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Scarlet Witch (Sigil)
Cyclops (New Xavier School)
Emma Frost
Storm
Wolverine
Decimation
Scarlet Witch (Sigil): Copied Buffs have 25% increased duration.
All Champions: Mutant Opponents have 30% reduced Ability Accuracy during either Champions Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.
Sabretooth
Magneto
Magneto (House of X)
Scarlet Witch (Classic)
DECIMATION
Sabretooth: Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto: Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto (House of X): Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Scarlet Witch (Classic): Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Elektra
Kingpin
Iron Fist
Iron Fist (Immortal)
Luke Cage
DEFENDERS DESTROYER
Elektra: +25% Bleed Ability Accuracy & duration.

Kingpin: Enter the fight with 2 Rage.

Iron Fist: +25% Armor Break duration and Potency.

Iron Fist (Immortal): +25% Armor Break duration and Potency.

Luke Cage: Up to +60% Attack Rating based on Physical Resistance.
Unique Synergy: Does not stack with duplicate synergies.
Gorr
Thor
Thor (Ragnarok)
Thor (Jane Foster)
DEICIDE
Gorr: Shadow Magic Buff duration increased by 2 second(s).
Solo Synergy: Only affects this Champion and does not stack.
Blade
Mephisto
Dormammu
DEMON HUNTER
Blade: Danger Sense bonuses expand to include all Mystic Champions. Danger Sense's Ability Accuracy reduction does not ignore the Immunities from Mystic Champions.

Mephisto: Opponent's Energy Resistance is reduced by -950.

Dormammu: Opponent's Energy Resistance is reduced by -950.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
Mephisto
Scarlet Witch (Sigil)
Demonic Pact
Dormammu: Imbued Attacks have 1250 increased Attack Rating.

Mephisto: While the Opponents Soul is Imprisoned, 100% chance to activate Aura of Incinerate when the Opponent fails to gain a Buff through Chance. Cooldown 1 second.

Scarlet Witch (Sigil): Chaos Surge creates Regeneration instead of Prowess, granting 4% of missing health over 12 seconds. Prowess can no longer be copied, but Regeneration can.
Dimensional Beings: +15% increased Ability Power Rate.
Unique Synergy: Does not stack with duplicate Synergies.
Mephisto
Dormammu
DEMONS
Mephisto: +80% Energy Resistance while taking Damage over time.

Dormammu: +80% Energy Resistance while taking Damage over time.
Unique Synergy: Does not stack with duplicate synergies.
Bullseye
Deadpool
Deadpool (X-Force)
Did We Just Become Best Friends
Bullseye: Block Penetration increases by 5% for each personal Cruelty Passive.

Deadpool: Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Deadpool (X-Force): Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.
Unique Synergy: Does not stack with duplicate synergies.
Omega Sentinel
Omega Red
DIFFERENT BUT THE SAME
Omega Sentinel: For each Armor Up consumed during a Special Attack, inflict an Armor Break Debuff reducing Armor Rating by 10% for the duration of that Special Attack.
Solo Synergy: Only affects this Champion and does not stack.
Purgatory
Dormammu
Magik
Mephisto
The Hood
DIMENSIONAL BUDDIES
#DimensionalBeings: Gain Bleed Immunity, 20% increased Ability Accuracy, and +900 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.
Ant-Man
Psycho-Man
Wasp
Yellow Jacket
DINKY SHRINKS
Ant-Man: Special Attack 1 inflicts the Opponent with 2 Stagger Debuffs for 12 second(s).

Psycho-Man: Heavy Attacks grant a non-stacking Armor Up Buff, increasing Armor Rating by +600 for 10 second(s).

Wasp: +1200 Block Proficiency.

Yellow Jacket: When the Opponent fills a Bar of Power, they gain a Power Sting Debuff for 8 seconds, dealing 30% of Yellowjacket's Attack as Direct Damage.
Unique Synergy: Does not stack with duplicate synergies.
Kindred
Silk
Spider man (Miles Morales)
Spider-Man (Classic)
DINNER PARTY
Kindred: +10% Degeneration effect potency
Solo Synergy: Only affects this Champion and does not stack.
Dazzler
Human Torch
Masacre
Omega Sentinel
Phoenix
Sunspot
Disco Inferno
Dazzler: Performing a Dazzling Dash inflicts an Incinerate Debuff dealing 20% of Attack as Energy Damage over 10 seconds.
Other Synergy Champions: Incinerate and Plasma Debuffs gain 15% duration.
Unique Synergy: Does not stack with duplicate synergies.
Cull Obsidian
Ebony Maw
Thanos
DISPLAY OF STRENGTH
Cull Obsidian: New Mission: Show your Might: Knockout a Champion while the Rout Buff is active. This mission can only be completed once each Quest.
Solo: Only affects this Champion and does not stack.
Titania
Colossus
Drax
Hulk
Hyperion
DO YOU EVEN LIFT?
Titania: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Colossus: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Drax: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hulk: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hyperion: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.
Doctor Strange
Iron Man (Infamous)
DOCTOR DESPOTS
Doctor Strange: Heavy Attacks refresh all existing Blessings, and all effects of Special 1 are increased by a flat 100% for each active Blessing.

Iron Man (Infamous): Cowardice effects on the Opponent are 50% more potent.
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Doctor Strange
Symbiote Supreme
DOCTORS STRANGE
Sorcerer Supreme: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Doctor Strange: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Symbiote Supreme: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.
Unique Synergy: Does not stack with duplicate synergies.
America Chavez
Kate Bishop
DON'T CALL ME PRINCESS
America Chavez: Reduce the duration of the Opponent’s Indestructible and Regeneration Buffs by 40% for each unique Parallel Dimension.

Kate Bishop: The max stack limit of all Trick Arrows is increased by 1.
Unique Synergy: Does not stack with duplicate synergies.
Hulk (Ragnarok)
Hulk
Hulkbuster
DON'T MENTION PUNY BANNER!
Hulk (Ragnarok): Gains up to +1000 Physical Resistance based on how high the Crowd Meter is.

Hulk: Immunity to Nullify, Fate Seal and Stagger.

Hulkbuster: Up to +1000 Armor Rating based on how low Hulkbuster’s current Health is.
Unique Synergy: Does not stack with duplicate Synergies.
Shocker
Punisher
Spider-Man (Classic)
DON'T MOCK THE SHOCKER!
Shocker: At 50+ Vibro-Shock Charges, Defenders are 50% more likely to activate Special Attacks.
Solo Synergy: Only affects this Champion and does not stack.