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Enchantress
Valkyrie
Crystalline Prison
Enchantress: New Transmutation Spell: Shield: ↓ , ↓ , ↓. Grants a Bulwark buff.

Valkyrie: While her Combo is inverted, Valkyrie’s Block Proficiency is increased by +1200.
Red Skull
Thanos
The Overseer
CUBE WIELDERS
Red Skull: 8% chance per Armor Up to inflict an Armor Break Debuff on Special 2 attacks, reducing Armor Rating by [525, 562] for 15 second(s).

Thanos: Fury also grants a Power Gain Buff, gaining half of a bar of Power over 7 second(s).

The Overseer: 50% chance to gain an Indefinite Gamma Power when the Opponent launches a Special while Taunted.
Unique Synergy: Does not stack with duplicate synergies.
Abomination
M.O.D.O.K.
CUBICLE MATES
Abomination: Deal 50% more Poison Damage.

M.O.D.O.K.: Take 50% less Poison Damage.
Unique Synergy: Does not stack with duplicate synergies.
Cull Obsidian
Ebony Maw
CULL OF THE MAW
Cull Obsidian: When 1 or more Thanos’ Favor Buffs expire, gain a Fury Buff granting 10% attack for 10 seconds. Fury Buffs gained in this way will not stack.

Ebony Maw: Charging a Heavy Attack for 0.5 seconds grants the Opponent an indefinite Fury Buff, increasing their Attack Rating by 0%.
Unique Synergy: Does not stack with duplicate synergies.
Electro
Spider Man (Stark Enhanced)
CULTURE SHOCK
Electro: When one of Electro’s Stun abilities fail to trigger, he inflicts a Shock Debuff instead dealing 40% of Attack over 7 seconds.

Spider Man (Stark Enhanced): Increases the potency of Fury, and Precision effects that trigger while Spider-Sense is active by 15%.
Unique Synergy: Does not stack with duplicate synergies.
Gamora
Black Panther (Civil War)
Mister Fantastic
CYBERNETICS UPGRADE - ASSAULT
Gamora: +20% Fury & Cruelty Buff Potency.

Black Panther (Civil War): +5% Attack Rating.

Mister Fantastic: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Gamora
Guillotine 2099
Silver Centurion
CYBERNETICS UPGRADE - BLITZ
Gamora: Personal Buffs gain +20% duration. Begin the fight with 1 Fury and 1 Cruelty Buff.

Guillotine 2099: +5% Attack Rating.

Silver Centurion: +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Gamora
Beast
Iron Man (Infinity War)
CYBERNETICS UPGRADE - TACTICS
Gamora: Godslayer Strike recharges 20% faster. Additionally, gain +20% Attack Rating during Special Attacks.

Beast: +5% Attack Rating.

Iron Man (Infinity War): +5% Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Dormammu
The Hood
Mordo
DARK EMPOWERMENT
Non-Robot Villain champions have a 20% chance to Revive at 10% Health when receiving a knock out blow
Red Skull
Iron Patriot
Kingpin
Loki
M.O.D.O.K.
DARK ILLUMINATI
All Villains gain +20% Armor.
Unique Synergy: Does not stack with duplicate synergies.
Darkhawk
Venom
Punisher
Ghost Rider
DARK JUSTICE
Darkhawk: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Venom: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Punisher: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.

Ghost Rider: + 30% Power Rate against Villains. +10% Critical Rating against Heroes.
Unique Synergy: Does not stack with duplicate synergies.
Kingpin
Mister Negative
Spot
DARKFORCE PROJECT FUNDING
Kingpin: Start each fight with +1 Rage Debuff.

Mister Negative: Activating a Special Attack immediately after a Basic Attack lands inflicts an 8% Fatigue Debuff for 8 seconds.

Spot: Start each fight with 2 Spots.
Unique Synergy: Does not stack with duplicate synergies.
Knull
Sentry
Void
The Hood
DARKNESS INSIDE YOU
Knull: While the opponent is suffering from 12+ Armor Breaks, Knull gains an indefinite Energize Buff.
Solo: Only affects this Champion and does not stack.
Ægon
The Champion
DAVID AND GOLIATH
Ægon: Ægon gets +20% Attack Rating while fighting larger Champions.

The Champion: The Champion gets +20% Attack Rating while fighting smaller Champions
Unique Synergy: Does not stack with duplicate synergies.
Guillotine (Deathless)
Guillotine 2099
Guillotine
Morningstar
Purgatory
Deadless Enemies
Synergy Champions: For each Synergy Champion present, gain 40 Critical Rating and 2% Ability Power Rate.
Unique Synergy: Does not stack with duplicate synergies.
Ant-Man (Future)
Odin
Ultron
DEADLIEST MENACE OF YESTERDAY
Ant-Man (Future): Incoming Shock effects suffer -60% duration.

Odin: When inflicted with a Shock effect, gain an indefinite Shock Resist Buff, increasing Shock Resistance by 50%.

Ultron: +30% Bleed and Degeneration Debuff duration.
Unique Synergy: Does not stack with duplicate synergies.
Mephisto
Omega Red
Void
DEADLY PRESENCE
Mephisto: The Aura of Incineration deals 15% more damage.

Omega Red: The Death Field deals 10% more damage.

Void: Intimidating Presence debuffs deal 10% more damage.
Unique Synergy: Does not stack with duplicate synergies.
Wasp
Yellow Jacket
DEADLY STING
Wasp: When she intercepts the opponent’s Dash Attack and Concussion is not active on the opponent, Concussion is inflicted, reducing the opponent’s Ability Accuracy by 100% for 8 seconds. This can activate 3 times in a fight.

Yellow Jacket: 40% chance to reactivate a Power Sting when it’s timer expires.
Unique Synergy: Does not stack with duplicate Synergies.
Squirrel Girl
Deadpool
DEADPOOL'S GUIDE TO SUPER VILLAINS
Squirrel Girl: Squirrel Girl reads Deadpool’s Guide to Super Villains cards to gain an advantage, increasing her Attack Rating by 10% while fighting Villain Champions.
Solo: Only affects this Champion and does not stack.
Jubilee
Doctor Octopus
Falcon
Hawkeye
Hit-Monkey
DEAL WITH IT
Synergy Members: +10% Max Health.
Unique Synergy: Does not stack with duplicate synergies.