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Colossus
Unstoppable Colossus
Red Guardian
LIVING STEEL CURTAIN
Colossus: Activating any Special Attack has a 50% chance to trigger a Unstoppable Buff, lingering 1.2 seconds after the Attack ends.

Unstoppable Colossus: Personal Fury Buffs gain an additional flat +10% chance to trigger and last 200% longer. Additionally landing a Heavy Attack pauses all personal Fury Buffs until another is gained.
Unique Synergy: Does not stack with duplicate synergies.
Black Bolt
Cyclops (New Xavier School)
Ikaris
LORDS OF ENERGY
Black Bolt: Gains an Energize Buff granting +100% Combat Power Rate for 4 seconds, when a Personal Stun Debuff is applied.

Cyclops (New Xavier School): Gains +25% Fury when inflicting a Armor Break Debuff for 10 seconds. Max Stack of 4.

Ikaris: Gains 1 bonus stacks of Incinerate on Special 1 when paired with Cyclops or Black Bolt (stacks if with both).
Unique Synergy: Does not stack with duplicate synergies.
Heimdall
Angela
Hela
LOST DAUGHTERS OF ASGARD
All Champions except Heimdall: Once per fight Heimdall will intercede on your behalf, dash back and hold Block for 1.5 seconds to gain an infinite Duration Fury Buff increasing Attack by 15% of Base Attack.
Unique Synergy: Does not stack with duplicate synergies.
Thor (Jane Foster)
Gorr
Korg
Thor (Ragnarok)
Valkyrie
LOVE & THUNDER
Synergy Champions: +5% Combat Power Rate, +130 Armor Rating, +5% Perfect Block Chance & +6% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Longshot
Rogue
Love Triangles:
Longshot: Longshot's Special 2 has a 42% chance to inflict an additional Incinerate for each Bad Karma removed by Fate Seal.

Rogue: Whenever stealing a Buff Rogue deals 20% of her Base Attack as Degeneration damage for each Buff stolen.
All Female Champions: Gain 200 Critical Rating and 12% increased Ability Accuracy.
Unique Synergy: Does not stack with duplicate Synergies.
Captain America
Captain America (WWII)
Captain America (Infinity War)
Punisher 2099
LOYAL MINISTER
Captain America: Clean hits gain +20% Attack rating if the opponent has a Stun, Bleed or Fatigue Debuff.

Captain America (WWII): Clean hits gain +20% Attack rating if the opponent has a Stun, Bleed or Fatigue Debuff.

Captain America (Infinity War): Clean hits gain +20% Attack rating if the opponent has a Stun, Bleed or Fatigue Debuff.

Punisher 2099: Begin the fight with 25% additional Battery charge.
Unique Synergy: Does not stack with duplicate synergies.
Black Widow
Hulk (Ragnarok)
LULLABY
Black Widow: Evade chance increases by 100%.

Hulk (Ragnarok): When Struck Hulk has a 20% chance to ready a SMASH for his next attack.
Unique Synergy: Does not stack with duplicate synergies.
Diablo
Doctor Octopus
Green Goblin
M.O.D.O.K.
MADCAP EXPERIMENTALISTS
Diablo: Special Attacks have a 70% chance to inflict a Stun Debuff, lasting 1.5 second(s) per level of Special Attack used.

Doctor Octopus: +35% Heal Block Debuff duration.

Green Goblin: +1.5% Attack Rating per Cunning / Madness Charge.

M.O.D.O.K.: +20% personal Debuff Duration.
Unique Synergy: Does not stack with duplicate synergies.
Red Guardian
Sabretooth
MAGNIFICENT MANES
Red Guardian: While the Ablative Shield is Fractured, gain an indefinite Passive Fury, granting +10% Attack Rating until the Shield is repaired.

Sabretooth: Potency of Fury effects are increased by 10%.
Unique Synergy: Does not stack with duplicate synergies.
Invisible Woman
Psycho-Man
MALICE
Invisible Woman: While Invisible, Attacks have a 25% chance to place a Fragility Debuff on the Opponent.

Psycho-Man: Psycho-Man’s Ability Accuracy reduction effects reduce Ability Accuracy by an additional -15% flat.
Unique Synergy: Does not stack with duplicate synergies.
White Tiger
Gladiator
Mano A Mano
White Tiger: Power Steal has a 49.5% chance of not going on cooldown.

Gladiator: Charging a Heavy Attack while the Opponent’s back is against the wall grants a Fury Buff increasing Attack Rating by +50.5% for 2 seconds, paused during Gladiator’s Special Attacks. Max stacks: 3.
Unique Synergy: Does not stack with duplicate synergies.
Hulk (Immortal)
Purgatory
MANY AS ONE
Hulk (Immortal): Triggering Immortality consumes 5% less Max Health as Gamma Radiation.

Purgatory: 20% chance per captured Class Soul to instantly Regenerate 20% Health just before being knocked out, once per fight.
Unique Synergy: Does not stack with duplicate synergies.
Captain Marvel (Classic)
Ms. Marvel
Captain Marvel
MARVELOUS
Captain Marvel (Classic): While Fury is active, Beam Attacks are Unblockable.

Ms. Marvel: While Fury is active, Beam Attacks are Unblockable.

Captain Marvel: Blocking energy-based attacks grants 2% of Max Power.
Unique Synergy: Does not stack with duplicate synergies.
Shang Chi
Iron Fist
Iron Fist (Immortal)
MASTER MARTIAL ARTISTS
Shang Chi: Start the fight with 4 Chi Charge(s).

Iron Fist: Each hit in all Special Attacks are Guaranteed Critical Hits and gain a flat +35% personal Armor Break Ability Accuracy.

Iron Fist (Immortal): Each hit in all Special Attacks are Guaranteed Critical Hits and gain a flat +35% personal Armor Break Ability Accuracy.
Unique Synergy: Does not stack with duplicate synergies.
Black Panther
Hercules
MASTERFUL COMBAT
Black Panther: Dashing back during a Basic Attack combo inflicts a non-stacking Infuriate Debuff for 5 seconds, making the Opponent more aggressive and reducing their Offensive Ability Accuracy by 30%. Cooldown 10 seconds.

Hercules: On activation of Special Attack 1 or 2, gain an Unblockable Buff for 3 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Moon Knight
Ronin
MASTERLESS
Moon Knight: 30% chance to instantly Regenerate 35% of damage taken when struck.

Ronin: Gain a Fury Buff increasing Attack Rating by 15% for 4 seconds upon switching Stances.
Unique Synergy: Does not stack with duplicate synergies.
Loki
Magneto
Magneto (House of X)
MASTERMINDS
All Champions gain +[17, 20]% Energy Damage once a Combo of 15 or more hits is reached.
Mister Sinister
M.O.D.O.K.
Kingpin
Ultron
MASTERMINDS
Mister Sinister: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.

M.O.D.O.K.: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.

Kingpin: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.

Ultron: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Guillotine
Morningstar
MASTERS OF THE SWORD
Guillotine: Temporary Soul Charges last 10 seconds longer.

Morningstar: At the start of the fight, if she has less than 2 Captured Souls, she gains 1.
Unique Synergy: Does not stack with duplicate synergies.
Bishop
Havok
Nova
MAXIMUM OUTPUT
Bishop: Receiving Energy Damage generates 1 additional stack of Prowess.

Havok: 10% chance to place a new Plasma Build Up Debuff on the Opponent when it is Removed or Purified.

Nova: Gain 1 Nova Charge each time Nova receives Energy Damage.
Unique Synergy: Does not stack with duplicate synergies.