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QuickSilver
Scarlet Witch (Classic)
Scarlet Witch (Sigil)
DEAR SISTER
QuickSilver: The first Special Attack after reaching Max Momentum Charges has its Attack Power increased by 70%.

Scarlet Witch (Classic): When Veil of Fortune Triggers, 50% chance to gain a Prowess Buff, granting 100% Special Attack Damage for 15 second(s).

Scarlet Witch (Sigil): When gaining one Instability Gain a Prowess Buff, granting 50% Special Attack Damage for 15 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Phoenix
Terrax
DEATH AND RESURRECTION
Phoenix: When striking with her fourth Light Attack, Phoenix consumes one of her personal Fury Buffs, increasing the hit damage by 100%.

Terrax: Well-timed blocks give Terrax +3% of a Bar of Power.
Unique Synergy: Does not stack with duplicate synergies.
Gorr
Mangog
DEATH TO VALHALLA
Gorr: While the Opponent is inflicted with at least 15 damaging Debuffs, gain an indefinite True Damage Buff.

Mangog: While Enrage is active, the burst of Energy Damage from Heavy Attack charges twice as fast.
Unique Synergy: Does not stack with duplicate synergies.
Platinum Pool
Doctor Doom
DEATHWISH
Platinum Pool: Increase the chance to draw the Sumopool Card.
Solo: Only affects this Champion and does not stack.
Scarlet Witch (Sigil)
Cyclops (New Xavier School)
Emma Frost
Storm
Wolverine
Decimation
Scarlet Witch (Sigil): Copied Buffs have 25% increased duration.
All Champions: Mutant Opponents have 30% reduced Ability Accuracy during either Champions Special Attacks.
Unique Synergy: Does not stack with duplicate Synergies.
Sabretooth
Magneto
Magneto (House of X)
Scarlet Witch (Classic)
DECIMATION
Sabretooth: Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto: Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Magneto (House of X): Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.

Scarlet Witch (Classic): Starts the fight with a Fury Buff against Mutant Champions, granting +15% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Elektra
Kingpin
Iron Fist
Iron Fist (Immortal)
Luke Cage
DEFENDERS DESTROYER
Elektra: +25% Bleed Ability Accuracy & duration.

Kingpin: Enter the fight with 2 Rage.

Iron Fist: +25% Armor Break duration and Potency.

Iron Fist (Immortal): +25% Armor Break duration and Potency.

Luke Cage: Up to +60% Attack Rating based on Physical Resistance.
Unique Synergy: Does not stack with duplicate synergies.
Gorr
Thor
Thor (Ragnarok)
Thor (Jane Foster)
DEICIDE
Gorr: Shadow Magic Buff duration increased by 2 second(s).
Solo Synergy: Only affects this Champion and does not stack.
Blade
Mephisto
Dormammu
DEMON HUNTER
Blade: Danger Sense bonuses expand to include all Mystic Champions. Danger Sense's Ability Accuracy reduction does not ignore the Immunities from Mystic Champions.

Mephisto: Opponent's Energy Resistance is reduced by -950.

Dormammu: Opponent's Energy Resistance is reduced by -950.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
Mephisto
Scarlet Witch (Sigil)
Demonic Pact
Dormammu: Imbued Attacks have 1250 increased Attack Rating.

Mephisto: While the Opponents Soul is Imprisoned, 100% chance to activate Aura of Incinerate when the Opponent fails to gain a Buff through Chance. Cooldown 1 second.

Scarlet Witch (Sigil): Chaos Surge creates Regeneration instead of Prowess, granting 4% of missing health over 12 seconds. Prowess can no longer be copied, but Regeneration can.
Dimensional Beings: +15% increased Ability Power Rate.
Unique Synergy: Does not stack with duplicate Synergies.
Mephisto
Dormammu
DEMONS
Mephisto: +80% Energy Resistance while taking Damage over time.

Dormammu: +80% Energy Resistance while taking Damage over time.
Unique Synergy: Does not stack with duplicate synergies.
Bullseye
Deadpool
Deadpool (X-Force)
Did We Just Become Best Friends
Bullseye: Block Penetration increases by 5% for each personal Cruelty Passive.

Deadpool: Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.

Deadpool (X-Force): Start each fight with an indefinite Meat Armor Buff granting 20% Armor Rating and 10% Block Proficiency. This Buff is removed if Deadpool is struck by a projectile, or inflicted with Bleed.
Unique Synergy: Does not stack with duplicate synergies.
Omega Sentinel
Omega Red
DIFFERENT BUT THE SAME
Omega Sentinel: For each Armor Up consumed during a Special Attack, inflict an Armor Break Debuff reducing Armor Rating by 10% for the duration of that Special Attack.
Solo Synergy: Only affects this Champion and does not stack.
Purgatory
Dormammu
Magik
Mephisto
The Hood
DIMENSIONAL BUDDIES
#DimensionalBeings: Gain Bleed Immunity, 20% Ability Accuracy, and +900 Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.
Ant-Man
Psycho-Man
Wasp
Yellow Jacket
DINKY SHRINKS
Ant-Man: Special Attack 1 inflicts the Opponent with 2 Stagger Debuffs for 12 second(s).

Psycho-Man: Heavy Attacks grant a non-stacking Armor Up Buff, increasing Armor Rating by +600 for 10 second(s).

Wasp: +1200 Block Proficiency.

Yellow Jacket: When the Opponent fills a Bar of Power, they gain a Power Sting Debuff for 8 seconds, dealing 30% of Yellowjacket's Attack as Direct Damage.
Unique Synergy: Does not stack with duplicate synergies.
Kindred
Silk
Spider man (Miles Morales)
Spider-Man (Classic)
DINNER PARTY
Kindred: +10% Degeneration effect potency
Solo Synergy: Only affects this Champion and does not stack.
Cull Obsidian
Ebony Maw
Thanos
DISPLAY OF STRENGTH
Cull Obsidian: New Mission: Show your Might: Knockout a Champion while the Rout Buff is active. This mission can only be completed once each Quest.
Solo: Only affects this Champion and does not stack.
Titania
Colossus
Drax
Hulk
Hyperion
DO YOU EVEN LIFT?
Titania: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Colossus: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Drax: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hulk: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.

Hyperion: Increase the potency of Fury effects by 4% for each synergy member present. Max: 20%.
Doctor Strange
Iron Man (Infamous)
DOCTOR DESPOTS
Doctor Strange: Heavy Attacks refresh all existing Blessings, and all effects of Special 1 are increased by a flat 100% for each active Blessing.

Iron Man (Infamous): Cowardice effects on the Opponent are 50% more potent.
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Doctor Strange
Symbiote Supreme
DOCTORS STRANGE
Sorcerer Supreme: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Doctor Strange: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.

Symbiote Supreme: Gain Passive Prowess whenever a Blessing activates, increasing Special Attack damage by 15%. These last until the end of the Synergy Member's next Special Attack, and are capped at 3.
Unique Synergy: Does not stack with duplicate synergies.