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Iron Fist
Luke Cage
Misty Knight
Shang Chi
Black Cat
Iron Fist (Immortal)
She-Hulk
HEROES FOR HIRE
All Champions gain +[70, 75, 85] Block Proficiency & Physical Resistance.
Cull Obsidian
Hulk
Hulk (Ragnarok)
Hulkbuster
HEROES NEVER LEARN
Cull Obsidian: Launching a Special Attack grants a Fury Buff for 4 seconds, increasing attack by 50%. This Buff gains +150% duration while fighting Hero Champions.
Solo: Only affects this Champion and does not stack.
Ant-Man
Falcon
HI, I'M SCOTT
Ant-Man: Each hit of Special 1 has a 100% chance to Inflict the Opponent with a Fragility Debuff, reducing Block Proficiency by 50% and Increasing Ant-Mans Critical Damage Rating by 235.

Falcon: Increase the Duration of Lockdown by a flat 2 Seconds.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Man (Classic)
Doctor Octopus
HOLDING BACK THIS WHOLE TIME
Spider-Man (Classic): Heavy Attack inflicts a non-stacking Injury Debuff for 13 seconds. Hitting an Injured Opponent bypasses 100% of Physical Resistance.

Doctor Octopus: Gain a 15% chance to Evade attacks for each active Breakthrough. Does not trigger while Blocking.
Unique Synergy: Does not stack with duplicate synergies.
Viv Vision
Mysterio
HOLOGRAMASTERY
Viv Vision: Advanced use of Holograms grants 5% chance to Evade, increased by 2% flat for each active Solar Energy. Does not trigger while Blocking or Phasing.

Mysterio: Illusion Gas' Power Drain potency and chance to cause Miss are increased by 4% flat and 10% flat respectively.
Unique Synergy: Does not stack with duplicate synergies.
Shocker
Spider Man (Stark Enhanced)
Vulture
Silk
HOMECOMING CRASHER
Shocker: Medium Attacks inflict a Shock Debuffs dealing 20% of Attack over 2 seconds.

Spider Man (Stark Enhanced): Medium Attacks inflict a Rupture Debuffs dealing 20% of Attack over 2 seconds.

Vulture: Medium Attacks inflict a 10% Disintegration Debuffs dealing 20% of Attack over 2 seconds.

Silk: Medium Attacks inflict a Rupture Debuffs dealing 20% of Attack over 2 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Titania
Doctor Doom
The Hood
Baron Zemo
HORRIBLE BOSSES
Titania: Debuffs gain +50% Ability Accuracy for each other synergy member present, increased to +100% for each defeated synergy member. Does not affect Debuffs from Titania's Signature Ability.
Solo Synergy: Only affects this Champion and does not stack.
Iron Fist
Super-Skrull
Hostile Takeover
Iron Fist: The first 4 of Iron’s Fist’s personal Armor Break Debuffs start paused. While the opponent is suffering any Armor Break Debuffs the next Buff triggered on them will be immediately Nullified and an Armor Break Debuff is consumed.

Super-Skrull: Each time you activate a Fury Buff there is a 100% Chance to place an Armor Break on the Opponent lasting 4 seconds, reducing Armor by 150. Max Stacks: 5
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Hulkbuster
Iron Man
Iron Man (Infinity War)
War Machine
HOUSE OF IRON
Sorcerer Supreme: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Hulkbuster: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Iron Man: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Iron Man (Infinity War): Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

War Machine: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.
Unique Synergy: Does not stack with duplicate synergies.
Baron Zemo
HOUSE OF ZEMO
Baron Zemo: Gain +50% Bleed potency for each other Baron Zemo on the team. Additionally, gain +5% Bleed potency for each rank in the Deep Wounds Mastery.
Only affects this Champion and does not stack.
Misty Knight
Rocket Raccoon
Winter Soldier
HOW MUCH FOR THE ARMS?
Misty Knight: Whenever Misty would gain 2 Anti-Metal or Cryogenic Charges, she gains 3 instead.

Rocket Raccoon: When Rocket inflicts Armor Break using his Heavy Attack, he gains an Armor Up Buff increasing Armor Rating by 400 for 10 seconds. Max: 5.

Winter Soldier: Activating a Special grants a Precision Buff increasing Critical Rating by 400 for 5 seconds. While it is active, Bucky's Personal Abilities gain a flat +10% chance to trigger.
Unique Synergy: Does not stack with duplicate synergies.
Cassie Lang
Sentinel
HOW'S THE WEATHER DOWN THERE?
All Champions: Gain +5% Attack Rating for each #Size:XL Champion on the team.
Corvus Glaive
Wolverine
Wolverine (X 23)
Storm
HUNT THE UNCANNY
Corvus Glaive: Knockout a Mutant Champion. Once this mission is complete, Corvus receives Safeguard against the opponent’s Special 2 Attack if Glaive’s Immunity is active, preventing him from losing more 5% Health from a single hit.

Wolverine: +10% Attack Rating at the start of the fight.

Wolverine (X 23): +10% Attack Rating at the start of the fight.

Storm: +10% Attack Rating at the start of the fight.
Unique Synergy: Does not stack with duplicate Synergies.
Darkhawk
Elsa Bloodstone
HUNTING PARTY
Darkhawk: Darkhawk instantly charges 50% of a bar of Power when entering a mode from a different mode.

Elsa Bloodstone: When fighting Villains, Elsa gains the effects of the level 1 Assassin Mastery. If the Assassin Mastery is already acquired, it instead activates when the Opponent is below 25% of their Maximum Health.
Unique Synergy: Does not stack with duplicate Synergies.
Elsa Bloodstone
Jabari Panther
Tigra
HUNTRESSES
Elsa Bloodstone: While Reloading, inflict a Disorient Debuff, reducing Defensive Ability Accuracy and Block Proficiency by 50%.

Jabari Panther: Gain a Huntress Charge when Intercepting the Opponent.

Tigra: Unblockable hits Nullify 1 Buff from the Opponent.
Unique Synergy: Does not stack with duplicate synergies.
Angela
Gamora
Guillotine
HUNTRESSES OF THE CONTEST
Angela: +15% Fury and Precision Buff Potency.

Gamora: +20% Attack Rating if at least 30 seconds have passed during the fight.

Guillotine: Gain 2 Soul Charge(s) each time the opponent is Immune to a Bleed.
All Synergy Champions: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Woman
Arnim Zola
Red Skull
Crossbones
Hydra Rebel
Spider-Woman: Against Mystic Champions, gaining a Buff inflicts a 50% Concussion Passive for 0.5 seconds which cannot affect Nodes. While in a fight, count as #Hydra and a #Villain instead of a #Hero.

Arnim Zola: The final hit of Special Attack 1 inflicts a Root Debuff for 3 seconds.

Red Skull: On a Well-Timed Block, 25% chance to not lose an Armor Up Buff.

Crossbones: While Overrun is on cooldown, Intercepts trigger Crossbones’ Fury pause ability.
Unique Synergy: Does not stack with duplicate synergies.
Crossbones
Punisher 2099
Red Skull
HYDRA RECRUITERS
Crossbones: [Contempt] Gain Immunity to Nullify & Stagger.
Mercenary & Villain Champions: +5% Health & +400 Critical Damage Rating.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Doom
I ANSWER TO NO ONE
Doctor Doom: Attack Rating is increased by 10% for each knocked out team member.
Solo: Only affects this Champion and does not stack.
Spider-Punk
Spider man (Miles Morales)
Jessica Jones
Spot
I don’t believe in…
Science Champions: Gain unique abilities depending on who is on the team.
Teams: If Spider-Man (Miles Morales) is on the team, gain +5% Attack Rating for each #Spider-Verse Heroes Champion on the team.
Consistency: If Jessica Jones is on the team, the final hit of Special Attacks randomly inflicts a 200 potency Physical Vulnerability, Energy Vulnerability, Exhaustion, or Fatigue Debuff for 8 seconds.
Comedy: If Spot is on the team, whenever a Buff fails due to Buff Immunity, gain a 10 second Setup Timer. When this timer expires, gain an indefinite Punchline Buff that does nothing. This timer cannot retrigger while active.
Unique Synergy: Does not stack with duplicate synergies.