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The Overseer
Hulk
Hulk (Immortal)
Hulk (Ragnarok)
Joe Fixit
IDENTITY DISORDER
Synergy Champions: Their scrambled personality makes them immune to reverse controls.
Chee'ilth
Hulk
Hulk (Immortal)
Sasquatch
She-Hulk
If You Don’t Talk, You Won’t Know Them
Chee'ilth: Sister Eagle grants 3 additional Cleanse Passives at the start of each fight. [Gamma]: Gain 8 Cleanse Passives instead.
Synergy Champions: +8% Health.
Unique Synergy: Does not stack with duplicate synergies.
Abomination (Immortal)
King Groot
IMMORTAL KINGS
Abomination (Immortal): Personal Poison and Acid Burn effects gain +15% Potency.

King Groot: While Malice is on Cooldown gain a 25% chance to inflict a Poison Debuff dealing 30% of modified attack over 12 seconds each time a contact attack is landed. Additionally the chance to gain Fury charges during Cooldown is increased by a flat +11%.
Unique Synergy: Does not stack with duplicate synergies.
Abomination (Immortal)
Red Skull
IMMORTAL RULERS
Abomination (Immortal): The Basic Attacks required to trigger a Self-Poison are reduced by 2.

Red Skull: Each Armor-Up Buff grants +5% Attack Rating. Additionally, every 10th Basic Attack triggers 1 personal Armor-Up Buff, these count toward Red Skull’s Armor cap.
Unique Synergy: Does not stack with duplicate synergies.
Hela
Loki
Thor (Ragnarok)
IMMORTAL SOULS
Hela: Nullify effects against Hela have a 35% reduced chance to trigger.

Loki: While they are Cursed, Loki always counts as having more Health than his Opponent.

Thor (Ragnarok): Gains +100% Perfect Block Chance, when Autoblocking.
Unique Synergy Does not stack with duplicate synergies.
Colossus
Emma Frost
IMPENETRABLE HIDE
Colossus: +2% increased Power Gain for each Armor Up Buff.

Emma Frost: Emma switches to Diamond Form when she and the Opponent are in the same bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
Black Cat
Spider-Man (Classic)
Spot
IMPETUOUS YOUTH
Black Cat: Special Attacks gain an additional 15% Critical Rating for each 100 hits in Black Cat's Combo Meter.

Spider-Man (Classic): Gain 100% chance to Evade the first time he is struck each fight.

Spot: When Untouchable starts, inflict a 40% Taunt Debuff for 7 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Scorpion
Toad
IN MY NATURE
Scorpion: On a Heavy Attack inflict a Slow Debuff lasting for 10 second(s). Opponents with Natural Class Advantage cannot be slowed. When the Opponent fails to Evade, Scorpion inflicts a burst of Sting Debuff Damage.

Toad: 30% chance to inflict a non-stacking Disorient Debuff reducing Defensive Ability Accuracy and Block Proficiency by 50% for 8 seconds when a Poison expires.
Unique Synergy: Does not stack with duplicate synergies.
Moondragon
Moon Knight
Dani Moonstar
Silk
IN THE NAME OF THE MOON
Moondragon: When Psionic Transcendence ends, gain 5 Psionic Charges.

Moon Knight: While under 2 Bars of Power, Critical Hits grant 4% of Max Power.

Dani Moonstar: Deal 20% of Base Attack as a burst of Energy Damage each time the Opponent Misses.

Silk: Personal bursts of damage are multiplied by 20% of Silk’s Critical Damage Multiplier.
Unique Synergy: Does not stack with duplicate synergies.
Nick Fury
Black Panther (Civil War)
Black Panther
INCREASED FIREPOWER
All Champions except Nick: If Nick is alive, when the fight starts he grants his teammates a Buff doubling their Critical Rating for 10 seconds. Unique Synergy: Does not stack with duplicate synergies.
Hercules
Hulk (Immortal)
Hulk (Ragnarok)
Hulk
INCREDIBLE SUBSTITUTE
Hercules: Start the fight with +3 Strength.

Hulk (Immortal): While Immortality is on Cooldown, Well-Timed Blocks gain +100% Perfect Block chance.

Hulk (Ragnarok): When Crowd Excitement reaches 100, gain a Fury Buff increasing Attack Rating by +55% and inflict a Weakness Debuff reducing Attack Rating by 30%. These last 15 seconds.

Hulk: +15% Fury effect Potency.
Unique Synergy: Does not stack with duplicate synergies.
Adam Warlock
Thanos
Vision (Age of Ultron)
Vision
INFINITY AVATARS
Adam Warlock: Hits that deal True Damage deal an additional 8% of Base Attack Rating.

Thanos: Hits that deal True Damage deal an additional 8% of Base Attack Rating.

Vision (Age of Ultron): Inflicting a Power Burn deals 35% of Base Attack Rating as a burst of Direct Damage.

Vision: Inflicting a Power Burn deals 35% of Base Attack Rating as a burst of Direct Damage.
Unique Synergy: Does not stack with duplicate synergies.
Black Bolt
Medusa
INHUMAN ROYAL FAMILY
Black Bolt: Provocation generates permanent Buffs instead of temporary Buffs.

Medusa: Living Strands generates up to 6 Fury Buffs.
Inhuman Royal Family:+25% Attack at the start of the fight if Medusa, Black Bolt and Karnak are together in a team.
Unique Synergy: Does not stack with duplicate synergies.
Karnak
Medusa
INHUMAN ROYAL FAMILY
Karnak: Striking into the opponent’s Block reduces their Ability Accuracy by 30% per Focus Charge.

Medusa: Heavy Attacks inflict indefinite Armor Break Debuffs to a max of 4.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
Groot
Rocket Raccoon
The Hood
INSEPARABLE
All Champions gain +[7, 8, 9]% Special 3 Damage
Shocker
Daredevil (Classic)
Doctor Octopus
Mysterio
Rhino
Scorpion
INSIDIOUS
Synergy Champions: Gain +250 Critical Resistance, doubled when fighting #Spider-Verse Heroes.
Unique Synergy: Does not stack with duplicate synergies.
Masacre
Deadpool
Deadpool (X-Force)
Goldpool
INSPIRATION
Masacre: Increase Critical Rating by 250 while the Opponent is Bleeding.

Deadpool: Increase Critical Rating by 250 while the Opponent is Bleeding.

Deadpool (X-Force): Increase Critical Rating by 250 while the Opponent is Bleeding.

Goldpool: Increase Critical Rating by 250 while the Opponent is Bleeding.
Unique Synergy: Does not stack with duplicate synergies.
Sandman
Green Goblin
Venom
INTERESTED?
Sandman: Sandman’s Petrify Debuffs gain 2% potency.

Green Goblin: Power Drain effects from Green Goblin’s Bag of Tricks also deal a burst of 20% Energy Damage.

Venom: Each hit of Special Attack 1 gains an additional 10% chance to steal a Buff and feed it to the Symbiote.
Unique Synergy: Does not stack with duplicate synergies.
Spider-Gwen
Spider Man (Stark Enhanced)
Spider-Man (Stealth-Suit)
Spider-Man (Supreme)
Spider Man 2099
INTO THE SPIDER VERSE
Spider-Gwen: Enervate duration from Special 1 lasts 1.75 second(s) longer.

Spider Man (Stark Enhanced): Reduces the EMP Webshot cooldown by 7.5 second(s).

Spider-Man (Stealth-Suit): Evading or Dodging Purifies 1 Debuff.

Spider-Man (Supreme): Buffs granted by Blessing of the Web have a 25% chance to trigger twice.

Spider Man 2099: Debuff Pause duration increases by 3 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Carnage
Electro
Kraven
Spider-Man (Supreme)
Vulture
INTO THE VILLAIN VERSE
Carnage: Increase the Permanent Mutation Buffs' max stack to 8.

Electro: When attacking, 20% chance to inflict a Shock Passive on himself and the Opponent, dealing 30% of Attack as Energy Damage over 10 second(s).

Kraven: When a trap activates, inflict an Infuriate Debuff on the Opponent for 4 second(s), causing them to become more aggressive and reducing their Offensive Ability Accuracy by 25%.

Spider-Man (Supreme): Blessing of the Spider Totem also grants [1000, 1400, 1500] Critical Rating.

Vulture: Basic Attacks have 25% chance to grant +10 Chitauri Charges.
Unique Synergy: Does not stack with duplicate synergies.