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Doctor Strange
Mordo
Symbiote Supreme
MYSTIC MASTERS
Doctor Strange: Deal 50% of Base Attack as Direct Damage when Nullifying a Buff off the Opponent.

Mordo: Mordo places a Detonate Buff on the opponent at the start of the fight which lasts 20 seconds and deals 50% of Mordo’s Base Attack as a burst of Energy Damage when it’s Nullified or Expires.

Symbiote Supreme: Begin the fight with 1 bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
Sentinel
Mordo
Morningstar
The Hood
MYSTIC OBSERVATION
Sentinel: Reduce the duration of the target’s Power Lock effects by 50% and generate 50% Power each time a Power Lock expires when facing a target of the Mystic Class.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Doom
Morningstar
MYSTIC TYRANTS
Doctor Doom: Successful Nullifies deal a burst of energy damage equal to 20% of Doom's Attack.
Solo: Only affects this Champion and does not stack.
The Leader
She-Hulk
Need a Good Lawyer
The Leader: Inflicting a personal Wither or Spectre Debuff pauses Leader’s Vitality Passive for 1.5 seconds.

She-Hulk: While the Opponent is affected with a Regeneration effect and She-Hulk’s personal Petrify, personal Fury effects expire 35% slower.
Unique Synergy: Does not stack with duplicate synergies.
Hawkeye
Abomination
Abomination (Immortal)
Diablo
King Groot
NERVE TOXIN ARROWS
Hawkeye: Arrow strikes Pause all Slow Debuffs on the opponent for 6 seconds per level of Special Attack.
Other Synergy Champions: +7% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Hawkeye
Wiccan
NEW AVENGERS
Hawkeye: Inflict Rupture and Critical Rupture instead of Bleed and Critical Bleed when fighting Bleed Immune Champions.
#New Avengers: Gain [400, 420, 450] Critical Rating.
Unique Synergy: Does not stack with duplicate synergies.
The Leader
Elsa Bloodstone
Mole Man
New Intelligencia Takedown
The Leader: Inflicting a personal Wither or Spectre Debuff pauses Leader’s Power Dissolve Debuff for 1.5 seconds.

Elsa Bloodstone: Performing a personal Counter-Evade pauses personal Debuffs for 3 seconds. Firing a Hellfire Round or Behemoth Buster with a Basic Attack shortens the Evade cooldown by 1 second.

Mole Man: Personal Shocks are paused during Moleman’s Special Attacks.
Unique Synergy: Does not stack with duplicate synergies.
Sunspot
Cable
Warlock
NEW MUTANTS
Mutant Champions: Ability Accuracy is increased by 30% during Special Attacks. Increased to up to 60% based on Sunspot's Signature level.
Unique Synergy: Does not stack with duplicate Synergies.
Darkhawk
Night Thrasher
Nova
NEW WARRIOR BLOOD
Darkhawk: Starts the fight with a Permanent Armor Up Buff increasing Armor Rating by 45%.

Night Thrasher: The Shock Baton Gadget Debuff passively reduces Defensive Combat Power Rate by 30%.

Nova: Heavy Attacks have a 50% chance to refresh Nova Surge Buffs.
Unique Synergy: Does not stack with duplicate synergies.
Nimrod
Omega Sentinel
NEW WAVE
Nimrod: If a personal Shock effect is prevented by Immunity. Nimrod inflicts matching Incinerate Debuffs instead. Incinerate reduces Block Proficiency by 50% and prevents the activation of Perfect Block.
Robots: +5% Combat Power Rate for each Shock on the Opponent. Max 50%.
Unique Synergy: Does not stack with duplicate Synergies.
Howard The Duck
Daredevil (Hell's Kitchen)
Doctor Strange
Luke Cage
Spider-Man (Stealth-Suit)
NEW YORK BRAWLERS
Howard The Duck: Opponent suffers -65% Evade Ability Accuracy.
Other Synergy Champions: Up to +15% Attack Rating, based on missing health.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Voodoo
Magik
Wiccan
Wong
NEXT IN LINE
Doctor Voodoo: Power Gain and Power Leech Effects gain 25% increased duration.

Magik: If the Opponent has 1 or more Buffs active, Special Attack 1 becomes Unblockable.

Wiccan: Spell Pause duration increases by 2 second(s).

Wong: Spell durations are increased by 20%.
Unique Synergy: Does not stack with duplicate synergies.
Hercules
NEXT ROUND ON ME
#Hero Champions: While Hercules is alive gain +[10, 15]% Attack Rating while under the effects of Poison from the Liquid Courage Mastery.
Unique Synergy: Does not stack with duplicate synergies.
Photon
Elsa Bloodstone
Nextwave!
Photon: Unblockable hits deal 4% of Attack as a burst of Direct Damage for each personal Debuff on the Opponent.

Elsa Bloodstone: When Counter-Attacking with her Revolver, Elsa inflicts a Slow Passive for 2.5 seconds. She cannot Miss while this effect is active.
Unique Synergy: Does not stack with duplicate synergies.
Nick Fury
NICK'S LEADERSHIP
All Hero Champions except Nick: 10% Attack Rating. This boost is doubled if Nick is Dead.
Unique Synergy: Does not stack with duplicate synergies.
Darkhawk
Moon Knight
Night Thrasher
NIGHT HAWKS
Darkhawk: Start the fight in a random mode.

Moon Knight: New and Waxing Moons grant 30% of Max Power over 6 seconds at the beginning of the fight. Full and Waning Moons grant 10% of Max Health over 3 seconds at the beginning of the fight.

Night Thrasher: Enemies have -20% Armor Rating for each unique debuff on them.
Unique Synergy: Does not stack with duplicate synergies.
Black Bolt
Daredevil (Hell's Kitchen)
Hawkeye
Hit-Monkey
NO EVIL
Black Bolt: Critical Rating is increased by 300 for each Buff on Black Bolt.

Daredevil (Hell's Kitchen): +100% Perfect Block chance vs. Non-Contact Physical Attacks.

Hawkeye: Arrow strikes gain +20% Attack Rating against Bleeding opponents.

Hit-Monkey: The last 3 Hits of each Heavy Attack are Guaranteed Critical Hits.
Unique Synergy: Does not stack with duplicate synergies.
Sabretooth
Black Panther
Black Panther (Civil War)
Killmonger
NO MERCY
Sabretooth: Inflicting a Debuff reduces the opponent’s Ability Accuracy by 100% for 0.7 seconds.

Black Panther: +30% Offensive Combat Power Rate when hitting opponents that are suffering from a Debuff.

Black Panther (Civil War): +30% Offensive Combat Power Rate when hitting opponents that are suffering from a Debuff.

Killmonger: +30% Offensive Combat Power Rate when hitting opponents that are suffering from a Debuff.
Unique Synergy: Does not stack with duplicate synergies.
Sauron
Doctor Strange
Mister Sinister
NO MORE PATIENTS
Sauron: Whenever an Opponent heals, gain a 2% Regen Passive for 2 seconds. This goes on Cooldown for 5 seconds. Once this has been triggered 4 times, Inflict Heal Block Passive for 12 seconds.

Doctor Strange: Whenever an Opponent heals, gain a 2% Regen Passive for 2 seconds. This goes on Cooldown for 5 seconds. Once this has been triggered 4 times, Inflict Heal Block Passive for 12 seconds.

Mister Sinister: Whenever an Opponent heals, gain a 2% Regen Passive for 2 seconds. This goes on Cooldown for 5 seconds. Once this has been triggered 4 times, Inflict Heal Block Passive for 12 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Ant-Man
Black Cat
Shocker
NO SAFE IS SAFE
Ant-Man: The final hit of Special Attack 1 gains +5% Attack Rating for each Debuff on the Opponent.

Black Cat: Attacks that steal the Calling Card are Guaranteed Critical Hits.

Shocker: While Unblockable, gain +25% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.