to Degeneration Damage.
Unique Synergy: Does not stack with duplicate Synergies.
Void
Black Widow
Captain America
Hawkeye
Vision
OVERCOMING FEAR
Void: Fear of the Void activates at the start of the fight for 30 seconds against the Avengers.
Avengers: +15% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Mephisto
Doctor Strange
Ghost Rider
PACT WITH A DEMON
Mephisto: +70% Incinerate Energy Damage.

Doctor Strange: Life Steal Heals an additional 70%.

Ghost Rider: +10% Attack at the start of the fight.
Unique Synergy: Does not stack with duplicate synergies.
Prowler
Spider man (Miles Morales)
White Tiger
Electro
Vulture
Parallel Enemies
Prowler: Punishing the Opponent’s Special Attacks grants a +300 Cruelty Passive for 10 seconds.

Spider man (Miles Morales): Increase Spider-Camo Miss chance by +35% flat.

White Tiger: Punishing the Opponent’s Special Attacks grants a +300 Cruelty Passive for 10 seconds.

Electro: Static Shock also triggers on Electro’s attacks at 50% potency.

Vulture: Immunity to Nullify.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Octopus
Electro
PARTICLE PHYSICS
Doctor Octopus: When a Breakthrough expires, Research Categories reset to 50.

Electro: Gains 50% additional Power from Critical Hits.
Unique Synergy: Does not stack with duplicate synergies.
Hawkeye
Kate Bishop
Ronin
PARTNERS
Hawkeye: Failing to activate a Perfect Release Bonus only removes one Dialed In Passive.

Kate Bishop: Activating a Perfect Release Bonus during a Special Attack 2 grants 2 additional Dialed In Passives.

Ronin: Entering Wraith Stance refreshes personal Disorient effects on the Opponent and pauses them for 3 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Captain Marvel
Nick Fury
PARTNERS IN S.H.I.E.L.D
Captain Marvel: Each Energy Charge lasts an additional 1 second while in Binary Ignition.

Nick Fury: Each Tactical Advantage charge lasts an additional 1 second.
Unique Synergy: Does not stack with duplicate synergies.
Sersi
Hercules
PARTYGOERS
Sersi: Special Hits that break through an Opponent’s Block with an Unblockable Buff become Guaranteed Critical Hits.

Hercules: Feat of Strength: Gain 1 Indefinite Strength for every 10 hits in the Combo Meter.
Unique Synergy: Does not stack with duplicate synergies.
Thing
Human Torch
PASSIVE AGGRESSIVE
Thing: When Thing is at 20 Rock Stacks, any additional stacks he would gain are immediately converted into Passive Fury effects.
Unique Synergy: Does not stack with duplicate synergies.
Maestro
The Overseer
Past and Future Self
Maestro: Gain Neutronium 20% faster. During Superior Rage, Neutronium expires 20% slower.

The Overseer: Personal Special Concussion Debuffs gain +10% flat potency but their stack limit is reduced to 4.
Unique Synergy: Does not stack with duplicate synergies.
Captain Britain
Psylocke
PAST AND PRESENT SELF
Captain Britain: Striking an Opponent with a Critical Hit inflicts a non-stacking Degeneration Debuff dealing 50% Attack Rating as Direct Damage over 6 seconds.

Psylocke: Striking an Opponent with a Critical Hit inflicts a non-stacking Degeneration Debuff dealing 50% Attack Rating as Direct Damage over 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.