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Karnak
Medusa
INHUMAN ROYAL FAMILY
Karnak: Striking into the opponent’s Block reduces their Ability Accuracy by 30% per Focus Charge.

Medusa: Heavy Attacks inflict indefinite Armor Break Debuffs to a max of 4.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
Groot
Rocket Raccoon
The Hood
INSEPARABLE
All Champions gain +[7, 8, 9]% Special 3 Damage
Shocker
Daredevil (Classic)
Doctor Octopus
Mysterio
Rhino
Scorpion
INSIDIOUS
Synergy Champions: Gain +250 Critical Resistance, doubled when fighting #Spider-Verse Heroes.
Unique Synergy: Does not stack with duplicate synergies.
Masacre
Deadpool
Deadpool (X-Force)
Goldpool
INSPIRATION
Masacre: +250 Critical Rating while the Opponent is suffering from a Bleed debuff (or Shbleeding!).

Deadpool: +250 Critical Rating while the Opponent is suffering from a Bleed debuff (or Shbleeding!).

Deadpool (X-Force): +250 Critical Rating while the Opponent is suffering from a Bleed debuff (or Shbleeding!).

Goldpool: +250 Critical Rating while the Opponent is suffering from a Bleed debuff (or Shbleeding!).
Unique Synergy: Does not stack with duplicate synergies.
Sandman
Green Goblin
Venom
INTERESTED?
Sandman: Sandman’s Petrify Debuffs gain 2% potency.

Green Goblin: Power Drain effects from Green Goblin’s Bag of Tricks also deal a burst of 20% Energy Damage.

Venom: Each hit of Special Attack 1 gains an additional 10% chance to steal a Buff and feed it to the Symbiote.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Gwen
Spider Man (Stark Enhanced)
Spider-Man (Stealth-Suit)
Spider-Man (Supreme)
Spider Man 2099
INTO THE SPIDER VERSE
Spider-Gwen: Enervate duration from Special 1 lasts 1.75 second(s) longer.

Spider Man (Stark Enhanced): Reduces the EMP Webshot cooldown by 7.5 second(s).

Spider-Man (Stealth-Suit): Evading or Dodging Purifies 1 Debuff.

Spider-Man (Supreme): Buffs granted by Blessing of the Web have a 25% chance to trigger twice.

Spider Man 2099: Debuff Pause duration increases by 3 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Carnage
Electro
Kraven
Spider-Man (Supreme)
Vulture
INTO THE VILLAIN VERSE
Carnage: Increase the Permanent Mutation Buffs' max stack to 8.

Electro: When attacking, 20% chance to inflict a Shock Passive on himself and the Opponent, dealing 30% of Attack as Energy Damage over 10 second(s).

Kraven: When a trap activates, inflict an Infuriate Debuff on the Opponent for 4 second(s), causing them to become more aggressive and reducing their Offensive Ability Accuracy by 25%.

Spider-Man (Supreme): Blessing of the Spider Totem also grants [1000, 1400, 1500] Critical Rating.

Vulture: Basic Attacks have 25% chance to grant +10 Chitauri Charges.
Unique Synergy: Does not stack with duplicate synergies.
Baron Zemo
Doctor Doom
Apocalypse
Doctor Octopus
INVASION OF THE BODY SNATCHERS
Synergy Members: Gain +300 Critical Rating when fighting Skill or Cosmic Opponents, +300 Block Proficiency when fighting Science or Tech Opponents, and +30% Regeneration Rate when fighting Mystic or Mutant Opponents. Gain all bonuses when fighting Superior Opponents.
Unique Synergy: Does not stack with duplicate synergies.
Cull Obsidian
Corvus Glaive
Proxima Midnight
INVASIVE FORCE
Cull Obsidian: New Mission: Disarm their Tech: Knockout a Tech Champion. This Mission can only be completed once each Quest.
Solo: Only affects this Champion and does not stack.
Mister Negative
Valkyrie
INVERSION INCURSION
Mister Negative: Converting Light Energy to Dark pauses all Debuffs on the Opponent for 2 second(s).

Valkyrie: Whenever Valkyrie inverts or reverts her Combo Gain, she has a 30% chance to gain a dormant Evade charge.
Unique Synergy: Does not stack with duplicate synergies.
Thanos (Deathless)
She-Hulk (Deathless)
Iron Heel
She-Hulk (Deathless): Gain Immunity to Rupture effects, and the Ability Accuracy of She-Hulk’s personal Debuffs and the Parry Mastery can only be reduced by Skill Champions.
Unique Synergy: Does not stack with duplicate synergies.
Yondu
Beast
Nightcrawler
IT AIN'T EASY
All Champions gain +[250, 325, 400] Block Penetration
Emma Frost
Cyclops (Blue Team)
Cyclops (New Xavier School)
IT'S COMPLICATED
Emma Frost: Emma can strike with Critical Hits even while the Opponent is Blocking.

Cyclops (Blue Team): +10% increased Power Gain.

Cyclops (New Xavier School): +10% increased Power Gain.
Unique Synergy: Does not stack with duplicate synergies.
Black Widow (Deadly Origin)
Phoenix
Cyclops (Blue Team)
Hulk
Hulk (Ragnarok)
Wolverine
IT'S COMPLICATED
All Champions gain +[15, 35, 60] Armor Rating & 3% Power Gain
Cable
Domino
IT'S COMPLICATED
Cable: +15% Armor Rating and +3% Power Gain.

Domino: Start the fight with either Lucky or Unlucky active for 7 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Captain Britain
Black Cat
Domino
Longshot
IT'S GOOD TO BE LUCKY
Captain Britain: Striking an Opponent with a Critical Hit has a 21% chance to grant a non-stacking Precision Buff, increasing Critical Rating by 14% for 7 seconds.

Black Cat: Striking an Opponent with a Critical Hit has a 21% chance to grant a non-stacking Precision Buff, increasing Critical Rating by 14% for 7 seconds.

Domino: Striking an Opponent with a Critical Hit has a 21% chance to grant a non-stacking Precision Buff, increasing Critical Rating by 14% for 7 seconds.

Longshot: Striking an Opponent with a Critical Hit has a 21% chance to grant a non-stacking Precision Buff, increasing Critical Rating by 14% for 7 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Morbius
Punisher
Mole Man
It’s Alive!
Punisher: While Indestructible, hits grant a Regeneration Passive, recovering 2% of Missing Health over 3 seconds. Max 3 stacks.
Synergy Members: +10% Bleed Debuff duration.
Unique Synergy: Does not stack with duplicate synergies.
Hela
Odin
Valkyrie
JAILORS AND THE JAILED
Hela: The first time in the fight Hela is at or below 50% of her Maximum Health, she triggers her personal Physical Resistance Buff.

Odin: When Odin bestows one or more of his Cross-Fight Buffs, the recipient also receives a Bulwark Buff increasing Block Proficiency by 10%, lasting as long as the Cross-Fight Buff.

Valkyrie: Gain +21% Block Proficiency for each other synergy member present.
Unique Synergy: Does not stack with duplicate synergies.
Scorpion
Spider Man (Stark Enhanced)
Spider-Man (Stealth-Suit)
JJJ DEMANDED IT
Scorpion: Gain 15% Perfect Block Chance while Scorpion-Sense is active.

Spider Man (Stark Enhanced): Refreshing a Taunt by Dodging Back and Idling for 1 second also inflicts a Cowardice Debuff on the Opponent reducing Special Attack Damage by 25% for 10 seconds.

Spider-Man (Stealth-Suit): Evading or Dodging an attack also causes Spider-Man’s Web Cartridge Debuffs to be paused for 3.5 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Vox
Black Bolt
Medusa
Karnak
JOIN OR DIE
Vox: For each #Inhuman a Vox has defeated over the course of the Quest, they start each fight with a Corrupted Intensify.
Inhuman Royal Family: For each #Inhuman a Vox has defeated over the course of the Quest, start each fight with an indefinite Fury Buff granting +30% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.