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Titania
Doctor Doom
The Hood
Baron Zemo
HORRIBLE BOSSES
Titania: Debuffs gain +50% Ability Accuracy for each other synergy member present, increased to +100% for each defeated synergy member. Does not affect Debuffs from Titania's Signature Ability.
Solo Synergy: Only affects this Champion and does not stack.
Iron Fist
Super-Skrull
Hostile Takeover
Iron Fist: The first 4 of Iron’s Fist’s personal Armor Break Debuffs start paused. While the opponent is suffering any Armor Break Debuffs the next Buff triggered on them will be immediately Nullified and an Armor Break Debuff is consumed.

Super-Skrull: Each time you activate a Fury Buff there is a 100% Chance to place an Armor Break on the Opponent lasting 4 seconds, reducing Armor by 150. Max Stacks: 5
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Hulkbuster
Iron Man
Iron Man (Infinity War)
War Machine
HOUSE OF IRON
Sorcerer Supreme: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Hulkbuster: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Iron Man: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

Iron Man (Infinity War): Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.

War Machine: Armor Break Debuffs inflicted on the Opponent have 30% increased Potency.
Unique Synergy: Does not stack with duplicate synergies.
Baron Zemo
HOUSE OF ZEMO
Baron Zemo: Gain +50% Bleed potency for each other Baron Zemo on the team. Additionally, gain +5% Bleed potency for each rank in the Deep Wounds Mastery.
Only affects this Champion and does not stack.
Misty Knight
Rocket Raccoon
Winter Soldier
HOW MUCH FOR THE ARMS?
Misty Knight: Whenever Misty would gain 2 Anti-Metal or Cryogenic Charges, she gains 3 instead.

Rocket Raccoon: When Rocket inflicts Armor Break using his Heavy Attack, he gains an Armor Up Buff increasing Armor Rating by 400 for 10 seconds. Max: 5.

Winter Soldier: Activating a Special grants a Precision Buff increasing Critical Rating by 400 for 5 seconds. While it is active, Bucky's Personal Abilities gain a flat +10% chance to trigger.
Unique Synergy: Does not stack with duplicate synergies.
Cassie Lang
Sentinel
HOW'S THE WEATHER DOWN THERE?
All Champions: Gain +5% Attack Rating for each #Size:XL Champion on the team.
Corvus Glaive
Wolverine
Wolverine (X 23)
Storm
HUNT THE UNCANNY
Corvus Glaive: Knockout a Mutant Champion. Once this mission is complete, Corvus receives Safeguard against the opponent’s Special 2 Attack if Glaive’s Immunity is active, preventing him from losing more 5% Health from a single hit.

Wolverine: +10% Attack Rating at the start of the fight.

Wolverine (X 23): +10% Attack Rating at the start of the fight.

Storm: +10% Attack Rating at the start of the fight.
Unique Synergy: Does not stack with duplicate Synergies.
Darkhawk
Elsa Bloodstone
HUNTING PARTY
Darkhawk: Darkhawk instantly charges 50% of a bar of Power when entering a mode from a different mode.

Elsa Bloodstone: When fighting Villains, Elsa gains the effects of the level 1 Assassin Mastery. If the Assassin Mastery is already acquired, it instead activates when the Opponent is below 25% of their Maximum Health.
Unique Synergy: Does not stack with duplicate Synergies.
Elsa Bloodstone
Jabari Panther
Tigra
HUNTRESSES
Elsa Bloodstone: While Reloading, inflict a Disorient Debuff, reducing Defensive Ability Accuracy and Block Proficiency by 50%.

Jabari Panther: Gain a Huntress Charge when Intercepting the Opponent.

Tigra: Unblockable hits Nullify 1 Buff from the Opponent.
Unique Synergy: Does not stack with duplicate synergies.
Angela
Gamora
Guillotine
HUNTRESSES OF THE CONTEST
Angela: +15% Fury and Precision Buff Potency.

Gamora: +20% Attack Rating if at least 30 seconds have passed during the fight.

Guillotine: Gain 2 Soul Charge(s) each time the opponent is Immune to a Bleed.
All Synergy Champions: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Crossbones
Punisher 2099
Red Skull
HYDRA RECRUITERS
Crossbones: [Contempt] Gain Immunity to Nullify & Stagger.
Mercenary & Villain Champions: +5% Health & +400 Critical Damage Rating.
Unique Synergy: Does not stack with duplicate synergies.
Doctor Doom
I ANSWER TO NO ONE
Doctor Doom: Attack Rating is increased by 10% for each knocked out team member.
Solo: Only affects this Champion and does not stack.
Spider-Punk
Spider man (Miles Morales)
Jessica Jones
Spot
I don’t believe in…
Science Champions: Gain unique abilities depending on who is on the team.
Teams: If Spider-Man (Miles Morales) is on the team, gain +5% Attack Rating for each #Spider-Verse Heroes Champion on the team.
Consistency: If Jessica Jones is on the team, the final hit of Special Attacks randomly inflicts a 200 potency Physical Vulnerability, Energy Vulnerability, Exhaustion, or Fatigue Debuff for 8 seconds.
Comedy: If Spot is on the team, whenever a Buff fails due to Buff Immunity, gain a 10 second Setup Timer. When this timer expires, gain an indefinite Punchline Buff that does nothing. This timer cannot retrigger while active.
Unique Synergy: Does not stack with duplicate synergies.
Sandman
Spider Man (Stark Enhanced)
Spider-Man (Stealth-Suit)
I JUST WANT TO GO HOME
Sandman: While the Opponent is Decelerated by Sandman’s Special Attack 2, Sandman cannot Miss.

Spider Man (Stark Enhanced): Increases the EMP Webshot's Power Drain potency by 15%.

Spider-Man (Stealth-Suit): +5% Physical Resistance per unspent Web Cartridge.
Unique Synergy: Does not stack with duplicate synergies.
Iron Man (Infamous)
I KNOW HOW THEY THINK
Iron Man (Infamous): While fighting #Villains, gain +460 Critical Damage Rating for each knocked out team member.
Solo: Only affects this Champion and does not stack.
Captain America (Infinity War)
Hercules
I REQUIRE THY SHIELD
Captain America (Infinity War): Gain +7% Fury Potency.

Hercules: Completing a feat of Strength inflicts an Armor Break Debuff, removing 1 Armor Up Buff and reducing Armor Rating by [50, 70, 100] for 10 seconds.
Unique Synergy: Does not stack with duplicate synergies.
She-Hulk
Titania
I WILL BREAK YOU
She-Hulk: Heavy Attacks deal a burst of Physical Damage equal to 75% of base Attack Rating for each Debuff on the Opponent.

Titania: Start each fight with 10 Fury Passives and Fury effects gain +25% duration.
Unique Synergy: Does not stack with duplicate synergies.
Vision (Age of Ultron)
Vision
Viv Vision
I WILL SAVE HER
Vision (Age of Ultron): +0.5% Attack Rating for each percent of Viv’s missing Health, unless Viv is Knocked Out. Counts highest Health Viv on team

Vision: +0.5% Attack Rating for each percent of Viv’s missing Health, unless Viv is Knocked Out. Counts highest Health Viv on team

Viv Vision: When Vivian doesn’t participate in a fight, her father repairs her. At the start of her next fight she gains a Self-Repair Buff, Regenerating 10% of her Max Health over 20 seconds. This Buff is removed if Viv is Stunned.
Unique Synergy: Does not stack with duplicate synergies.
Emma Frost
Elsa Bloodstone
Kate Bishop
Iceman
Misty Knight
ICE QUEENS
Emma Frost: When an Opponent fails to trigger an Evade due to Coldsnap or reduced Ability Accuracy, inflict a Frostbite Passive for 10 seconds, dealing 50% of Attack as Energy Damage when it expires.

Elsa Bloodstone: When an Opponent fails to trigger an Evade due to Coldsnap or reduced Ability Accuracy, inflict a Frostbite Passive for 10 seconds, dealing 50% of Attack as Energy Damage when it expires.

Kate Bishop: When an Opponent fails to trigger an Evade due to Coldsnap or reduced Ability Accuracy, inflict a Frostbite Passive for 10 seconds, dealing 50% of Attack as Energy Damage when it expires.

Iceman: When an Opponent fails to trigger an Evade due to Coldsnap, inflict a personal Frostbite Passive.

Misty Knight: When an Opponent fails to trigger an Evade due to Coldsnap, inflict a personal Frostbite Passive.
Unique Synergy: Does not stack with duplicate synergies.
Omega Sentinel
Nimrod
IDENTICAL CPUS
Omega Sentinel: Whenever any hit from the Opponent's Special Attacks does not make contact with Omega Sentinel, she inflicts them with a Shock Passive, dealing 15% Energy Damage over 6 seconds.
Solo Synergy: Only affects this Champion and does not stack.