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Silver Sable
Spider-Man (Classic)
Frenemies
Silver Sable: Decrease the cooldown on Sable Mines by 2 seconds.

Spider-Man (Classic): While at 5+ Webbing, inflict an indefinite Shock Debuff dealing 60% of Attack as Energy Damage per second.
Unique Synergy: Does not stack with duplicate synergies.
Attuma
Invisible Woman
Phoenix
Wasp
FREQUENT KIDNAPPER MILES
Attuma: Power gained from the Opponent Evading is increased by a flat 15%.

Invisible Woman: Landing a Heavy Attack while Invisibility is unpaused repauses it.

Phoenix: Heavy Attacks have a 25% chance to grant a Phoenix Force charge.

Wasp: +10% flat chance to trigger personal Purify for each Debuff on her.
Unique Synergy: Does not stack with duplicate synergies.
Thor (Ragnarok)
Hulk
Hulk (Ragnarok)
Hulk (Immortal)
The Overseer
FRIEND FROM WORK
Thor (Ragnarok): +15% Attack while Thunder God’s Wrath is active.

Hulk: When brought below 20% Max Health, gain an Indestructible Passive lasting 5 seconds.

Hulk (Ragnarok): When brought below 20% Max Health, gain an Indestructible Passive lasting 5 seconds.

Hulk (Immortal): When brought below 20% Max Health, gain an Indestructible Passive lasting 5 seconds.

The Overseer: When brought below 20% Max Health, gain an Indestructible Passive lasting 5 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Ægon
Sentry
FRIENDS
Ægon: Well-Timed Blocks guarantee Ægon's next hit will be a Critical Hit.

Sentry: +200 Critical Rate and Critical Damage Rate for each Reality Warp.
Unique Synergy: Does not stack with duplicate synergies.
Mister Negative
Spider-Man (Classic)
Spider Man (Stark Enhanced)
Spider-Man (Stealth-Suit)
FROM LIGHT TO DARK
#Spider-Verse Heroes: Start the fight with 2 indefinite Passive Dark Energy. When using any Special Attack, 1 Dark Energy is consumed to inflict a 15 second Debuff determined by the last basic attack landed.
Heavy Attack: Weakness, reducing attack rating by 30%.
Light Attack: Armor Break, reducing Armor Rating by 300.
Medium Attack: Degen, dealing 90% of Modified Attack.
Morningstar
The Overseer
Spider-Man (Supreme)
Venom The Duck
Venompool
FROM THE CONTEST
Morningstar: Special 2 Attacks deal an extra, half-potency Burst of Energy Damage per Captured Soul.

The Overseer: Gain immunity to Neutralize

Spider-Man (Supreme): Critical Hits from Light or Heavy Attacks grant a Spider-Seal Buff to the Opponent.

Venom The Duck: When a Symbiote Buff is consumed, 25% chance to re-trigger it.

Venompool: Gain Special Lock immunity, and this immunity counts for his Illogical DNA ability.
Unique Synergy: Does not stack with duplicate synergies.
Mangog
Odin
FUELED WITH RAGE
Mangog: Become immune to Nullify. Each time Nullify is prevented, gain a non-stacking Precision Buff, granting +350 Critical Rating for 15 seconds.

Odin: When dealing a burst of Direct Damage using a Special 2 Attack, the damage threshold of each burst is increased by 150% of Odin’s Base Attack Rating.
Unique Synergy: Does not stack with duplicate synergies.
Diablo
Dragon Man
FULL METAL
Diablo: Philosopher’s Mix gains +20% duration. Additionally, Vials of Might grant +10% Special Damage.

Dragon Man: Dragon Man’s Special 3 generates an additional stack of Power Charge.
Unique Synergy: Does not stack with duplicate Synergies.
Iron Fist
Nova
Rhino
FULL SPEED AHEAD
Iron Fist: Medium Attacks gain +5% chance for each Armor Break Debuff on the Opponent to inflict a Stun Debuff for 1.5 seconds.

Nova: Starting a Dash Attack immediately after Dashing Back generates 5 additional Nova Charges.

Rhino: 30% Chance to refresh Fury Buffs when striking with Medium Attacks.
Unique Synergy: Does not stack with duplicate synergies.
Kraven
Squirrel Girl
FUN ADVENTURES
Kraven: Bleed Immune Champions are inflicted by a Poison Debuff instead, reducing Health Recovery by 30% and Dealing 17% of Attack in Direct Damage over 10 second(s). Poison pauses and refreshes just as Bleed.

Squirrel Girl: When the Opponent is afflicted by an Injury Debuff, Squirrel Girl has 50% chance to gain a Precision Buff, increasing Critical Rating by [1500, 1710], and 50% chance to gain a Cruelty Buff, increasing Critical Damage Rating by [700, 798], both effects lasts for 10 second(s).
Unique Synergy: Does not stack with duplicate synergies.
Sasquatch
Squirrel Girl
FURRY BUDS
Sasquatch: Rupture effects last 20% longer.

Squirrel Girl: When Tippy-Toe attaches to the Opponent she stays on for 30% longer.
Unique Synergy: Does not stack with duplicate synergies.
Hit-Monkey
Rocket Raccoon
Squirrel Girl
Beast
FURRY FRENEMIES
Hit-Monkey: Critical Hits have a 30% chance to Armor Break the Opponent for 6 second(s), reducing their Armor Rating by 700.

Rocket Raccoon: Critical Hits grant Rocket 1 additional Scrap Metal.

Squirrel Girl: Activate Combo Shield for 5 second(s) when this Champion would lose their Combo Meter from being struck. This activates only once per fight.

Beast: Activate Combo Shield for 5 second(s) when this Champion would lose their Combo Meter from being struck. This activates only once per fight.
Unique Synergy: Does not stack with duplicate synergies.
Beta Ray Bill
Moondragon
Groot
Captain Marvel
Galactic Breakout
Beta Ray Bill: The final hit of a Special Attack Pulverizes 3 Armor Ups, each dealing 100% of Attack as Direct Damage.

Moondragon: Psionic Transcendence is not active, Mind Blasts trigger 2 times when punishing the Opponent’s Special Attacks.

Groot: Fury and Cruelty Buffs gain 25% duration.

Captain Marvel: Basic Attacks have a 15% chance to grant 1 Persistent Energy Charge.
Unique Synergy: Does not stack with duplicate synergies.
Adam Warlock
Silver Surfer
GALACTIC DISRUPTION
Synergy Members: When the champion gains 4+ Buffs, gain an Aptitude Buff, increasing the potency of Precision, Fury and Armor Up Buffs by 25% for 15 seconds. Cooldown: 15 seconds.
Unique Synergy: Does not stack with duplicate synergies.
Sorcerer Supreme
Hulk
Hulk (Ragnarok)
Joe Fixit
Red Hulk
She-Hulk
GAMMA HORDE
Sorcerer Supreme: Stun Debuffs inflicted on the Opponent last 25% longer.

Hulk: Stun Debuffs inflicted on the Opponent last 25% longer.

Hulk (Ragnarok): Stun Debuffs inflicted on the Opponent last 25% longer.

Joe Fixit: Stun Debuffs inflicted on the Opponent last 25% longer.

Red Hulk: Stun Debuffs inflicted on the Opponent last 25% longer.

She-Hulk: Stun Debuffs inflicted on the Opponent last 25% longer.
Unique Synergy: Does not stack with duplicate synergies.
Hulk (Immortal)
Abomination (Immortal)
Sasquatch
She-Hulk
GAMMA MUTATES
Hulk (Immortal): +5% Max Health.

Abomination (Immortal): +5% Max Health.

Sasquatch: +5% Max Health.

She-Hulk: +5% Max Health.
Unique Synergy: Does not stack with duplicate synergies.
Hulk
Sasquatch
GAMMA RAY RAY
Hulk: Stunned Opponents suffer -100% Ability Power Rate. This effect lingers for 0.2 seconds after the Stun expires.

Sasquatch: Special 2 inflicts 1 additional Rupture Debuff.
Unique Synergy: Does not stack with duplicate synergies.
Beast
Nightcrawler
Archangel
Professor X
GATEWAY
Beast: Increase the duration of Freestyle and Acrobatic Combo Success by 5 second(s).

Nightcrawler: +30% Bleed Potency.

Archangel: +30% Bleed Potency.
All Mutants and X-Men except Professor X: Gain 6% of a bar of Power every 10 second(s) for each Cerebro Charge. Max 24%.
Unique Synergy: Does not stack with duplicate synergies.
Cable
Mister Sinister
GENETIC MASTERPIECE
All Mutants: Randomly start the fight with either +25% passive Attack Rating, +25% passive Power Rate, or +25% passive Armor Rating.
Unique Synergy: Does not stack with duplicate synergies.
Venom The Duck
Venompool
Carnage
GENETIC RECODE - AGGRESSION
+25% chance to activate Frenzy Symbiote Buffs.
Solo: Only affects this Champion and does not stack.