Double (Triple) Agent
Spider-Woman: When Immune to one of her own Fury Buffs, inflict 2 personal Power Stings. If the Signature Ability is active, trigger its chance to gain a Fury Passive. While in a fight, count as a #S.H.I.E.L.D agent.
Nick Fury: Start with 6 Tactical Advantage Charges when fighting a #Villain.
Super-Skrull: Start each fight with an Undermine Buff for 20 seconds, and his personal Undermine lasts 5 seconds longer.
Unique Synergy: Does not stack with duplicate synergies.
DOUBLE NEGATIVE
Annihilus: When Striking an Auto Blocking Opponent, Annihilus gets a Taunt passive for 0.5 seconds.
Darkhawk: Attack Rating increased by 9% while in any mode.
Contingency Plan: If Annihilus is fighting Darkhawk, Darkhawk's Armor Rating is decreased by 15% while in any mode.
DRAG BRUNCH
Loki: Finishing a combo with a light attack pauses Curse for 4 seconds.
Wiccan: Last Hit of Special 2 inflicts a Slow Debuff for 10 second(s).
Unique Synergy: Does not stack with duplicate synergies.
DRESSED FOR A FUNERAL
Agent Venom: When inflicting the Opponent with Bleed, also inflict an Incinerate Debuff, reducing Block Proficiency by 50% and dealing 220% of Attack in Energy Damage over 4 second(s).
Scorpion: Gain a Fury Passive for each Sting Debuff on the Opponent, increasing Attack Rating by 10%.
Venom: Gain 25 Power per Unique Buff over 5 seconds whenever Venom gains a Genetic Memory Buff.
Unique Synergy: Does not stack with duplicate synergies.
DRUG I
Colossus: Start each fight with 1 indefinite Armor Up Buff, granting +15% Armor Rating.
Wolverine: +15% Critical Rating.
Wolverine (X 23): +15% Critical Rating.
All Mutants and X-Men except Professor X: +18% Poison Resistance for each Cerebro Charge. Max 72%.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
DRUG L
Cyclops (New Xavier School): Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.
Cyclops (Blue Team): Beam Hits gain +100% Critical Damage Rating and inflict an Armor Break, reducing Armor Rating by 20% for 5 seconds.
Phoenix: The stack limit for personal Fury Buffs is increased by 3.
All Mutants and X-Men except Professor X: Once per fight when a Champion would be knocked out, immediately regenerate 7.5% of their Max Health for each Cerebro Charge. Max 30% Health.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
DRUG M
Iceman: Inflict 3 personal Frostbite Passives whenever the Opponent Purifies a Coldsnap Debuff.
Magneto (House of X): Guidance's bonus Attack Rating is increased by a flat +5% or +15% on the final node of a Quest.
Magneto: +15% Attack Rating while fighting #Metal Champions.
All Mutants and X-Men except Professor X: Gain a Mental Barrier with 2.5% of Current Health for each Cerebro Charge. Max 10% Health. Whenever the Champion would take damage except from Special 3 Attacks, the Barrier takes 75% of the damage until it reaches 0 Health.
Unique Synergy: Does not stack with duplicate synergies.
Unique Synergy: Does not stack with duplicate synergies.
DRY ICE
Iceman: Increase the duration of Frostbite Passives by 4 second(s) flat.
Mysterio: Increase the duration of Reflection and Frenzy gas by 3 second(s) flat.
Vision (Aarkus): Increase the duration of Armor Break Debuffs by 2 second(s) flat.
Unique Synergy: Does not stack with duplicate synergies.
EASTERN BLOCKERS
Abomination: Attacks have a 50% chance to inflict Poison, dealing 70% of modified Attack over 10 seconds.
Rhino: Starts the fight with a Passive Fury granting +30% Attack Rating for 20 seconds. While this Fury is active Rhino also gains +50% increased Ability Accuracy and inflicts the Opponent with a Slow Debuff.
Unique Synergy: Does not stack with duplicate synergies.
ELDERS’ GAME
Mordo: While charging a Heavy Attack, if the Opponent attacks, Mordo will evade. This ability has a 25 second cooldown.
Red Hulk: When hitting the Opponent with his first Heavy Hit, Red Hulk consumes a Heat Charge and inflicts an Armor Break Debuff, reducing the Opponent’s Armor Rating by 50% for 8 seconds.
Terrax: Gain +15% chance to Armor Break during his Rock Field.
Unique Synergy: Does not stack with duplicate synergies.
ELECTRIC SUPERCHARGE
Electro: While under a Shock Debuff, +30% Attack.
Green Goblin: +20% Bag of Tricks Potency.
Unique Synergy: Does not stack with duplicate synergies.
ELEMENTAL HIDE
Iceman: While Ice Armor is reforming, Iceman’s Attack Rating is increased by 15% as long as he does not get hit.
Korg: If Korg is awakened, +15% chance to shrug off a Debuff while Rock Shield is active.
Unique Synergy: Does not stack with duplicate Synergies.
ENCHANTED BLADES
Guillotine: Once per fight Heimdall will intercede on your behalf, dash back and hold Block for 1.5 seconds to gain an infinite Duration Precision Buff increasing Critical Rate by 250.
Magik: Once per fight Heimdall will intercede on your behalf, dash back and hold Block for 1.5 seconds to gain an infinite Duration Precision Buff increasing Critical Rate by 250.
Unique Synergy: Does not stack with duplicate synergies.
ENCROACHING INSANITY
Mysterio: Poison durations are increased by 2 seconds.
Solo: Only affects this Champion and does not stack.
ENEMIES OF THE MYSTICAL REALM
Dormammu: After Adding 1 Detonation Charge by Heavy Attack, Light attacks have a 30% chance to add 10 Detonation Charges.
Rintrah: Start the Fight with 5 Mystical Charges.
Vision (Aarkus): Increase Coldsnap Debuff damage by 50%.
Unique Synergy: Does not stack with duplicate synergies.
ENEMY OF ALCHEMAX
Scorpion: If Scorpion-Sense is active and Scorpion is Stunned, Scorpion’s Evade Ability Accuracy is increased to 100%.
Spider Man 2099: When Striking the Opponent's Block, each Wither Debuff on the Opponent has 50% chance to inflict an additional Rupture.
Unique Synergy: Does not stack with duplicate synergies.
ENERGY ABSORPTION
Bishop: +25% Regeneration Rate and +30% Prowess potency. Once per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.
Havok: +5% Combat Power Rate and +20% Ability Power Rate. Once per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.
Mangog: Once per fight when struck by an energy attack inflict the Opponent with a Stun Debuff for 1.2 seconds.
Unique Synergy: Does not stack with duplicate synergies.
ENERGY CONDUIT - Cyclops
Bishop: Start the fight with +[1, 2] Prowess and +1 Bar of Power.
Cyclops (Blue Team): +[10, 15]% Energy Resistance.
Cyclops (New Xavier School): +[10, 15]% Energy Resistance.
ENERGY CONDUIT - Doctor Strange
Bishop: Start the fight with +[1, 2] Prowess and +1 Bar of Power.
Doctor Strange: +[10, 15]% Energy Resistance.
ENERGY CONDUIT - Electro
Bishop: Start the fight with +[1, 2] Prowess and +1 Bar of Power.
Electro: +[10, 15]% Energy Resistance.