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Dormammu
The Hood
Mordo
DARK EMPOWERMENT
Non-Robot Villain champions have a 20% chance to Revive at 10% Health when receiving a knock out blow
Red Skull
Iron Patriot
Kingpin
Loki
M.O.D.O.K.
DARK ILLUMINATI
All Villains gain +20% Armor.
Unique Synergy: Does not stack with duplicate synergies.
Darkhawk
Venom
Punisher
Ghost Rider
DARK JUSTICE
Darkhawk: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Venom: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Punisher: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Ghost Rider: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.
Unique Synergy: Does not stack with duplicate synergies.
Kingpin
Mister Negative
Spot
DARKFORCE PROJECT FUNDING
Kingpin: Start each fight with +1 Rage Debuff.

Mister Negative: Activating a Special Attack immediately after a Basic Attack lands inflicts an 8% Fatigue Debuff for 8 seconds.

Spot: Start each fight with 2 Spots.
Unique Synergy: Does not stack with duplicate synergies.
Knull
Sentry
Void
The Hood
DARKNESS INSIDE YOU
Knull: While the opponent is suffering from 12+ Armor Breaks, Knull gains an indefinite Energize Buff.
Solo: Only affects this Champion and does not stack.
Ægon
The Champion
DAVID AND GOLIATH
Ægon: Ægon gets +20% Attack Rating while fighting larger Champions.

The Champion: The Champion gets +20% Attack Rating while fighting smaller Champions
Unique Synergy: Does not stack with duplicate synergies.
Guillotine (Deathless)
Guillotine 2099
Guillotine
Morningstar
Purgatory
Deadless Enemies
Synergy Champions: For each Synergy Champion present, gain 40 Critical Rating and 2% Ability Power Rate.
Unique Synergy: Does not stack with duplicate synergies.
Ant-Man (Future)
Odin
Ultron
DEADLIEST MENACE OF YESTERDAY
Ant-Man (Future): Incoming Shock effects suffer -60% duration.

Odin: When inflicted with a Shock effect, gain an indefinite Shock Resist Buff, increasing Shock Resistance by 50%.

Ultron: +30% Bleed and Degeneration Debuff duration.
Unique Synergy: Does not stack with duplicate synergies.
Mephisto
Omega Red
Void
DEADLY PRESENCE
Mephisto: The Aura of Incineration deals 15% more damage.

Omega Red: The Death Field deals 10% more damage.

Void: Intimidating Presence debuffs deal 10% more damage.
Unique Synergy: Does not stack with duplicate synergies.
Wasp
Yellow Jacket
DEADLY STING
Wasp: When she intercepts the opponent’s Dash Attack and Concussion is not active on the opponent, Concussion is inflicted, reducing the opponent’s Ability Accuracy by 100% for 8 seconds. This can activate 3 times in a fight.

Yellow Jacket: 40% chance to reactivate a Power Sting when it’s timer expires.
Unique Synergy: Does not stack with duplicate Synergies.
Squirrel Girl
Deadpool
DEADPOOL'S GUIDE TO SUPER VILLAINS
Squirrel Girl: Squirrel Girl reads Deadpool’s Guide to Super Villains cards to gain an advantage, increasing her Attack Rating by 10% while fighting Villain Champions.
Solo: Only affects this Champion and does not stack.
Jubilee
Doctor Octopus
Falcon
Hawkeye
Hit-Monkey
DEAL WITH IT
Synergy Members: +10% Max Health.
Unique Synergy: Does not stack with duplicate synergies.
QuickSilver
Scarlet Witch (Classic)
Scarlet Witch (Sigil)
DEAR SISTER
QuickSilver: The first Special Attack after reaching Max Momentum Charges has its Attack Power increased by 70%.

Scarlet Witch (Classic): When Veil of Fortune Triggers, 50% chance to gain a Prowess Buff, granting 100% Special Attack Damage for 15 second(s).

Scarlet Witch (Sigil): When gaining one Instability Gain a Prowess Buff, granting 50% Special Attack Damage for 15 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Phoenix
Terrax
DEATH AND RESURRECTION
Phoenix: The durations of the Buffs granted by Rite of the Phoenix are increased by 50%.

Terrax: Well-timed blocks give Terrax +3% of a Bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
Gorr
Mangog
DEATH TO VALHALLA
Gorr: While the Opponent is inflicted with at least 15 damaging Debuffs, gain an indefinite True Damage Buff.

Mangog: While Enrage is active, the burst of Energy Damage from Heavy Attack charges twice as fast.
Unique Synergy: Does not stack with duplicate synergies.
She-Hulk (Deathless)
Thanos (Deathless)
Deathless Arbiter
She-Hulk (Deathless): Intercepting the Opponent inflicts a personal Trauma Debuff. Cooldown: 5 seconds.

Thanos (Deathless): Intercepting the Opponent inflicts an Instant Corrosion dealing 20% of Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Guillotine (Deathless)
Thanos (Deathless)
Deathless Harvester
Guillotine (Deathless): The amount of Max Health required to gain a new Soul is decreased by 2%.

Thanos (Deathless): For each personal Debuff on the Opponent, gain +200 Critical Damage Rating.
Unique Synergy: Does not stack with duplicate synergies.
Vision (Deathless)
Thanos (Deathless)
Deathless Processor
Vision (Deathless): Upon triggering an Immunity, Burn 50% of a Bar of Power from the Opponent. If this reduces the Opponent’s Power below any full Bar, gain a Phase Charge. This ability has a 12 second cooldown.

Thanos (Deathless): Gain Immunity to Power Burn and Power Drain effects.
Unique Synergy: Does not stack with duplicate synergies.
King Groot (Deathless)
Thanos (Deathless)
Deathless Reaper
King Groot (Deathless): Gain an Undermine Buff during Special Attacks.

Thanos (Deathless): Personal Genesis Passives gain 30% increased duration.
Unique Synergy: Does not stack with duplicate synergies.
Platinum Pool
Doctor Doom
DEATHWISH
Platinum Pool: Increase the chance to draw the Sumopool Card.
Solo: Only affects this Champion and does not stack.